← Back to Search

Behavioural Intervention

Cognitive Fitness for Depression

N/A
Recruiting
Led By Kevin Manning, Ph.D.
Research Sponsored by UConn Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Current major or mild depression despite ongoing treatment
current major or mild depression despite ongoing treatment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-treatment and six weeks later when treatment has ended
Awards & highlights

Study Summary

This trial is testing if computerized activities can improve thinking and depression in older adults with antidepressants, and if there are changes to brain activity.

Who is the study for?
This trial is for older adults who are experiencing depression and cognitive issues despite being treated with antidepressants. Participants must be able to read and write in English, have been on antidepressants for at least 8 weeks, and be under a doctor's care. People with psychosis, other major psychiatric disorders besides personality or generalized anxiety disorders, recent substance use disorders, dementia, significant neurological conditions or severe vision problems cannot join.Check my eligibility
What is being tested?
The study is testing whether computerized cognitive exercises can improve thinking abilities and reduce symptoms of depression in older adults already taking antidepressants. It also aims to see if these activities change brain activity as seen on MRI scans.See study design
What are the potential side effects?
Since the intervention involves non-invasive computer activities designed to enhance cognitive function, there are no direct physical side effects expected from the treatment itself. However, participants may experience fatigue or frustration.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am currently experiencing depression despite treatment.
Select...
I am currently experiencing depression despite treatment.
Select...
I have been taking an antidepressant for at least 8 weeks.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-treatment and six weeks later when treatment has ended
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-treatment and six weeks later when treatment has ended for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in attention / cognitive flexibility as measured by the Trail Making Part B test
Change in depression symptom severity as measured with the Montgomery Asberg Depression Rating Scale (MADRS)
Secondary outcome measures
Change in attention processing speed as measured with the Flanker Test of Response Inhibition from the NIH Cognitive Toolbox
Change in problem solving/speed/spatial memory as measured with the NIH Toolbox fluid composite scales
Change in self-reported depressive symptoms measured with the Carroll Depression Rating Scale
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Computerized Cognitive Remediation of Executive Functioning (CCR-EF)Experimental Treatment1 Intervention
Initially 10 hours of processing speed exercises from "Brain HQ", (the 3 exercises are auditory tone sweep, visual processing [Double Decision], visual sweep). Following the 8-10 hours of Brain HQ, participants complete 8-10 hours of "Ultimate Word Master" before completing 16-20 hours of "Neurogrow" (formerly called "Catch the Ball"). Participants are asked to complete approximately 28-42 hours of computerized brain training over 4-6 weeks.
Group II: Active ControlActive Control1 Intervention
Patients in the active control arm will complete three activities according to a standard protocol: 1) play a visuospatially oriented computer game (Myst), 2) watch computer-based educational programs on art, history, literature, and 3) play computer games online through the Brain HQ platform; games include crossword puzzles, soduko, paddleboard, and word search. Participants will complete a total of 32-42 hours of training over 4-6 weeks. Time spent on each task will be evenly divided (15 minutes of each task everday).

Find a Location

Who is running the clinical trial?

UConn HealthLead Sponsor
211 Previous Clinical Trials
60,483 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,561 Total Patients Enrolled
Kevin Manning, Ph.D.Principal Investigator - UConn Health
UConn Health

Media Library

Computerized Cognitive Remediation of Executive Functioning (CCR-EF) (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04790630 — N/A
Major Depressive Disorder Research Study Groups: Active Control, Computerized Cognitive Remediation of Executive Functioning (CCR-EF)
Major Depressive Disorder Clinical Trial 2023: Computerized Cognitive Remediation of Executive Functioning (CCR-EF) Highlights & Side Effects. Trial Name: NCT04790630 — N/A
Computerized Cognitive Remediation of Executive Functioning (CCR-EF) (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04790630 — N/A
Major Depressive Disorder Patient Testimony for trial: Trial Name: NCT04790630 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacant slots in this research project?

"Affirmative. According to the data available on clinicaltrials.gov, this trial is actively engaging in patient enrolment. This study was initially published on November 15th 2020 and has been edited as recently as November 2nd 2022; 138 participants must be found at a single location."

Answered by AI

What is the upper limit of participation in this experiment?

"Affirmative. The information on clinicaltrials.gov confirms that this study is presently seeking volunteers; it was initially posted in November 2020 and the last update occurred in November 2022. This trial requires 138 participants to be enrolled at a single medical centre."

Answered by AI

What is the end goal of this medical trial?

"The primary goal of this trial, which will be assessed prior to treatment and six weeks after the end of it, is a shift in depression symptom severity as evaluated through the Montgomery Asberg Depression Rating Scale (MADRS). Secondary targets include changes in self-reported symptoms utilizing the Carroll Depression Rating Scale; cognitive functioning measured by NIH Toolbox fluid composite scales; and verbal learning capacity determined with California Verbal Learning Test (CVLT) Total Learning - number of words recalled over 5 trials plus spontaneous semantic organization."

Answered by AI

Who else is applying?

What state do they live in?
Connecticut
What site did they apply to?
UConn Health
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I was waiting to get into s clinical trial forMCI and this popped up on my phonr along with other trials , i opted for this one .
PatientReceived 1 prior treatment

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. UConn Health: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Cognitive Fitness for Depression in Older Adults
Kevin Manning 2020. "Cognitive Fitness for Depression in Older Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04790630.
All > Mdd
~9 spots leftby Jul 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top