Cognitive Fitness for Depression
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether computer-based brain exercises can improve thinking and reduce depression in older adults already on antidepressants. Participants will either engage in specific brain games designed to boost mental skills, known as Computerized Cognitive Remediation of Executive Functioning (CCR-EF), or participate in a series of educational and recreational computer activities. Researchers aim to determine if these activities alter brain activity, which will be assessed using an MRI (a type of brain scan). This trial may suit individuals who have experienced depression despite taking medication for at least eight weeks. As an unphased trial, it offers a unique opportunity to contribute to understanding innovative non-drug therapies for depression.
Do I need to stop my current medications for the trial?
No, you do not need to stop your current medications. The trial is for people who are already being treated with antidepressants.
What prior data suggests that computerized cognitive fitness activities are safe for older adults with depression?
Research has shown that computerized brain training, such as the Computerized Cognitive Remediation of Executive Functioning (CCR-EF) used in this trial, is generally easy for participants to handle. In past studies, 91% of participants completed similar programs without major problems, indicating that most people manage the treatment well.
CCR-EF focuses on brain exercises that are non-invasive, meaning they don't involve surgery or medication. This significantly lowers the risk of serious side effects compared to treatments with drugs or medical procedures. Related research has reported no significant negative effects.
Overall, evidence suggests that CCR-EF is a safe option for improving brain function and reducing symptoms of depression.12345Why are researchers excited about this trial?
Researchers are excited about the Cognitive Fitness for Depression trial because it explores a novel approach to enhancing mental health through brain training exercises. Unlike traditional methods such as medication and talk therapy, this approach uses computerized cognitive remediation to specifically target and improve executive functioning. The CCR-EF method is unique because it combines various brain training exercises that focus on processing speed and cognitive flexibility, offering a structured yet engaging way for participants to potentially enhance their mental acuity. This non-invasive and interactive approach could offer an alternative or supplement to existing treatments, making it an exciting frontier in the fight against depression.
What evidence suggests that computerized cognitive remediation of executive functioning is effective for improving thinking and depression in older adults?
Research has shown that computer-based brain exercises can improve focus and decision-making skills. In this trial, participants will join different treatment arms to assess the effectiveness of these exercises. One arm will involve Computerized Cognitive Remediation of Executive Functioning (CCR-EF), which has been linked to better memory, focus, and mood in people with depression. Another arm will serve as an active control, where participants engage in various computer-based activities like games and educational programs. Studies have found that this type of therapy often enhances attention and mood. A review of several studies found that computerized cognitive training (CCT) was connected to fewer depression symptoms and better daily functioning. Overall, these findings suggest that computer-based activities might improve thinking and mood in older adults with depression.56789
Who Is on the Research Team?
Kevin Manning, Ph.D.
Principal Investigator
UConn Health
Are You a Good Fit for This Trial?
This trial is for older adults who are experiencing depression and cognitive issues despite being treated with antidepressants. Participants must be able to read and write in English, have been on antidepressants for at least 8 weeks, and be under a doctor's care. People with psychosis, other major psychiatric disorders besides personality or generalized anxiety disorders, recent substance use disorders, dementia, significant neurological conditions or severe vision problems cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in computerized cognitive fitness activities to improve thinking and depression over 4-6 weeks
Follow-up
Participants are monitored for changes in cognitive function and depression symptoms after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF)
Find a Clinic Near You
Who Is Running the Clinical Trial?
UConn Health
Lead Sponsor
National Institute of Mental Health (NIMH)
Collaborator