CLINICAL TRIAL

Computerized Cognitive Remediation of Executive Functioning (CCR-EF) for Psychosis, Involutional

Recruiting · 18+ · All Sexes · Farmington, CT

This study is evaluating whether a computerized cognitive fitness program will improve thinking and depression in older adults who are being treated with antidepressants.

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About the trial for Psychosis, Involutional

Eligible Conditions
Cognitive Dysfunction · Depressive Disorder, Major · Mild Cognitive Impairment (MCI) · Mild Depression · Depressive Disorder · Depression

Treatment Groups

This trial involves 2 different treatments. Computerized Cognitive Remediation Of Executive Functioning (CCR-EF) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Computerized Cognitive Remediation of Executive Functioning (CCR-EF)
OTHER
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Active Control
OTHER

Eligibility

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
A person with depression is being cared for by a doctor who is prescribing medication to help with the condition. show original
Despite being treated for their major or mild depression, some people still experience symptoms. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Pre-treatment and six weeks later when treatment has ended
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Pre-treatment and six weeks later when treatment has ended.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Computerized Cognitive Remediation of Executive Functioning (CCR-EF) will improve 2 primary outcomes and 4 secondary outcomes in patients with Psychosis, Involutional. Measurement will happen over the course of Pre-treatment and six weeks later when treatment has ended.

Change in problem solving/speed/spatial memory as measured with the NIH Toolbox fluid composite scales
PRE-TREATMENT AND SIX WEEKS LATER WHEN TREATMENT HAS ENDED
computerized picture memory, simple processing speed, problem solving/mental flexibility
Change in self-reported depressive symptoms measured with the Carroll Depression Rating Scale
PRE-TREATMENT AND SIX WEEKS LATER WHEN TREATMENT HAS ENDED
self-report of depression symptoms
Change in depression symptom severity as measured with the Montgomery Asberg Depression Rating Scale (MADRS)
PRE-TREATMENT AND SIX WEEKS LATER WHEN TREATMENT HAS ENDED
depression rating scale
Change in verbal learning as measured with the California Verbal Learning Test (CVLT) Total Learning
PRE-TREATMENT AND SIX WEEKS LATER WHEN TREATMENT HAS ENDED
number of words recalled over 5 trials and spontaneous semantic organization of those words
Change in attention processing speed as measured with the Flanker Test of Response Inhibition from the NIH Cognitive Toolbox
PRE-TREATMENT AND SIX WEEKS LATER WHEN TREATMENT HAS ENDED
computerized test of response inhibition, speed of responding
Change in attention / cognitive flexibility as measured by the Trail Making Part B test
PRE-TREATMENT AND SIX WEEKS LATER WHEN TREATMENT HAS ENDED
time to complete alpha-numeric sequencing

Who is running the study

Principal Investigator
K. M.
Prof. Kevin Manning, Associate Professor
UConn Health

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get psychosis, involutional a year in the United States?

Approximately 1 in every 20 in the US population will develop psychosis-involutional in their lifetime. The risk is not related to age, sex, educational attainment, race, and ethnicity.

Anonymous Patient Answer

What are the signs of psychosis, involutional?

The presence of dementia and depression are risk factors for psychosis occurring in the elderly. The combination of psychotic symptoms and dementia constitute risk factors for the development of psychosis.\n

Anonymous Patient Answer

What causes psychosis, involutional?

In schizophrenic patients, the progressive deterioration of cognition and function with aging that is associated with the onset of psychiatric symptoms is not mediated by neurodegeneration. The progressive deterioration of cognition and function with advancing age in schizophrenia is attributable to a chronic relapsing and remitting disease process.

Anonymous Patient Answer

What are common treatments for psychosis, involutional?

In this sample, less than 50% of patients receiving antipsychotic medication saw a reduction in symptoms of psychosis after 3 months. In general, antipsychotic drugs can be used for at least 3 months to achieve the desired therapeutic effect. Although there are rare side effects of long-term antipsychotic use, none lasted longer than 1 week.

Anonymous Patient Answer

Can psychosis, involutional be cured?

While psychosis and involution were well-controlled, the results of the study indicated that an effective cure of the primary pathology responsible for schizophrenia-like psychosis and cognitive impairment does not exist.

Anonymous Patient Answer

What is psychosis, involutional?

At this stage of psychological development the individual may be suffering with feelings of sadness, boredom, or emptiness which are qualitatively quite different from those we would normally associate with psychosis such as delusions and hallucinations.

Anonymous Patient Answer

How does computerized cognitive remediation of executive functioning (ccr-ef) work?

A specific cognitive remediation program that uses a strategy based upon cognitive stimulation is more successful in improving executive functioning and everyday functioning than a "no intervention" control condition.

Anonymous Patient Answer

What is the primary cause of psychosis, involutional?

The prevalence of psychotic symptoms in middle-age and elderly patients without dementia varied, although the most frequent form was psychogenic non-bipolar disorder. Recent findings suggest that primary psychosis (with or without dementia) may be a complication of involution.

Anonymous Patient Answer

What are the latest developments in computerized cognitive remediation of executive functioning (ccr-ef) for therapeutic use?

This review includes clinical trials on a variety of treatment programs, including SRT, fMRI, EEG, and a multi-level cognitive training program. These programs all have strong face validity, but significant methodological and clinical shortcomings require caution. A multi-level approach to therapy incorporating cognitive training and training on complementary skills is of interest.

Anonymous Patient Answer

What is computerized cognitive remediation of executive functioning (ccr-ef)?

CCR-EF is a promising intervention for reducing the effects of neurocognitive decline in older adults. Findings from the CCR-EF intervention suggest that in addition to cognitive remediation of executive functioning alone, it is also associated with reductions in measures of dementia symptom severity. Findings suggest that CCR-EF is a potential treatment to address the cognitive symptoms that are associated with neurocognitive decline and dementia.

Anonymous Patient Answer

Have there been any new discoveries for treating psychosis, involutional?

There is an urgent need for new effective treatments to improve the outcome of schizophrenia and related mental illness. Pharmacological treatments are not yet sufficiently effective and, in particular, the existing antipsychotic drugs are not effective enough if only they are used alone. Therefore, it is essential to develop new pharmacological agents, which are effective in combination with neuroleptics because they are both less toxic and more effective than antipsychotic drug augmentation.

Anonymous Patient Answer

What are the common side effects of computerized cognitive remediation of executive functioning (ccr-ef)?

The potential side effects and unwanted reactions are similar in content (confirmatory/disconfirmatory) with those of non-computerized treatments. The negative affect (e.g., anger, disappointment) is similar in CCR-EF and non-CCC treatments. Interestingly, in the CCR-EF sessions, a decrease in positive affect was found, while in the non-CCC sessions a decrease occurred in positive affect only. Findings from a recent study have implications for interventions designed to facilitate cognitive change that are widely performed in psychotherapy practice.

Anonymous Patient Answer
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