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1 Hz left prefrontal rTMS for Depression

N/A
Waitlist Available
Led By Paul E Croarkin, DO
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Study Summary

This trial will test if transcranial magnetic stimulation (TMS) can help treat adolescent depression. Researchers will also use TMS to see if brain activity can be used to predict which patients will respond best to certain types of TMS treatment.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total Children's Depression Rating Scale, Revised (CDRS-R) Score
Secondary outcome measures
Change in Intracortical Facilitation (ICF)

Trial Design

2Treatment groups
Active Control
Group I: 1 Hz left prefrontal rTMSActive Control2 Interventions
36 sessions of 1 Hz rTMS at 120% motor threshold applied to the left prefrontal cortex. Each session is 2400 continuous pulses.
Group II: 10 Hz left prefrontal rTMSActive Control2 Interventions
36 sessions of 10 Hz rTMS at 120% motor threshold applied to the left prefrontal cortex. Each session is 2400 pulses with 4 seconds on and 36 seconds off.

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,209 Previous Clinical Trials
3,767,087 Total Patients Enrolled
40 Trials studying Depression
3,555 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,785 Previous Clinical Trials
2,689,709 Total Patients Enrolled
667 Trials studying Depression
251,584 Patients Enrolled for Depression
NeuroneticsOTHER
22 Previous Clinical Trials
7,505 Total Patients Enrolled
13 Trials studying Depression
7,127 Patients Enrolled for Depression

Frequently Asked Questions

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Recent research and studies
Journal of Child and Adolescent PsychopharmacologyJournal
Magnetic Resonance Imaging-guided, Open-label, High-frequency Repetitive Transcranial Magnetic Stimulation for Adolescents with Major Depressive Disorder
Wall, Christopher A., Paul E. Croarkin, Mandie J. Maroney-Smith, Laura M. Haugen, Joshua M. Baruth, Mark A. Frye, Shirlene M. Sampson, and John D. Port. 2016. “Magnetic Resonance Imaging-guided, Open-label, High-frequency Repetitive Transcranial Magnetic Stimulation for Adolescents with Major Depressive Disorder”. Journal of Child and Adolescent Psychopharmacology. Mary Ann Liebert Inc. doi:10.1089/cap.2015.0217.
Brain StimulationJournal
Safety of Noninvasive Brain Stimulation in Children and Adolescents
Krishnan, Chandramouli, Luciana Santos, Mark D. Peterson, and Margaret Ehinger. 2015. “Safety of Noninvasive Brain Stimulation in Children and Adolescents”. Brain Stimulation. Elsevier BV. doi:10.1016/j.brs.2014.10.012.
Brain StimulationJournal
Addressing the Needs of Adolescents with Treatment Resistant Depressive Disorders: A Systematic Review of Rtms
Donaldson, Amy E., Michael S. Gordon, Glenn A. Melvin, David A. Barton, and Paul B. Fitzgerald. 2014. “Addressing the Needs of Adolescents with Treatment Resistant Depressive Disorders: A Systematic Review of Rtms”. Brain Stimulation. Elsevier BV. doi:10.1016/j.brs.2013.09.012.
JAMA PsychiatryJournal
Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents with Major Depressive Disorder
Croarkin, Paul E., Paul A. Nakonezny, Mustafa M. Husain, Tabatha Melton, Jeylan S. Buyukdura, Betsy D. Kennard, Graham J. Emslie, F. Andrew Kozel, and Zafiris J. Daskalakis. 2013. “Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents with Major Depressive Disorder”. JAMA Psychiatry. American Medical Association (AMA). doi:10.1001/2013.jamapsychiatry.24.
~7 spots leftby Apr 2025
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