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Transcranial Magnetic Stimulation

Active TBS-DLPFC for Depression

N/A
Waitlist Available
Led By Rajamannar Ramasubbu, MD,FRCPC,MSc
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline at 5 days of tbs treatment
Awards & highlights

Study Summary

This study investigates the brain-based biomarkers of treatment response to accelerated theta burst stimulation (aTBS) in patients with Major Depressive Disorder resistant to pharmacological treatment(MDD) in an open label design.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline at 5 days of tbs treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline at 5 days of tbs treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hamilton Depression Rating Scale
Secondary outcome measures
1. Montgomery-Åsberg Depression Rating Scale (MADRS)
2. Columbia Suicide Severity Rating Scale ( CSSRS)
2. Hamilton Anxiety rating Scale (HAM-A)
+7 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Active TBS-DLPFCExperimental Treatment1 Intervention
There is only one arm. All participants will receive Theta Burst Stimulation (transcranial magnetic stimulation) of the dorsolateral prefrontal cortex.

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
792 Previous Clinical Trials
869,124 Total Patients Enrolled
31 Trials studying Depression
10,610 Patients Enrolled for Depression
Rajamannar Ramasubbu, MD,FRCPC,MScPrincipal InvestigatorUniversity of Calgary, Department of Psychiatry

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Alberta
How old are they?
65+
What site did they apply to?
University of Calgary
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
BrainJournal
Efficacy of Prefrontal Theta-burst Stimulation in Refractory Depression: A Randomized Sham-controlled Study
Li, Cheng-Ta, Mu-Hong Chen, Chi-Hung Juan, Hsiang-Hsuan Huang, Li-Fen Chen, Jen-Chuen Hsieh, Pei-Chi Tu, et al.. 2014. “Efficacy of Prefrontal Theta-burst Stimulation in Refractory Depression: A Randomized Sham-controlled Study”. Brain. Oxford University Press (OUP). doi:10.1093/brain/awu109.
Journal of Clinical NeurophysiologyJournal
Safety of Theta Burst Transcranial Magnetic Stimulation: A Systematic Review of the Literature
Oberman, Lindsay, Dylan Edwards, Mark Eldaief, and Alvaro Pascual-Leone. 2011. “Safety of Theta Burst Transcranial Magnetic Stimulation: A Systematic Review of the Literature”. Journal of Clinical Neurophysiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/wnp.0b013e318205135f.
Journal of Affective DisordersJournal
Accelerated Intermittent Theta Burst Stimulation Treatment in Medication-resistant Major Depression: A Fast Road to Remission?
Duprat, Romain, Stefanie Desmyter, De Raedt Rudi, Kees van Heeringen, Dirk Van den Abbeele, Hannelore Tandt, Jasmina Bakic, et al.. 2016. “Accelerated Intermittent Theta Burst Stimulation Treatment in Medication-resistant Major Depression: A Fast Road to Remission?”. Journal of Affective Disorders. Elsevier BV. doi:10.1016/j.jad.2016.04.015.
Depression and AnxietyJournal
Theta-burst Stimulation: A New Form of Tms Treatment for Depression?
Chung, Sung Wook, Kate E. Hoy, and Paul B. Fitzgerald. 2014. “Theta-burst Stimulation: A New Form of Tms Treatment for Depression?”. Depression and Anxiety. Wiley. doi:10.1002/da.22335.
All > Mdd
~4 spots leftby Apr 2025
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