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UPLIFT for Depression

N/A
Waitlist Available
Led By Michael S Schechter, MD, MPH
Research Sponsored by Virginia Commonwealth University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (at 0 week), tx end (at 8 weeks), follow-up (at 6 months post tx end), extended follow-up (at 12 months post tx end)
Awards & highlights

Study Summary

This trial will test the effectiveness of an online mental health intervention, Project UPLIFT, in reducing anxiety and depression in people with CF.

Eligible Conditions
  • Depression
  • Anxiety
  • Cystic Fibrosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (at 0 week), tx end (at 8 weeks), follow-up (at 6 months post tx end), extended follow-up (at 12 months post tx end)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (at 0 week), tx end (at 8 weeks), follow-up (at 6 months post tx end), extended follow-up (at 12 months post tx end) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reduce symptoms of anxiety among UPLIFT Tx Group participants.
Reduce symptoms of depression among UPLIFT Tx Group participants.
Secondary outcome measures
Improve knowledge and skills regarding self-management of anxiety and depression among UPLIFT Tx Group participants.
Increase quality of life among UPLIFT Tx Group participants.
Increase satisfaction with life among UPLIFT Tx Group participants.
+1 more
Other outcome measures
(Exploratory) Change in CF disease severity status.

Trial Design

2Treatment groups
Experimental Treatment
Group I: UPLIFTExperimental Treatment1 Intervention
The Project UPLIFT intervention was designed for delivery to groups of six to eight people by telephone or Internet, though for this study the intervention will be web based only. The telephone intervention comprised eight hour-long sessions, each including check-in, instruction, skill building, and discussion, with homework between sessions. The Web intervention contains the same elements: check-in, video instruction, skill building, a discussion board, and homework between sessions. Instruction focuses on increasing knowledge about depression, cystic fibrosis (CF), cognitive behavioral therapy (CBT), and mindfulness and skills related to CBT and mindfulness.
Group II: Control GroupExperimental Treatment1 Intervention
Treatment-as-usual
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
UPLIFT
2017
N/A
~170
Treatment as usual
2010
N/A
~6760

Find a Location

Who is running the clinical trial?

Cystic Fibrosis FoundationOTHER
189 Previous Clinical Trials
37,125 Total Patients Enrolled
1 Trials studying Depression
60 Patients Enrolled for Depression
University of MichiganOTHER
1,797 Previous Clinical Trials
6,377,973 Total Patients Enrolled
67 Trials studying Depression
69,038 Patients Enrolled for Depression
Boston Children's HospitalOTHER
761 Previous Clinical Trials
5,579,645 Total Patients Enrolled
7 Trials studying Depression
1,469 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Project UPLIFT to Reduce Anxiety and Depression in CF Patients
2015. "Project UPLIFT to Reduce Anxiety and Depression in CF Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03139266.
~8 spots leftby Apr 2025
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