Message-based psychotherapy (MBP) for Melancholia
This study is evaluating whether unlimited text-based psychotherapy for depression is as effective as once-a-week psychotherapy.
See full descriptionAbout the trial for Melancholia
Treatment Groups
This trial involves 10 different treatments. Message-based Psychotherapy (MBP) is the primary treatment being studied. Participants will be divided into 10 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Message-based psychotherapy (MBP) will improve 3 primary outcomes, 1 secondary outcome, and 5 other outcomes in patients with Melancholia. Measurement will happen over the course of Change from Baseline PHQ-9 at 6 weeks and 12 weeks after treatment starts.
Who is running the study
Principal InvestigatorPatient Q & A Section
Can melancholia be cured?
Melancholia has no curative treatment; people with severe depression can die. The term 'cure' is inoffensive; it implies a medical notion of 'fixing the illness'. People do not have the 'cure' they deserve.
What are common treatments for melancholia?
Antidepressants can produce significant mood elevations. Some antidepressants also produce euphoria and psychosis. Selective serotonin reuptake inhibitors can be useful in mild depression and panic disorder. Electroconvulsive therapy (ECT) is effective in the short-term treatment of bipolar depression and treatment-resistant depression. In severe depression or psychosis, the benefits of ECT may be outweighed by adverse effects. In other severe illnesses, ECT is ineffective. Antipsychotics are used in schizophrenia for both psychotic episodes and depressive episodes. Atypical antipsychotics are preferred over classical antipsychotics because of fewer extrapyramidal side effects as well as a lower risk of cardiovascular disease and metabolic syndrome.
What is melancholia?
While no specific criteria have been established, the term'melancholia' is often used in this manner. Although the depressive phase of the depressive episode can be severe, for many individuals there are several depressive phases, sometimes with periods of elation in between. In this article, a more precise definition of what'melancholia' is is provided, and how patients might be best served by psychiatric treatments, or a combination of both. It is also discussed how our understanding of depression has evolved over recent decades.
What are the signs of melancholia?
Signs of melancholia are more akin to those of depression. The melancholic state has feelings of sadness and despairing mood. Subjective symptoms of melancholy could include suicidal thoughts along with increased anxiety or irritability. Although they appear similar, they are not the same.\n
How many people get melancholia a year in the United States?
Up to 75 million US adults may be suffering from a depressive episode a year. This is a substantial problem as about 10% of all US adult inpatient admissions are related to depression.
What causes melancholia?
Current beliefs about melancholia may be biased by the social expectations of psychiatrists. As with many common psychiatric diagnoses, there is a shortage of research on the causes and symptomatology of melancholia.
Is message-based psychotherapy (mbp) safe for people?
This is the first prospective randomized controlled trial that has found Mbt to be safe. This trial, along with an expanding body of evidence, suggests that MBT can be a helpful complementary intervention.
What is the latest research for melancholia?
The recent literature is rich with research studies regarding the neurochemistry of melancholic patients. Although there are several factors that may influence the onset of melancholia, there are still some unanswered questions. It will be extremely important to clarify why only some patients feel overwhelmed by the stress of certain events or circumstances, while others feel no stress and are more resilient. Scientists need to work tirelessly to discover the precise neuro-chemical makeup in the brains of melancholic patients.
Does melancholia run in families?
Based on the results of our study we conclude that familial occurrence of melancholic features is not restricted to bipolar depression, but can also be an isolated trait.
What are the latest developments in message-based psychotherapy (mbp) for therapeutic use?
mbp is being developed for a variety of clinical, psychosocial, organizational, and individual purposes. The focus of mbp is to improve outcomes in both the individual and organizational domains. Mbn’s unique structure has the potential to improve outcomes for all users.
What does message-based psychotherapy (mbp) usually treat?
MBP is based on a cognitive, existential, interpersonal, and psychological account of the illness and it is suggested as a first line treatment for depressive disorders.
How serious can melancholia be?
Patients with melancholia can present with significant distress and impairment, even in a mild sub-clinical form. Therefore, depression and anxiety are serious medical conditions that deserve attention on both sides of the equator. However, some studies and the Brazilian guidelines on depression recommend that the diagnosis of a depressive disorders to always include a melancholic syndrome. In addition, treatment algorithms based on melancholia were defined in clinical guidelines, but they recommend the use of depression treatment based on the most current recommendations. More research is needed in order to define the optimal treatment for these patients.