Study Summary
This trial is testing whether two different interventions for depression, Behavioral Activation (BA) and Problem Solving Therapy (PST), are more or less effective depending on a person's exposure to adverse childhood experiences.
Eligible Conditions
- Adverse Childhood Experiences
- Teen Depression
Treatment Effectiveness
Effectiveness Progress
Study Objectives
7 Primary · 2 Secondary · Reporting Duration: Pre-intervention vs. 1-month post-intervention
Immediately post-intervention
Executive functioning (planning initial thinking time)
Executive functioning (planning moves)
Executive functioning (planning total)
Executive functioning (task-switching congruent errors)
Executive functioning (task-switching incongruent errors)
Executive functioning (task-switching reaction latency)
Executive functioning (task-switching total incorrect)
Reward responsiveness immediately post-intervention
Reward sensitivity immediately post-intervention
Pre-intervention vs. 1-month post-intervention
Change in clinician-rated depression symptoms from baseline to one-month follow-up
Change in self-reported depression symptoms from baseline to one-month follow-up
immediately post-intervention; baseline vs. 1-month follow-up
Problem Resolution Outcome Survey (PROS) up to 1-month follow-up
immediately post-intervention; baseline vs. 1-month post-intervention
Behavioral Activation for Depression Scale (BADS) up to 1-month follow-up
Reward Probability Index (RPI) up to 1-month follow-up
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Problem Solving Therapy (PST)
1 of 2
Behavioral Activation (BA) Therapy
1 of 2
Active Control
Experimental Treatment
40 Total Participants · 2 Treatment Groups
Primary Treatment: Behavioral Activation (BA) Therapy · No Placebo Group · N/A
Behavioral Activation (BA) Therapy
Behavioral
Experimental Group · 1 Intervention: Behavioral Activation (BA) Therapy · Intervention Types: BehavioralProblem Solving Therapy (PST)
Behavioral
ActiveComparator Group · 1 Intervention: Problem Solving Therapy (PST) · Intervention Types: BehavioralTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: pre-intervention vs. 1-month post-intervention
Who is running the clinical trial?
University of PittsburghLead Sponsor
1,617 Previous Clinical Trials
16,298,455 Total Patients Enrolled
The Klingenstein Third Generation FoundationOTHER
4 Previous Clinical Trials
1,311 Total Patients Enrolled
Rachel A Vaughn-Coaxum, Ph.D.Principal InvestigatorUniversity of Pittsburgh
1 Previous Clinical Trials
90 Total Patients Enrolled
Eligibility Criteria
Age 12 - 15 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You have elevated depressive symptoms.
References
- Pass, Laura, Carl W. Lejuez, and Shirley Reynolds. 2017. “Brief Behavioural Activation (brief BA) for Adolescent Depression: A Pilot Study”. Behavioural and Cognitive Psychotherapy. Cambridge University Press (CUP). doi:10.1017/s1352465817000443.
- Eskin M, Ertekin K, Demir H. Efficacy of a problem-solving therapy for depression and suicide potential in adolescents and young adults. Cognit Ther Res. 2008;32(2):227-245. doi:10.1007/s10608-007-9172-8
- Rachel Vaughn-Coaxum 2021. "Shaping Actions and Responses to Emotions". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04719949.
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Conditions
Cancer Related
Treatments