Interpersonal Therapy for Depression

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Illinois, Urbana, IL
Depression+1 More
Interpersonal Therapy - Behavioral
Eligibility
18+
Female
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Study Summary

This study is evaluating whether a type of psychotherapy called interpersonal therapy may help treat depression in pregnant women.

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Eligible Conditions

  • Depression

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Interpersonal Therapy will improve 2 primary outcomes and 2 secondary outcomes in patients with Depression. Measurement will happen over the course of 12 months post intervention.

12 month post intervention
Work and Social Adjustment Scale (WSAS)
12 months post intervention
Edinburgh Postnatal Depression Scale (EPDS)
Symptom Checklist 20 (SCL20)
12 months post pregnancy
Presence of a Major Depressive Episode on SCID interview

Trial Safety

Trial Design

2 Treatment Groups

Behavioral: Interpersonal Therapy
1 of 2
Enhanced Usual Care
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 240 total participants across 2 different treatment groups

This trial involves 2 different treatments. Interpersonal Therapy is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Behavioral: Interpersonal Therapy
Behavioral
Individual psychotherapy that includes an initial engagement session and a total of 8 sessions. IPT focuses on psychoeducation and interpersonal skill building to decrease interpersonal conflict and increase interpersonal support and competence.
Enhanced Usual Care
Behavioral
Maternity support services (MSS) is the usual standard of care for pregnant women. A multi-disciplinary team of obstetric care providers routinely screen women for possible depression diagnosis. If a woman screens positive, she is seen by a behavioral health specialist (BHS) for further assessment and to initiate treatment, if necessary. The goals of MSS include offering services to promote healthy pregnancies and positive birth and parenting outcomes, including integrating mental health and prenatal care. Women with elevated depressive symptoms are seen by BHS throughout the pregnancy and postpartum period and then bridged to mental health treatment. BHS provides eclectic-based care but does not provide IPT.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Interpersonal Therapy
2002
Completed Phase 4
~900

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months post pregnancy
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 12 months post pregnancy for reporting.

Closest Location

University of Illinois - Urbana, IL

Eligibility Criteria

This trial is for female patients aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
English speaking
Elevated depressive symptoms based on screening with the Edinburgh Postnatal Depression Scale (EPDS) with score > 9
Adult women (over 18 years of age)
A singleton intrauterine pregnancy

Patient Q&A Section

What are the signs of depression?

"Many of the symptoms of depression were similar to features seen in chronic depression. These include feeling depressed and low energy, decreased interest in activities and reduced thoughts of suicidal ideation. The use of a DSM-IV diagnostic tool provided a more holistic view of depression by recognizing other features." - Anonymous Online Contributor

Unverified Answer

How many people get depression a year in the United States?

"Approximately 20 million Americans will have depression during their lifetime. Most will experience at least one serious episode of depression, and nearly 10% of Americans will die as a direct consequence of a major depressive episode." - Anonymous Online Contributor

Unverified Answer

Can depression be cured?

"There is no "cure-all" strategy for major depression but treatment may improve outcomes, reduce negative long-term effects, and reduce the likelihood of relapses. Effective treatment should include adequate psychotherapy, and if other medications are needed, they should be effective antidepressants." - Anonymous Online Contributor

Unverified Answer

What are common treatments for depression?

"The treatments for depression encompass both talk therapy and medication. Medications such as selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs), triptans, and venlafaxine may be helpful. Other treatments may be added to antidepressants such as low-dose bupropion, clomipramine, duloxetine, and mirtazapine. Other types of medication may be helpful, such as atypical antipsychotics (e.g. risperidone, olanzapine, quetiapine) and benzodiazepines." - Anonymous Online Contributor

Unverified Answer

What is depression?

"This article discusses the most common form of depression, which, according to WHO, affects 9.2–10% of the human population. It addresses different aspects of depression and gives statistics related to this disorder. Depression is an important health problem, affecting people of all ages. \n" - Anonymous Online Contributor

Unverified Answer

What causes depression?

"Depression is a significant health problem that may be caused by many types of environmental factors, including stress, a lack of positive experiences, and the presence of negative experiences. Other factors such as being lonely and lacking a purpose in life may also cause depression, and many people feel that they need to use drugs to manage the depressive symptoms. It is essential to understand the reasons for depression and to help those who suffer from it by offering them information and support regarding their specific cases.\n" - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating depression?

"There has definitely been one discovery in the past 30 years that has contributed to the understanding of depression and has led to new perspectives and treatments to help tackle the disease. The discovery of serotonin reuptake inhibitors provided some breakthroughs in determining depression's etiology, which is a process that has been in development for over 10 years. One key component of depression's etiology that led to these breakthroughs was the interaction of the monoaminergic and serotonergic neurotransmitters. This breakthrough led scientists to formulate a hypothesis about how monoaminergic and serotonergic neurotransmitters interact." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for depression?

"A clear consensus in the literature on response to placebo emphasizes the need for both a 'active' as well as a 'naive' group. Since those with depression are often 'naive' and the 'control' group often includes some 'experienced' patients, this consensus seems to be misleading." - Anonymous Online Contributor

Unverified Answer

Is interpersonal therapy safe for people?

"There are no reasons not to offer IPT to people with comorbid depression and alcoholism. IPT is a safe and effective intervention and there is no evidence that the comorbid dependency is detrimental." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of interpersonal therapy?

"The common side effects experienced and reported by both positive and negative clients were similar. Both positive and negative clients reported a range of side effects, some of which may impede their capacity to engage. Clinicians should be aware of the potential for patients to experience side effects." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets depression?

"Depression affects a fairly broad age range for adolescents and adults, extending from around the age of 11 to the mid-50s. In some countries, suicide is one of the top three causes of death for people of this age, and the numbers of people with depression may be rising during this time. Depression is under-investigated, under-treated and under-recognised in some countries. Although there is no cure for depression, there are a number of methods to help reduce the severity and impact. Depression affects 20-30% of people who have been diagnosed with [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) the most common cancer type in women. It is thought that in the UK this is about four times more common among women." - Anonymous Online Contributor

Unverified Answer

Does interpersonal therapy improve quality of life for those with depression?

"IPT and the co-intercouple model had beneficial effects for those with depression. Participants in both the IPT and the CC model continued to report improvement in QoL even four months after the intervention." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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