This trial is evaluating whether Interpersonal Therapy will improve 2 primary outcomes and 2 secondary outcomes in patients with Depression. Measurement will happen over the course of 12 months post intervention.
This trial requires 240 total participants across 2 different treatment groups
This trial involves 2 different treatments. Interpersonal Therapy is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"Many of the symptoms of depression were similar to features seen in chronic depression. These include feeling depressed and low energy, decreased interest in activities and reduced thoughts of suicidal ideation. The use of a DSM-IV diagnostic tool provided a more holistic view of depression by recognizing other features." - Anonymous Online Contributor
"Approximately 20 million Americans will have depression during their lifetime. Most will experience at least one serious episode of depression, and nearly 10% of Americans will die as a direct consequence of a major depressive episode." - Anonymous Online Contributor
"There is no "cure-all" strategy for major depression but treatment may improve outcomes, reduce negative long-term effects, and reduce the likelihood of relapses. Effective treatment should include adequate psychotherapy, and if other medications are needed, they should be effective antidepressants." - Anonymous Online Contributor
"The treatments for depression encompass both talk therapy and medication. Medications such as selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs), triptans, and venlafaxine may be helpful. Other treatments may be added to antidepressants such as low-dose bupropion, clomipramine, duloxetine, and mirtazapine. Other types of medication may be helpful, such as atypical antipsychotics (e.g. risperidone, olanzapine, quetiapine) and benzodiazepines." - Anonymous Online Contributor
"This article discusses the most common form of depression, which, according to WHO, affects 9.2–10% of the human population. It addresses different aspects of depression and gives statistics related to this disorder. Depression is an important health problem, affecting people of all ages. \n" - Anonymous Online Contributor
"Depression is a significant health problem that may be caused by many types of environmental factors, including stress, a lack of positive experiences, and the presence of negative experiences. Other factors such as being lonely and lacking a purpose in life may also cause depression, and many people feel that they need to use drugs to manage the depressive symptoms. It is essential to understand the reasons for depression and to help those who suffer from it by offering them information and support regarding their specific cases.\n" - Anonymous Online Contributor
"There has definitely been one discovery in the past 30 years that has contributed to the understanding of depression and has led to new perspectives and treatments to help tackle the disease. The discovery of serotonin reuptake inhibitors provided some breakthroughs in determining depression's etiology, which is a process that has been in development for over 10 years. One key component of depression's etiology that led to these breakthroughs was the interaction of the monoaminergic and serotonergic neurotransmitters. This breakthrough led scientists to formulate a hypothesis about how monoaminergic and serotonergic neurotransmitters interact." - Anonymous Online Contributor
"A clear consensus in the literature on response to placebo emphasizes the need for both a 'active' as well as a 'naive' group. Since those with depression are often 'naive' and the 'control' group often includes some 'experienced' patients, this consensus seems to be misleading." - Anonymous Online Contributor
"There are no reasons not to offer IPT to people with comorbid depression and alcoholism. IPT is a safe and effective intervention and there is no evidence that the comorbid dependency is detrimental." - Anonymous Online Contributor
"The common side effects experienced and reported by both positive and negative clients were similar. Both positive and negative clients reported a range of side effects, some of which may impede their capacity to engage. Clinicians should be aware of the potential for patients to experience side effects." - Anonymous Online Contributor
"Depression affects a fairly broad age range for adolescents and adults, extending from around the age of 11 to the mid-50s. In some countries, suicide is one of the top three causes of death for people of this age, and the numbers of people with depression may be rising during this time. Depression is under-investigated, under-treated and under-recognised in some countries. Although there is no cure for depression, there are a number of methods to help reduce the severity and impact. Depression affects 20-30% of people who have been diagnosed with [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) the most common cancer type in women. It is thought that in the UK this is about four times more common among women." - Anonymous Online Contributor
"IPT and the co-intercouple model had beneficial effects for those with depression. Participants in both the IPT and the CC model continued to report improvement in QoL even four months after the intervention." - Anonymous Online Contributor