slow-wave disruption for Depression

Phase-Based Progress Estimates
Depressionslow-wave disruption - Behavioral
25 - 50
All Sexes
What conditions do you have?

Study Summary

This trial will investigate whether a new treatment for depression, which involves manipulating sleep, can help improve mood by increasing synaptic strength.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: up to a month

up to a month
Compare indices of net synaptic strength (theta power, transcranial magnetic stimulation evoked potentials) and markers associated with plasticity (BDNF, behavioral measures of learning/memory) in individuals with MDD to healthy controls
Determine if slow-wave disruption alters mood in individuals with MDD

Trial Safety

Safety Progress

1 of 3

Similar Trials

Trial Design

2 Treatment Groups

1 of 2
Subjects with Major Depressive Disorder
1 of 2

Active Control

Experimental Treatment

60 Total Participants · 2 Treatment Groups

Primary Treatment: slow-wave disruption · No Placebo Group · N/A

Subjects with Major Depressive Disorder
Experimental Group · 1 Intervention: slow-wave disruption · Intervention Types: Behavioral
ActiveComparator Group · 1 Intervention: slow-wave disruption · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to a month

Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
1,841 Previous Clinical Trials
41,126,356 Total Patients Enrolled
64 Trials studying Depression
28,741 Patients Enrolled for Depression
Jennifer Goldschmied, PhDPrincipal InvestigatorUniversity of Pennsylvania

Eligibility Criteria

Age 25 - 50 · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are right-handed.
You have normal cognitive function.
You have a current depressive disorder.

Who else is applying?

What state do they live in?
New Jersey100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
University of Pennsylvania, Department of Psychiatry100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%