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Engage Therapy for Depression

N/A
Waitlist Available
Led By Jennifer N Bress, PhD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of unipolar major depressive disorder without psychotic features, determined by Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders (SCID)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to week 9
Awards & highlights

Study Summary

This trial will study changes in the brain during Engage, a therapy for depression in older adults, and compare them to changes during supportive therapy.

Who is the study for?
This trial is for adults aged 60 or older with major depressive disorder without psychotic features. They must be able to consent, have a certain level of depression severity, and either not be on antidepressants or on a stable dose. Participants should not have severe cognitive impairment, suicidal intent, other current serious psychiatric diagnoses, use certain psychotropic drugs, or suffer from neurological disorders or severe physical illnesses.Check my eligibility
What is being tested?
The study compares two types of therapy for late-life depression: Engage Therapy and Supportive Therapy. Over 9 weeks, participants will receive one of these therapies and undergo assessments including questionnaires, computer tasks, and EEGs to monitor brain activity changes associated with each treatment method.See study design
What are the potential side effects?
Since the interventions are psychotherapies (Engage Therapy and Supportive Therapy), they do not involve medication; therefore typical drug side effects are not expected. However, discussing emotional topics during therapy can sometimes cause temporary discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have been diagnosed with major depression, but without experiencing hallucinations or delusions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to week 9
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to week 9 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in neural response to rewarding stimuli
Secondary outcome measures
Change in behavioral activation

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Engage TherapyExperimental Treatment1 Intervention
Participants receive Engage therapy for 9 weeks.
Group II: Supportive TherapyActive Control1 Intervention
Participants receive supportive therapy for 9 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Engage Therapy
2019
N/A
~70

Find a Location

Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
1,054 Previous Clinical Trials
1,316,463 Total Patients Enrolled
66 Trials studying Depression
16,333 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,782 Previous Clinical Trials
2,689,042 Total Patients Enrolled
665 Trials studying Depression
251,369 Patients Enrolled for Depression
Jennifer N Bress, PhDPrincipal InvestigatorWeill Medical College of Cornell University

Media Library

Engage Therapy Clinical Trial Eligibility Overview. Trial Name: NCT03688139 — N/A
Depression Research Study Groups: Engage Therapy, Supportive Therapy
Depression Clinical Trial 2023: Engage Therapy Highlights & Side Effects. Trial Name: NCT03688139 — N/A
Engage Therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT03688139 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scope of enrollment for this research project?

"Affirmative. Clinicaltrials.gov documents the fact that this clinical experiment is currently recruiting, with an initial launch date of March 14th 2019 and most recent update on February 25th 2022. The trial requires 70 subjects from a single location to participate."

Answered by AI

Are there any remaining slots in this research study?

"Affirmative. Clinicaltrials.gov indicates that this medical research is recruiting participants; it was initially posted on March 14th 2019 and recently updated on February 25th 2022. 70 patients need to be recruited from one site for the trial to continue."

Answered by AI

Who else is applying?

What state do they live in?
Michigan
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
3+

How responsive is this trial?

Typically responds via
Phone Call
Recent research and studies
clinicaltrials.govStudy
Reward Function and Therapy for Late-Life Depression
2019. "Reward Function and Therapy for Late-Life Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03688139.
~11 spots leftby Apr 2025
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