Cobalt + for Wellbeing

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Pennsylvania, Philadelphia, PA
Wellbeing+3 More
Cobalt + - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

Health Care Workers and Mental Health

See full description

Eligible Conditions

  • Wellbeing
  • Anxiety
  • Depressive Symptomatology

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Cobalt + will improve 2 primary outcomes, 5 secondary outcomes, and 2 other outcomes in patients with Wellbeing. Measurement will happen over the course of 6 months.

6 months
Perceived System usability
9 months
Anxiety
DSM-5 Level 1 Cross-Cutting Symptom Measure
Depressive symptoms
Psychological well-being
Satisfaction with care
WHODAS
Well-being
Work productivity

Trial Safety

Trial Design

2 Treatment Groups

Usual Care
1 of 2
Intervention
1 of 2
Active Control
Experimental Treatment

This trial requires 1250 total participants across 2 different treatment groups

This trial involves 2 different treatments. Cobalt + is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Intervention
Behavioral
Participants will complete baseline surveys at enrollment and then complete subsequent surveys (depression, anxiety, well-being, satisfaction with access to care, work productivity) at enrollment; 0 months and then again at 6 months and 9 months. The intervention group receives usual Cobalt plus: 1) monthly automated text messaging reminders and links to Cobalt resources 2) intermittent mental health assessments which triage individuals to an appointment based on their results.
Usual CareParticipants will complete baseline surveys at enrollment and then complete subsequent surveys (depression, anxiety, well-being, satisfaction with access to care, work productivity, hours of direct patient care, percent of time providing care for patients with COVID-19) at enrollment; 0 months, 6 months, and 9 months.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 9 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 9 months for reporting.

Closest Location

University of Pennsylvania - Philadelphia, PA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
To be considered for the study, participants were required to work at least 4 hours per week in a hospital or outpatient based setting show original
The person is 18 years or older. show original
Regular, daily access to an smartphone
Being able to communicate fluently in English is a great asset. show original

Patient Q&A Section

What is wellbeing?

"Wellbeing is important to most people, especially after the age of 65. It can be used to describe the positive elements of aging, as well as to describe the key elements of happiness and health. There are many examples of people who can live a fulfilled and productive life in the face of serious illness and hardship. People who have a positive attitude are more likely to find ways to cope, cope easily, and adjust more quickly to the illness than those who have a negative attitude." - Anonymous Online Contributor

Unverified Answer

What are the signs of wellbeing?

"A key sign of wellbeing is increased enjoyment of life. Other signs include increased self-esteem, sense of control over one's behaviour, confidence, and a sense of purpose in life." - Anonymous Online Contributor

Unverified Answer

What are common treatments for wellbeing?

"A number of treatments have been proposed that might be used for wellbeing. It can be difficult to find evidence to support this, often because most reviewed meta-analyses have not been done to test and assess the quality of the studies, and so there are likely to be biases when choosing how to treat the symptoms. Many studies have been on anxiety and depression, with limited evidence of an antidepressant effect for wellbeing. However, trials with a high risk of bias were still reported, because most reviews have used low-risk and high-risk studies so mixed results are often found.\n\n- Schizophrenia and bipolar disorder are often treated with antipsychotic medication." - Anonymous Online Contributor

Unverified Answer

How many people get wellbeing a year in the United States?

"There is an urgent need in the United States to empower people to engage in and maintain their own wellbeing. The United States has been successful in this regard. But the potential of the U.S. economy to improve the wellbeing of all people depends on achieving greater equity in health, employment and earnings." - Anonymous Online Contributor

Unverified Answer

What causes wellbeing?

"The link between mood, personality and cognition is complex. Personality, emotions and well-being are related because of their interdependence. All three factors influence mood: personality is the result of emotion, and emotion, well-being and resilience are related to mood. Mental well-being is more closely related to personality, emotions and learning than simple levels of subjective quality of life. Mental and physical well-being are related to learning. There are important considerations of the relationship between psychological well-being, emotional distress and personality." - Anonymous Online Contributor

Unverified Answer

Can wellbeing be cured?

"Wellbeing cannot be cured as well. Effective treatment of both physical and mental suffering can have a significant impact on wellbeing. The World Health Organization developed a model of wellness, encompassing the physical, psychological, social, and spiritual aspects of one's life, which provides a framework through which to understand the importance of individual, family and community wellness." - Anonymous Online Contributor

Unverified Answer

Has cobalt + proven to be more effective than a placebo?

"Cobalt therapy is more effective than a placebo treatment for patients with active psoriasis, indicating that more precise and specific factors govern the skin microbiome in psoriasis. The more specific response to psoriasis treatments may be due to an increase in probiotic flora by cobalt therapy. Cobalt therapy affects the human skin microbiome and may reduce plaque psoriasis severity." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating wellbeing?

"The use of complementary and alternative medicine (CAM) is increasing. CAM is used commonly in the treatment of patients with cancer. There are a number of problems in the quality of the research, the use of a heterogeneous population, and the ethical issues. Further research is needed to produce quality research in complementary and alternative medicine, which could lead to the better use for patients with chronic disease, cancers, and also for their caregivers and for society." - Anonymous Online Contributor

Unverified Answer

Does cobalt + improve quality of life for those with wellbeing?

"At the time of this investigation, the literature did not support a significant benefit for a low dose of cobalt and a good QoL for those with well-being, but further work may have positive benefits in this area." - Anonymous Online Contributor

Unverified Answer

What does cobalt + usually treat?

"All three of the patients experienced an overall improvement in pain, fatigue, and mobility. The patients reported that they felt better about themselves and enjoyed life more as a result of the therapy. Although this is only a first small report of potential beneficial effects of cobalt + on different bodily symptoms, as well as a positive life perception, it raises the possibility that cobalt supplementation could be a beneficial therapy. The potential impact of this therapy on patient's quality of life will need to be assessed in larger, controlled studies." - Anonymous Online Contributor

Unverified Answer

Is cobalt + typically used in combination with any other treatments?

"A large number of cobalt-containing agents were used in addition to BCS. While most had no direct effect, no consistent relationship was detected between the use of these agents and clinical outcome. Furthermore, while clinicians often use cobalt as a component of these agents, the low incidence of cobalt toxicity in these studies raises the question of whether use alone is sufficient for achieving adequate treatment response rates." - Anonymous Online Contributor

Unverified Answer

How serious can wellbeing be?

"The findings from this study demonstrate a correlation between the severity of stress indicators and general happiness and satisfaction. However, while it may be seen as a possible positive consequence, if left uncontrolled, the development into depression appears to be more serious than the positive effects of wellbeing. As such, the results of this study imply that a broader awareness of health conditions, stresses and general wellbeing should be explored in order to better understand factors which may lead in the development of a more serious situation." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Wellbeing by sharing your contact details with the study coordinator.