This trial is evaluating whether Cobalt + will improve 2 primary outcomes, 5 secondary outcomes, and 2 other outcomes in patients with Wellbeing. Measurement will happen over the course of 6 months.
This trial requires 1250 total participants across 2 different treatment groups
This trial involves 2 different treatments. Cobalt + is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"Wellbeing is important to most people, especially after the age of 65. It can be used to describe the positive elements of aging, as well as to describe the key elements of happiness and health. There are many examples of people who can live a fulfilled and productive life in the face of serious illness and hardship. People who have a positive attitude are more likely to find ways to cope, cope easily, and adjust more quickly to the illness than those who have a negative attitude." - Anonymous Online Contributor
"A key sign of wellbeing is increased enjoyment of life. Other signs include increased self-esteem, sense of control over one's behaviour, confidence, and a sense of purpose in life." - Anonymous Online Contributor
"A number of treatments have been proposed that might be used for wellbeing. It can be difficult to find evidence to support this, often because most reviewed meta-analyses have not been done to test and assess the quality of the studies, and so there are likely to be biases when choosing how to treat the symptoms. Many studies have been on anxiety and depression, with limited evidence of an antidepressant effect for wellbeing. However, trials with a high risk of bias were still reported, because most reviews have used low-risk and high-risk studies so mixed results are often found.\n\n- Schizophrenia and bipolar disorder are often treated with antipsychotic medication." - Anonymous Online Contributor
"There is an urgent need in the United States to empower people to engage in and maintain their own wellbeing. The United States has been successful in this regard. But the potential of the U.S. economy to improve the wellbeing of all people depends on achieving greater equity in health, employment and earnings." - Anonymous Online Contributor
"The link between mood, personality and cognition is complex. Personality, emotions and well-being are related because of their interdependence. All three factors influence mood: personality is the result of emotion, and emotion, well-being and resilience are related to mood. Mental well-being is more closely related to personality, emotions and learning than simple levels of subjective quality of life. Mental and physical well-being are related to learning. There are important considerations of the relationship between psychological well-being, emotional distress and personality." - Anonymous Online Contributor
"Wellbeing cannot be cured as well. Effective treatment of both physical and mental suffering can have a significant impact on wellbeing. The World Health Organization developed a model of wellness, encompassing the physical, psychological, social, and spiritual aspects of one's life, which provides a framework through which to understand the importance of individual, family and community wellness." - Anonymous Online Contributor
"Cobalt therapy is more effective than a placebo treatment for patients with active psoriasis, indicating that more precise and specific factors govern the skin microbiome in psoriasis. The more specific response to psoriasis treatments may be due to an increase in probiotic flora by cobalt therapy. Cobalt therapy affects the human skin microbiome and may reduce plaque psoriasis severity." - Anonymous Online Contributor
"The use of complementary and alternative medicine (CAM) is increasing. CAM is used commonly in the treatment of patients with cancer. There are a number of problems in the quality of the research, the use of a heterogeneous population, and the ethical issues. Further research is needed to produce quality research in complementary and alternative medicine, which could lead to the better use for patients with chronic disease, cancers, and also for their caregivers and for society." - Anonymous Online Contributor
"At the time of this investigation, the literature did not support a significant benefit for a low dose of cobalt and a good QoL for those with well-being, but further work may have positive benefits in this area." - Anonymous Online Contributor
"All three of the patients experienced an overall improvement in pain, fatigue, and mobility. The patients reported that they felt better about themselves and enjoyed life more as a result of the therapy. Although this is only a first small report of potential beneficial effects of cobalt + on different bodily symptoms, as well as a positive life perception, it raises the possibility that cobalt supplementation could be a beneficial therapy. The potential impact of this therapy on patient's quality of life will need to be assessed in larger, controlled studies." - Anonymous Online Contributor
"A large number of cobalt-containing agents were used in addition to BCS. While most had no direct effect, no consistent relationship was detected between the use of these agents and clinical outcome. Furthermore, while clinicians often use cobalt as a component of these agents, the low incidence of cobalt toxicity in these studies raises the question of whether use alone is sufficient for achieving adequate treatment response rates." - Anonymous Online Contributor
"The findings from this study demonstrate a correlation between the severity of stress indicators and general happiness and satisfaction. However, while it may be seen as a possible positive consequence, if left uncontrolled, the development into depression appears to be more serious than the positive effects of wellbeing. As such, the results of this study imply that a broader awareness of health conditions, stresses and general wellbeing should be explored in order to better understand factors which may lead in the development of a more serious situation." - Anonymous Online Contributor