Stannous Fluoride Toothpaste + CPC Mouthwash for Gum Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
The aim of this study is to assess the ability of a marketed Cetylpyridinium Chloride (CPC) mouthwash alongside a marketed Stannous Fluoride (SnF2) toothpaste in improving gingival health and reducing plaque accumulation, compared to the use of a regular fluoride toothpaste alone in participants with clinically measurable plaque-induced gingivitis.
Do I need to stop taking my current medications to join the trial?
Yes, you may need to stop certain medications. You cannot take antibiotics, anti-inflammatory drugs, anticoagulants, immunosuppressants, or certain herbal remedies within 4 weeks before the trial or during the study. Also, you cannot use antibacterial toothpaste or mouthwash that could affect plaque or gingivitis measurements.
What safety data exists for Stannous Fluoride Toothpaste and CPC Mouthwash for gum disease?
The provided research primarily focuses on the efficacy of cetylpyridinium chloride (CPC) and sodium fluoride in mouthrinses for controlling dental plaque and gingivitis. While these studies demonstrate the antibacterial and antiplaque properties of CPC and fluoride, they do not specifically address safety data. However, the studies imply that these ingredients are used in clinical settings, suggesting a level of safety for oral use. For comprehensive safety data, further investigation into specific safety studies or clinical trials would be necessary.12345
Is Cetylpyridinium Chloride Mouthwash, Stannous Fluoride Toothpaste a promising treatment for gum disease?
What data supports the idea that Stannous Fluoride Toothpaste + CPC Mouthwash for Gum Disease is an effective treatment?
The available research shows that mouthwashes containing cetylpyridinium chloride (CPC) and sodium fluoride can help reduce dental plaque and gingivitis. One study found that a mouthwash with CPC and sodium fluoride was more effective in controlling plaque and gingivitis than a control mouthwash with only sodium fluoride. Another study demonstrated that a CPC mouthwash significantly reduced plaque and gingivitis over six months. Additionally, a CPC rinse showed a 25% reduction in plaque compared to a placebo, which was similar to the effectiveness of a leading essential oils mouthwash. These findings suggest that Stannous Fluoride Toothpaste combined with CPC Mouthwash can be an effective treatment for gum disease.128910
Are You a Good Fit for This Trial?
This trial is for individuals with plaque-induced gingivitis, which means they have gum disease and a noticeable buildup of plaque on their teeth. Participants should be looking to improve their gum health.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants use SnF2 toothpaste and CPC mouthwash or control toothpaste twice daily for 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cetylpyridinium Chloride Mouthwash
- Stannous Fluoride Toothpaste
Cetylpyridinium Chloride Mouthwash is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
HALEON
Lead Sponsor