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Fluoride Treatment

Silver Diamine Fluoride 38% for Tooth Decay (SDF Trial)

N/A
Waitlist Available
Led By Michael Kanellis, DDS, MS
Research Sponsored by Justine Kolker
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 12 months after blinded treatment with either silver diamine fluoride 38% or placebo (sterile water)
Awards & highlights

SDF Trial Summary

This study is evaluating whether silver diamine fluoride (SDF) is effective in preventing caries in healthy adults.

SDF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 12 months after blinded treatment with either silver diamine fluoride 38% or placebo (sterile water)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 12 months after blinded treatment with either silver diamine fluoride 38% or placebo (sterile water) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Assessment of Radiographic Change in Dental Cavity
Secondary outcome measures
Incidence of caries in all other teeth in the study subject

SDF Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Silver Diamine Fluoride 38%Active Control1 Intervention
Group 1 (SDF 38%) will receive the application of silver diammine fluoride (38% SDF solution) in addition to 5% sodium fluoride varnish to each approximal carious lesion (scores RA1,RA2,RA3) in a posterior tooth (premolar or molar) that is in contact with an adjacent tooth, using super floss, for a duration of 3 minutes under rubber dam isolation.
Group II: Placebo (Sterile water)Placebo Group1 Intervention
Group 2 Placebo (control) will receive the application of sterile water (placebo) in addition to 5% sodium fluoride varnish to each approximal carious lesion (scores RA1,RA2,RA3) in a posterior tooth (premolar or molar) that is in contact with an adjacent tooth, using super floss, for a duration of 3 minutes under rubber dam isolation.

Find a Location

Who is running the clinical trial?

Justine KolkerLead Sponsor
Michael Kanellis, DDS, MSPrincipal InvestigatorUniversity of Iowa
Justine Kolker, DDS, MSPrincipal InvestigatorUniversity of Iowa

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Journal of Dental ResearchJournal
Silver Diamine Fluoride: A Caries “silver-fluoride Bullet
Rosenblatt, A., T.C.M. Stamford, and R. Niederman. 2009. “Silver Diamine Fluoride: A Caries “silver-fluoride Bullet””. Journal of Dental Research. SAGE Publications. doi:10.1177/0022034508329406.
clinicaltrials.govStudy
Silver Diamine Fluoride Pilot Study (SDF)
Justine Kolker 2016. "Silver Diamine Fluoride Pilot Study (SDF)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02591147.
~4 spots leftby Apr 2025
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