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Behavioral Intervention

Resistance exercise training for Mini Stroke

N/A
Waitlist Available
Led By Thalia Field, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 months, 12 months
Awards & highlights

Study Summary

This trial will test whether a resistance exercise training program can help improve cognitive function in older adults with vascular cognitive impairment, compared to a stretch and relaxation program.

Eligible Conditions
  • Mini Stroke
  • Vascular Dementia
  • Vascular Cognitive Impairment

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 months, 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 months, 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in white matter health as measured by total white matter lesion volume
Cognitive function as measured by Alzheimer's Disease Assessment Scale Cognitive Subscale Plus (ADAS-Plus)
Secondary outcome measures
Arterial stiffness as measured by carotid-femoral arterial pulse-wave velocity (PWV) (subset only)
Cardiometabolic risk factors as measured by blood panel (subset only)
Cardiometabolic risk factors as measured by body mass index
+29 more

Side effects data

From 2015 Phase 3 trial • 50 Patients • NCT02188849
18%
Pain
14%
Falls
14%
Gastroinftestinal symptoms
5%
Fever
100%
80%
60%
40%
20%
0%
Study treatment Arm
Creatine
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Resistance Training (RT)Experimental Treatment1 Intervention
The RT program will be a twice-weekly program. A pressurized air system and free weights will be used . The pressurized air system exercises will consist of biceps curls, triceps extension, seated row, latissmus dorsi pull downs, leg press, hamstring curls, and calf raises. Other exercises, with free weights, will include mini-squats, mini-lunges, and lunge walks. The intensity of the training stimulus will initially be at 50% to 60% of 1 repetition maximum (RM) as determined at week two, and progress to 75% to 85% of 1-RM at a work level of 6 to 8 repetitions (2 sets) by week four. The training stimulus will be increased using the 7 RM method. To meet the public health mandates of COVID-19, when it is necessary, training will occur at home, with the use of a set of resistance bands of various weights. Participants will be provided access to instructional videos either by YouTube or DVD. They will be called on a weekly basis to monitor progress and compliance.
Group II: Stretching and Relaxation (CON)Active Control1 Intervention
The CON program will be a twice-weekly program. The CON group will consist of stretching exercises, basic core-strength/kegal exercises, and relaxation techniques. Other than bodyweight, no additional loading (e.g., hand weights, resistance bands, etc.) will be applied to any of the exercises. To meet the public health mandates of COVID-19, when it is necessary, training will occur at home. Participants will be provided access to instructional videos either by YouTube or DVD. They will be called on a weekly basis to monitor progress and compliance.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Resistance exercise training
2016
Completed Phase 3
~800

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,410 Previous Clinical Trials
1,766,480 Total Patients Enrolled
Thalia Field, MDPrincipal InvestigatorUniversity of British Columbia
Ging-Yuek Robin Hsiung, MD, PhDPrincipal InvestigatorUniversity of British Columbia
1 Previous Clinical Trials
216 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
TrialsJournal
Reshaping the Path of Vascular Cognitive Impairment with Resistance Training: A Study Protocol for a Randomized Controlled Trial
Liu-Ambrose, Teresa, Elizabeth Dao, Rachel A. Crockett, Cindy K. Barha, Ryan S. Falck, John R. Best, Ging-Yeuk R. Hsiung, et al.. 2021. “Reshaping the Path of Vascular Cognitive Impairment with Resistance Training: A Study Protocol for a Randomized Controlled Trial”. Trials. Springer Science and Business Media LLC. doi:10.1186/s13063-021-05156-1.
clinicaltrials.govStudy
Reshaping the Path of Vascular Cognitive Impairment (VCI)
Teresa Liu-Ambrose 2016. "Reshaping the Path of Vascular Cognitive Impairment (VCI)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02669394.
~10 spots leftby Apr 2025
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