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Speech Therapy for Post-Stroke Affective Aprosodia
N/A
Waitlist Available
Led By Argye E Hillis, MD, MA
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Ischemic stroke to the right cerebral hemisphere
Normal or corrected-to-normal hearing and vision via screening tasks and self-report
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1 week after phase i intervention, 1 week after phase ii intervention
Awards & highlights
Study Summary
This trial looks at whether a speech and language therapy can help improve emotional prosody recognition and production deficits in people who have had a right hemisphere stroke.
Who is the study for?
This trial is for adults aged 18-89 who've had a stroke in the right side of their brain, can consent to participate, speak English fluently as per self-report before the stroke, and are medically stable. They should not have severe cognitive issues or depression, significant neurological diseases other than certain types of strokes, or be on medications affecting speech processing.Check my eligibility
What is being tested?
The study tests a behavioral treatment aimed at improving recognition and expression of emotional tones in speech (affective aprosodia) after a recent right hemisphere stroke. Participants will either receive this specialized intervention or no intervention to compare outcomes.See study design
What are the potential side effects?
Since this is a behavioral intervention focusing on speech therapy rather than medication, traditional physical side effects are not expected. However, participants may experience frustration or fatigue during therapy sessions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I had a stroke in the right side of my brain.
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My hearing and vision are normal, or corrected to normal.
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I can give my consent or have someone who can consent for me.
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I am between 18 and 89 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 1 week after all treatment, 4 weeks after all treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 1 week after all treatment, 4 weeks after all treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Behavioral and neurological predictors of aprosodia intervention outcomes
Change in accuracy on affective prosody expression following aprosodia intervention compared to spontaneous recovery
Change in accuracy on affective prosody recognition following aprosodia intervention compared to spontaneous recovery
+3 moreSecondary outcome measures
Change in standardized acoustic features (rate, frequency, intensity, rhythm), on standardized measures of prosody expression
Other outcome measures
Change in accuracy on Discourse Comprehension Test
Change in accuracy on affective prosody expression
Change in accuracy on affective prosody recognition
+4 moreTrial Design
5Treatment groups
Experimental Treatment
Active Control
Group I: Implicit Receptive Prosody InterventionExperimental Treatment1 Intervention
Implicit cues will be provided to help participants improve recognition of targeted affective prosody.
Group II: Implicit Expressive Prosody InterventionExperimental Treatment1 Intervention
Implicit cues will be provided to help participants improve expression of targeted affective prosody.
Group III: Explicit Receptive Prosody InterventionExperimental Treatment1 Intervention
Explicit cues will be provided to help participants improve recognition of targeted affective prosody.
Group IV: Explicit Expressive Prosody InterventionExperimental Treatment1 Intervention
Explicit cues will be provided to help participants improve expression of targeted affective prosody.
Group V: No-InterventionActive Control1 Intervention
Sessions will comprise conversation about current events, recovery progress (including speech therapy goals targeted in outside intervention [if relevant]), hobbies, and other similar topics.
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Who is running the clinical trial?
Johns Hopkins UniversityLead Sponsor
2,259 Previous Clinical Trials
14,820,653 Total Patients Enrolled
33 Trials studying Stroke
28,922 Patients Enrolled for Stroke
Argye E Hillis, MD, MAPrincipal InvestigatorJohns Hopkins University
1 Previous Clinical Trials
80 Total Patients Enrolled
1 Trials studying Stroke
80 Patients Enrolled for Stroke
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I have been diagnosed with severe depression.You have not corrected any hearing or vision problems.I had a stroke in the right side of my brain.I have no significant brain diseases or injuries, except for minor strokes or TIAs that didn't cause symptoms.My hearing and vision are normal, or corrected to normal.You show difficulty understanding or expressing emotions in a standardized test.You do not have serious problems with thinking and memory (MoCA score is higher than 9).You do not have significant difficulty speaking.My health condition is currently stable.I am unable to understand or give consent for treatment.I am currently in speech therapy for aprosodia.You are not extremely sad or down (PHQ-9 score less than 20).You have significant difficulty speaking clearly or moving your mouth and tongue.I have had a stroke or serious brain condition.I had a stroke in the left side of my brain or a bleeding stroke in the right side.I am under 18 or over 90 years old.I am in speech therapy that does not focus on flat tone of voice.I am taking medication that could affect my speech rhythm.I am not on medication that affects speech patterns.I can give my consent or have someone who can consent for me.You have trouble understanding or expressing emotions through speech.I am between 18 and 89 years old.You have a severe problem with thinking and remembering things (MoCA score less than 16).
Research Study Groups:
This trial has the following groups:- Group 1: Explicit Expressive Prosody Intervention
- Group 2: No-Intervention
- Group 3: Explicit Receptive Prosody Intervention
- Group 4: Implicit Expressive Prosody Intervention
- Group 5: Implicit Receptive Prosody Intervention
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this trial available to individuals aged 45 or more?
"This particular medical study is only open to patients aged between 18 and 89 years. Conversely, there are 61 trials targeting minors while 1390 clinicals studies focus on individuals over 65."
Answered by AI
Is this trial enrolling volunteers at the present time?
"Evidence on clinicaltrials.gov suggests that this specific trial is not allocating any more openings to participants but when it was posted, February 1st 2021 and last updated June 10th 2022. Fortunately, over 1400 other studies are currently recruiting patients at the moment."
Answered by AI
Does my profile meet the qualifications for this experiment?
"The eligibility criteria for this trial necessitates that potential participants have dementia and are within their 18th to 89th year. This clinical study is still in need of 5 volunteers."
Answered by AI
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