20 Participants Needed

Electrolyte Drinks for Dehydration

(LIV-D2O Trial)

SK
Overseen ByStavros Kavouras, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Arizona State University

What You Need to Know Before You Apply

What is the purpose of this trial?

It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are on thyroid medication.

Is it safe to use electrolyte drinks for dehydration?

Research shows that oral rehydration solutions (ORS), including those with glucose and electrolytes, are generally safe for treating dehydration in humans, including children with gastroenteritis. No adverse effects were reported in studies, but it's important to use the correct formulation for specific conditions, like cholera, to avoid complications such as low sodium levels.12345

How is the treatment Liquid IV Hydration Multiplier different from other treatments for dehydration?

Liquid IV Hydration Multiplier is unique because it offers a convenient oral rehydration solution (ORS) that can be used at home, combining electrolytes and glucose to effectively rehydrate the body. Unlike some traditional ORS formulations, it may provide a more balanced electrolyte composition suitable for both cholera and non-cholera dehydration, potentially reducing the risk of complications like hyponatremia (low sodium levels).12467

Are You a Good Fit for This Trial?

This trial is for adults aged 18-60 who exercise at least twice a week and have maintained a stable weight (less than 5 pounds change) over the last two months. It's not suitable for those with night shift work, on thyroid meds, past bariatric surgery, or with heart, kidney, liver diseases. Also excluded are those in another study or weighing over 110 pounds.

Inclusion Criteria

Training at least 2 times per week
Stable weight for the last 2 months (fluctuation less than 5 pounds)

Exclusion Criteria

I have a heart condition.
Night shifting work
I have had weight loss surgery.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo rehydration with either a carbohydrate-electrolyte solution or water following exercise-induced dehydration

4 hours
1 visit (in-person)

Follow-up

Participants are monitored for rehydration effectiveness and physiological responses

4 hours
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Liquid IV Hydration Multiplier
  • Liquid IV Sugar Free
Trial Overview The study tests how well different drinks rehydrate after exercise-induced dehydration: plain water versus Liquid IV Sugar Free and Liquid IV Hydration Multiplier—both containing electrolytes and glucose which may enhance fluid intake and reduce urine output.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Placebo Group
Group I: Low Sugar electrolyte solutionExperimental Treatment1 Intervention
Group II: Carbohydrate Electrolyte solutionExperimental Treatment1 Intervention
Group III: WaterPlacebo Group1 Intervention

Liquid IV Hydration Multiplier is already approved in European Union, United States, United Kingdom for the following indications:

🇪🇺
Approved in European Union as Oral Rehydration Solution (ORS) for:
🇺🇸
Approved in United States as Oral Rehydration Therapy (ORT) for:
🇬🇧
Approved in United Kingdom as Oral Rehydration Solution (ORS) for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

Arizona State University

Lead Sponsor

Trials
311
Recruited
109,000+

Published Research Related to This Trial

Oral rehydration therapy (ORT) using glucose-electrolyte solutions is a highly effective treatment for acute diarrheal diseases, recognized as one of the major therapeutic advancements of the century.
The World Health Organization's recommended oral rehydration solution (ORS) is widely used and has potential applications beyond diarrhea, including in patients with short bowel syndrome and post-surgical recovery.
Oral rehydration therapy.Farthing, MJ.[2019]
In a study involving 26 healthy adults, an amino acid-based oral rehydration therapy (ORT) beverage showed significantly better fluid retention (75% vs 57%) and improved restoration of interstitial fluid volume compared to a glucose-based sports drink after hypertonic dehydration.
During isotonic dehydration, the amino acid beverage also outperformed the sports drink in electrolyte replacement and preservation of interstitial fluid volume, indicating its potential as a more effective rehydration option.
Efficacy of Glucose or Amino Acid-Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration.Cheuvront, SN., Kenefick, RW., Charkoudian, N., et al.[2019]
A new oral rehydration solution (ORS) called reformulated Dioralyte (RD) was tested in a double-blind trial with 32 children suffering from acute gastroenteritis, showing no adverse effects from either RD or the standard Dioralyte (SD).
Both RD and SD had similar efficacy in terms of fluid intake, weight change, and stool frequency, indicating that RD, with its lower osmolality, is as effective as the standard solution for rehydration in children.
Clinical experience with a hypotonic oral rehydration solution for treatment of pediatric gastroenteritis in the United Kingdom.Elliott, EJ., Walker-Smith, JA., Farthing, MJ., et al.[2016]

Citations

Oral rehydration therapy. [2019]
Efficacy of Glucose or Amino Acid-Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration. [2019]
Clinical experience with a hypotonic oral rehydration solution for treatment of pediatric gastroenteritis in the United Kingdom. [2016]
Issues and Controversies in the Evolution of Oral Rehydration Therapy (ORT). [2022]
Post-exercise rehydration: Comparing the efficacy of three commercial oral rehydration solutions. [2023]
Role of oral rehydration therapy in controlling epidemic of cholera and watery diarrhoea. [2004]
Simplified treatment strategies to fluid therapy in diarrhea. [2018]
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