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Paragonix SherpaPak Cardiac Transport System for Determination of Death

N/A
Waitlist Available
Led By Marian Urban, MD, PhD
Research Sponsored by University of Nebraska
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial will test whether a new system for transporting hearts for transplant is safe and effective.

Eligible Conditions
  • Heart Transplant
  • Determination of Death
  • Outcomes Research
  • Extracorporeal Membrane Oxygenation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Primary Graft Dysfunction (PGD)
Secondary outcome measures
Duration of vasoactive-inotropic support in days
Intensive Care Unit & Hospital length of stay in days
Need for cardioversion or pacing to restart transplanted heart
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: SherpaPakExperimental Treatment1 Intervention
cardiac allografts recovered from donors after circulatory determined death using thoracoabdominal normothermic regional perfusion will be transported to the recipient center in Paragonix SherpaPak Cardiac Transport System
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Paragonix SherpaPak Cardiac Transport System
2021
N/A
~10

Find a Location

Who is running the clinical trial?

University of NebraskaLead Sponsor
539 Previous Clinical Trials
1,144,729 Total Patients Enrolled
1 Trials studying Determination of Death
10 Patients Enrolled for Determination of Death
Marian Urban, MD, PhDPrincipal InvestigatorAssistant Professor
1 Previous Clinical Trials
10 Total Patients Enrolled
1 Trials studying Determination of Death
10 Patients Enrolled for Determination of Death

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Journal of Thoracic DiseaseJournal
First Clinical Experience with the Novel Cold Storage Sherpapaktm System for Donor Heart Transportation
Radakovic, Dejan, Seymur Karimli, Kiril Penov, Ina Schade, Khaled Hamouda, Constanze Bening, Rainer G. Leyh, and Ivan Aleksic. 2020. “First Clinical Experience with the Novel Cold Storage Sherpapaktm System for Donor Heart Transportation”. Journal of Thoracic Disease. AME Publishing Company. doi:10.21037/jtd-20-1827.
International Journal of Molecular SciencesJournal
Targeting the Innate Immune Response to Improve Cardiac Graft Recovery After Heart Transplantation: Implications for the Donation After Cardiac Death
Toldo, Stefano, Mohammed Quader, Fadi Salloum, Eleonora Mezzaroma, and Antonio Abbate. 2016. “Targeting the Innate Immune Response to Improve Cardiac Graft Recovery After Heart Transplantation: Implications for the Donation After Cardiac Death”. International Journal of Molecular Sciences. MDPI AG. doi:10.3390/ijms17060958.
The Journal of Heart and Lung TransplantationJournal
Report from a Consensus Conference on Primary Graft Dysfunction After Cardiac Transplantation
Kobashigawa, Jon, Andreas Zuckermann, Peter Macdonald, Pascal Leprince, Fardad Esmailian, Minh Luu, Donna Mancini, et al.. 2014. “Report from a Consensus Conference on Primary Graft Dysfunction After Cardiac Transplantation”. The Journal of Heart and Lung Transplantation. Elsevier BV. doi:10.1016/j.healun.2014.02.027.
Journal of AnesthesiaJournal
Vasoactive-inotropic Score as a Predictor of Morbidity and Mortality in Adults After Cardiac Surgery with Cardiopulmonary Bypass
Yamazaki, Yumiko, Koji Oba, Yoshiro Matsui, and Yuji Morimoto. 2018. “Vasoactive-inotropic Score as a Predictor of Morbidity and Mortality in Adults After Cardiac Surgery with Cardiopulmonary Bypass”. Journal of Anesthesia. Springer Science and Business Media LLC. doi:10.1007/s00540-018-2447-2.
~1 spots leftby Apr 2025
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