Contrast-enhanced ultrasound for Kidney, Cystic

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
St. Joseph's Healthcare Hamilton, Hamilton, Canada
Kidney, Cystic+2 More
Contrast-enhanced ultrasound - Procedure
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether contrast-enhanced ultrasound can be used to evaluate complex renal cysts.

See full description

Eligible Conditions

  • Kidney, Cystic
  • Renal Cyst Complex

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Contrast-enhanced ultrasound will improve 1 primary outcome and 2 secondary outcomes in patients with Kidney, Cystic. Measurement will happen over the course of Baseline imaging (CEUS 14 days within a CT scan).

Month 12
concordance between CEUS and CT
Baseline and every three months until the end of study.
histopathological diagnosis after surgery of complex renal cysts
Day 14
Average percent difference of CEUS vs CT imaging

Trial Safety

Trial Design

1 Treatment Group

Contrast-enhanced ultrasound
1 of 1
Experimental Treatment

This trial requires 40 total participants across 1 different treatment group

This trial involves a single treatment. Contrast-enhanced Ultrasound is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Contrast-enhanced ultrasound
Procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Contrast-enhanced ultrasound
2019
N/A
~180

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and every three months until the end of study.
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline and every three months until the end of study. for reporting.

Who is running the study

Principal Investigator
A. K.
Anil Kapoor, MD, FRCSC
St. Joseph's Healthcare Hamilton

Closest Location

St. Joseph's Healthcare Hamilton - Hamilton, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
have a cyst wall evaluation All patients who have a CT scan of their kidneys to evaluate complex renal cysts will have a cyst wall evaluation. show original
The person must be at least 18 years old and understand what they are consenting to. show original
A complex renal cyst defined as Bosniak IIF, III or IV

Patient Q&A Section

What are common treatments for cysts?

"The most common treatment methods were EMR and aspiration alone. Ultrasound-based aspiration alone is a highly effective treatment and is safer than EMR combined with the application of a cyst fluid sample to eliminate the possibility of infectious spread." - Anonymous Online Contributor

Unverified Answer

Can cysts be cured?

"A small proportion can be cured with surgery because the treatment is not effective in all cases. The rest should continue to be looked after medically. Treatment need not be complicated, only thorough observation and regular follow-up by a medical practitioner. Further research is needed as the exact efficacy and safety is yet to be determined." - Anonymous Online Contributor

Unverified Answer

What causes cysts?

"There is a good correlation between the presence of a cyst and the presence of a lesion, but this correlation is not complete. No single underlying cause for all cysts has been identified. Cysts form in the prostatic epithelium. The cells within the epithelium secrete the lining lining fluid which is constantly replaced. Over time, the fluid collects in the spaces behind the epithelium. This fluid can collect into a nodule, or cyst if it is lined by fibrous tissue. Some of these lined pockets may become infected. If this occurs then the cyst will become inflamed and the symptoms of the infection become worse. At this stage a diagnosis of the infection can be made without biopsy." - Anonymous Online Contributor

Unverified Answer

What are the signs of cysts?

"Cysts such as ovarian cysts in women or kidney cysts in men can present with a variety of symptoms. Some common symptoms include upper abdominal pain, haematuria, and abdominal distention." - Anonymous Online Contributor

Unverified Answer

How many people get cysts a year in the United States?

"About 674,200 people in the United States develop cysts a year. Of these people, 47,800 women and 28,400 men will develop breast cysts. Most female developing breast cysts will resolve and their males will develop a skin cyst. Skin cysts will resolve in around 15% of females with breast cysts and will disappear in the remainder of affected women in time. More females will develop breast cysts than will develop breast cysts in their same-sex husbands. Female-to-female cyst couples will almost always develop cysts simultaneously. Skin cysts affect males-to-same-sex couples almost always. There is also a gender association with cysts and the likelihood of developing them." - Anonymous Online Contributor

Unverified Answer

What is cysts?

"Cysts can be categorized as encapsulated or non encasped one. They can be classified into two different types of cysts: walled and unwalled. These types of cyst can be differentiated by assessing the number of epithelial lining cells in them. Non-encapsulated cysts (wallone) are benign, while encapsulated cysts (wall two) can be an indication of malignant tumor in the form of rhabdomyoma. Thus, we need to consider the composition of the cyst lining in order to distinguish between unencapsulated cysts and encapsulated cysts. Cytogenetic analysis is also a reliable non-invasive method to provide information regarding cyst lining cells." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets cysts?

"There is little consistency on the age at which someone becomes pre-menopausal. Because the average age of onset is inconsistent, the average age at which symptoms occur, and which surgical therapy is effective, we propose that the average age of onset be changed to 54 years." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of contrast-enhanced ultrasound?

"In summary, the prevalence and severity of all AEs were low in the studied population. Most AEs occurred early after or within 24 h of contrast-enhanced US scanning. The frequency of grade ≥2 AEs was statistically higher in the low incidence scan compared with the high incidence scan, as was the incidence of a grade ≥2 AEs. Further studies are required to validate these findings." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in contrast-enhanced ultrasound for therapeutic use?

"CEUS has progressed rapidly since its introduction into the field of ultrasonography in the mid-1990s and remains a viable and reliable technique for evaluating and differentiating between normal and neoplastic tissues. CEUS may play an important role in the diagnosis and prediction of malignancy in tumors." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving contrast-enhanced ultrasound?

"This is a limited survey of reported clinical trials using sonographic examinations to assess the anatomy of the lower extremity. The available data are limited to observational studies with no conclusions can be drawn regarding which techniques are clinically more effective. Further studies are needed to evaluate the clinical value of contrast-enhanced sonography." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for cysts?

"• The overall survival rate for patients with cysts after surgical resection is very high, especially for patients who present with a nonadhesive papillary cystic neoplasm and benign nonfunctioning cysts. • Cysts without malignant features that are resected after surgical resection have the highest overall long-term survival rate (91.9% rate) compared with patients with malignant cysts of different types (57.1-65.6%)." - Anonymous Online Contributor

Unverified Answer

How quickly does cysts spread?

"There was no statistically significant difference in the time it took to find symptomatic bladder calculi between men and women, and the time it took to find asymptomatic calculi did not vary significantly with age or race. However, we found no women over the age of 80 who did not test positive for calculi after one year." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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