This trial is evaluating whether INhance with Trihex Technology will improve 3 primary outcomes and 1 secondary outcome in patients with Dermatochalasis. Measurement will happen over the course of Up to 2 weeks post blepharoplasty surgery.
This trial requires 10 total participants across 2 different treatment groups
This trial involves 2 different treatments. INhance With Trihex Technology is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"We have found 3 new causative mutations in the ELN gene and propose for the first time that ELN pathogenic variants are associated with cutis laxa." - Anonymous Online Contributor
"There are a number of treatment options for cutis laxa; however, studies have not been done to determine long-term effectiveness. The use of skin grafts from donor sites which are unaffected by the condition is an option. It is also possible to use silicone elastomers to produce a soft, flexible and durable soft foam. However, this material must be changed every two to five years and is expensive. There are other cosmetic options, such as use of topical medications and laser treatments. These treatments can be used to improve the appearance, and to improve the strength of elastic fibers. They can also reduce scarring." - Anonymous Online Contributor
"Oral antibiotics are used to treat cutis laxa with cutaneous fistulas, and topical antibiotics can be used to treat cutis laxa without cutaneous fistulas. Skin excision, in combination with skin grafting is the definitive method to treat cutis laxa." - Anonymous Online Contributor
"Cutis laxa is characterised by skin folds, folds around the abdomen (sacral) creases and a thickened and wrinkled skin. These symptoms are caused by a loss of collagen in the connective tissues." - Anonymous Online Contributor
"There is an average of 0.8 new cases of cutis laxusa per million population per year in the United States. The estimated prevalence of cutis laxa in the US populations is 8.1 in 2000. Subjects who are affected by cutis laxa usually start having symptoms during adulthood. There is no clear pattern to the age of onset of the symptoms." - Anonymous Online Contributor
"In a recent study, findings of this study indicate that most affected patients can be treated successfully with minimal side effects; this is probably due not to the cause of cutis laxa, but rather to the underlying disorder-the autonomic nervous system, which may be the most easily changeable part of the patient's body." - Anonymous Online Contributor
"There is no single "right" or single "wrong" treatment for patients with cutis laxa or atopic dermatitis. A patient's condition and expectations will influence treatment choices. Patients with cutis laxa typically require a combination of treatments, some which have limited efficacy, such as corticosteroids, and some that have proven efficacy, such as isotretinoin, for long-term treatment." - Anonymous Online Contributor
"A high proportion of subjects with cutis laxa have a family history of the disease. The familial penetrance is estimated at 68% in this study. [Cutis laxa is most prevalent in subjects >20 years old." - Anonymous Online Contributor
"The novel, air-stable, bi-lobal device allows to treat small skin lesions, such as ichthyosis, lichenified skin, psoriasis, and atopic conditions. The 3-fold enhancement in the cutaneous absorption of trihex correlates with the enhanced skin permeability and enhanced absorption of trihex in a mouse model of skin inflammation and psoriasis. Furthermore, in this pilot study, treatment of atopic dermatitis patients using the BID device showed the effectiveness and safety of the BID device in atopic dermatitis treatment." - Anonymous Online Contributor
"Although cutis laxa is a genetic condition, the penetrance of cutis laxa is still relatively high between first-degree relatives. Patients with cutis laxa should be assessed in the context of the family history which may provide insight into the mode of inheritance and help in the genetic counselling of the patient." - Anonymous Online Contributor
"Many patients have symptoms that can preclude them from doing strenuous exercise. Furthermore, many older patients report that they are disabled by cutis laxa. Patients who have low BMI values should be questioned by their physician as to possible exercise limitations." - Anonymous Online Contributor
"Although the potential effect of inhance on skin barrier function is of concern, there is no evidence that inhance with trihex is associated with increased rates of skin reactions suggestive of cutis laxa." - Anonymous Online Contributor