Treatment for Cryptosporidiosis

Phase-Based Progress Estimates
Romark Laboratories LC, Tampa, FL
Cryptosporidiosis+1 More
Any Age
All Sexes
What conditions do you have?

Study Summary

This study is evaluating whether a drug called nitazoxanide can be used to treat AIDS patients suffering from cryptosporidiosis.

See full description

Eligible Conditions

  • Cryptosporidiosis
  • HIV Infections

Treatment Effectiveness

Effectiveness Progress

1 of 3

Trial Safety

Safety Progress

1 of 3

Trial Design

0 Treatment Group

This trial involves 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: up to 5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly up to 5 years for reporting.

Closest Location

Romark Laboratories LC - Tampa, FL

Eligibility Criteria

This trial is for patients born any sex of any age. You must have received 1 prior treatment for Cryptosporidiosis or the other condition listed above. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Agree to practice abstinence or use effective methods of birth control (such as a condom) before and during the study.
Have a CD4 count less than or equal to 200 cells/mm3. (Note: Patients with a CD4 count greater than 200 cells/mm3 but who have had cryptosporidiosis for at least 4 weeks may be eligible for this study.)
Test positive for the parasite Cryptosporidium and have severe diarrhea (at least 4 bowel movements per day) for at least 2 weeks.
Are 3 to 65 years old (need consent of parent or guardian if under 18).
Have received treatment for cryptosporidiosis but have become reinfected after treatment.
Have AIDS.

Patient Q&A Section

What are the signs of cryptosporidiosis?

"It used to be believed that waterborne cryptosporidiosis was a rare disease which typically affects children living close to open ground with watercourses. The fact that cryptosporidiosis has a broad geographic distribution means that this is no longer the case. Thus, it is recommended that the medical history should include specific questions about water sources. The mainstay of treatment is oral administration of a nitroimidazole which is absorbed from the intestine. This is especially relevant where water is contaminated by human faeces or other sources." - Anonymous Online Contributor

Unverified Answer

How many people get cryptosporidiosis a year in the United States?

"About 250,000 people in the United States are diagnosed with cryptosporidiosis each year. Children comprise the majority of cases. Cryptosporidiosis is the most common infection for which outpatient care is sought.\n" - Anonymous Online Contributor

Unverified Answer

What causes cryptosporidiosis?

"Cryptosporidial illness often is associated with immunosuppression by HIV disease. The development of Cryptosporidiosis in these patients underscores the need for more research. Additional studies are needed to determine the link between Cryptosporidiopathic Disease and Immunosuppression." - Anonymous Online Contributor

Unverified Answer

What are common treatments for cryptosporidiosis?

"Cryptosporidiosis can be treated by several medications (metronidazole, tinidazole, itraconazole, paromomycin, miltefosine, sulfanilamide, pyrimethamine, and fluconazole). Although some treatments cause serious side effects, the advantages of such treatment (such as short duration of treatment) outweigh the disadvantages." - Anonymous Online Contributor

Unverified Answer

What is cryptosporidiosis?

"Individuals infected with Cryptosporidium are more likely to be infected with other parasite species, most notably intestinal parasites. Cryptosporidiosis, especially as a consequence of cryptosporidiosis immunodeficiency, was suggested to be a risk factor for development of autoimmune disorders and inflammatory bowel diseases, including Crohn's disease and ulcerative colitis." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"Results from a recent paper support a trend over the past fifteen years, in which patients with cryptosporidiosis were being treated more often in combination with other drugs prescribed for malignancies, viral infections, and autoimmune diseases, which suggests a trend toward using newer therapeutic strategies in treating more patients." - Anonymous Online Contributor

Unverified Answer

How serious can cryptosporidiosis be?

"Cryptosporidiosis is a serious diarrhea condition that can have a considerable social impact and be associated with the death of individuals with advanced HIV disease in addition to having an adverse and negative impact on the quality of life of the individuals with this disease (i.e., a severe chronic diarrhea). In addition to the individual's own personal quality of life and the impact on the family, this may translate into high cost of care and inefficient use of diagnostic and therapeutic services if it does not (i.e., the inability to avoid complications related to this waterborne, intestinal parasite infection that can be prolonged). A number of individuals with HIV disease with advanced disease are at a particularly high risk for cryptosporidiosis morbidity." - Anonymous Online Contributor

Unverified Answer

What is the latest research for cryptosporidiosis?

"Cryptosporidiosis is a newly recognized, opportunistic, and potentially serious disease. Cryptosporidiosis is a emerging problem in pediatric and immunocompromised young patients due to the difficulty in diagnosing this disease and the lack of drugs effective in eliminating this disease. To help us to eradicate cryptosporidiosis, there is a need for better understanding of these disease and development of new methods for diagnosis and control of it." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"Symptoms, a diarrhoea grade ≥ 2, and positive blood and otorrhea are risk factors for mortality after treatment for cryptosporidiosis. Results from a recent clinical trial may provide useful guidelines for treatment and follow-up in patients with cryptococcal meningitis or cryptosporidiosis." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of treatment?

"Most common side effects were nausea, vomiting and constipation. Most of them can be expected in any medication. Other common side effects can be more severe but can be avoided by a careful evaluation of all the possible risk factors. Patients must be aware about possible side effects without delay and treatment should be discontinued. There is a lot of information online about side effects of Cryptosporidiosis treatment. There are also few pictures of side effects of Cryptosporidiosis. It is suggested to take some time to look at each photos as they are usually very different from each other. It would be better if you could find your own photos as well on some internet search engine." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets cryptosporidiosis?

"[You could also search for "crypto" in the title of any articles you find, such as this "crypto" time lapse" answer: The incidence of cryptosporidiosis has been decreasing from 7% in the 1960s through 2.3% in the 1990s\nquestion: Is prophylactic antibiotic therapy for patients with febrile neutropenia in chronic granulomatous disease unnecessary? answer: prophylactic antibiotic therapy for patients with febrile neutropenia in chronic granulomatous disease is not necessary." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Cryptosporidiosis by sharing your contact details with the study coordinator.