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Behavioral Intervention

Virtual Reality for Eye Movement Disorders (OCNP Trial)

Led By Kevin E Houston, OD
Research Sponsored by Kevin Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Normal Group: Absence of OCNP or other neurological or neuro-ophthalmic diseases
OCNP Group: Presence of OCNP in one eye with 50% range-of-motion limitation or worse
Must not have
OCNP Group: Range of motion better than 50%
Screening 3 weeks
Treatment Varies
Follow Up 5 minutes
Awards & highlights


"This trial is looking at whether doing eye exercises using virtual reality can improve eye movement in certain conditions."

Who is the study for?
This trial is for individuals with ocular cranial nerve palsies (OCNP) affecting one eye and significantly limiting its movement, or healthy volunteers without OCNP or related conditions. Participants must have decent vision with correction, speak English fluently, and be able to give informed consent. Those with bilateral OCNP, poor visual acuity, significant vision differences between eyes, less affected range of motion, or issues that prevent VR headset use are excluded.Check my eligibility
What is being tested?
The study tests if virtual reality eye exercises can improve the range of motion in patients with abducens palsy and internuclear ophthalmoplegia. It compares exercises done under 'head-cancelled' conditions (where head movements don't affect the VR environment) versus 'head-active' conditions.See study design
What are the potential side effects?
While not explicitly mentioned in the provided information, potential side effects may include discomfort from wearing a VR headset for those sensitive to it and possible temporary disorientation or dizziness due to immersion in virtual reality.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I do not have any brain or eye nerve diseases.
I have OCNP in one eye with at least 50% movement limitation.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
My joint movement is more than half of what is considered normal.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peak saccade amplitude
Secondary outcome measures
Mean head position

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Head CancelledExperimental Treatment1 Intervention
Study tasks performed in head-cancelled conditions
Group II: NormalActive Control1 Intervention
Study tasks performed in normal conditions.

Find a Location

Who is running the clinical trial?

Kevin HoustonLead Sponsor
1 Previous Clinical Trials
11 Total Patients Enrolled
American Academy of OptometryOTHER
4 Previous Clinical Trials
192 Total Patients Enrolled
Kevin E Houston, ODPrincipal InvestigatorUniversity of Massachusetts, Worcester
2 Previous Clinical Trials
201 Total Patients Enrolled
~27 spots leftby Jun 2026