40 Participants Needed

Essential Oils for Healthy Subjects

JH
AZ
Overseen ByAllison Zhang, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Stanford University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Natural Compound A and Natural Compound B in the clinical trial 'Essential Oils for Healthy Subjects'?

Research shows that essential oils, which are similar to Natural Compound A and B, have health benefits like reducing inflammation, boosting the immune system, and improving mood and cognitive performance. These benefits suggest that the treatment might help improve overall well-being in healthy subjects.12345

Are essential oils generally safe for human use?

Essential oils are generally considered safe when used properly, but they can cause toxic reactions if not used correctly. It's important to follow recommended doses and be cautious, especially for children and pregnant women, as they are more vulnerable to potential adverse effects.12678

How do essential oils differ from other treatments for maintaining health?

Essential oils are unique because they are natural plant extracts that can be used in various ways, such as inhalation, massage, or oral intake, to promote health. Unlike many conventional treatments, they offer a wide range of benefits, including antimicrobial, anti-inflammatory, and mood-enhancing effects, and can be used as part of diet supplements or aromatherapy.1291011

What is the purpose of this trial?

The purpose of this study is to explore the positive, holistic health outcomes resulting from regular exposure to naturally occurring compounds predicted to have health benefits. The researchers hope to learn how the human body is influenced by regular exposure to these compounds.

Research Team

MS

Michael Snyder, PhD

Principal Investigator

Stanford University

Eligibility Criteria

This trial is for adults over 18 who can read, speak, and understand English and live in the US. It's not suitable for those who are pregnant or breastfeeding, have epilepsy, mental incapacity, cognitive impairments, or allergies to certain plant families like redwoods and cedars.

Inclusion Criteria

You possess a proficient understanding of the English language.
You are residing in the United States.

Exclusion Criteria

You are currently breastfeeding.
I have epilepsy.
You are allergic to certain types of plants like redwoods, junipers, cypress, cedar, fir, and sequoia.
See 2 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Cycle 1

Participants use diffused 'Natural Compound A' (essential oil) in a diffuser every night when sleeping

4 weeks
Weekly visits for monitoring

Cycle 2

Wash-out period where participants do not use compounds/diffuser

4 weeks
Weekly visits for monitoring

Cycle 3

Participants use diffused 'Natural Compound B' (essential oil) in a diffuser every night when sleeping

4 weeks
Weekly visits for monitoring

Cycle 4

Post-intervention observation period where participants do not use compounds/diffuser

4 weeks
Weekly visits for monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Natural Compound A
  • Natural Compound B
Trial Overview The study tests two natural compounds (essential oils A & B) to see if they promote holistic health benefits through regular exposure. Participants will not know which compound they're receiving as part of the study's design.
Participant Groups
3Treatment groups
Experimental Treatment
Group I: Group C- Natural Compound C to Natural Compound A to Natural Compound BExperimental Treatment3 Interventions
* Cycle 1 (4 weeks): use diffused "Natural Compound C" (control) in a diffuser every night when sleeping * Cycle 2 (4 weeks): will not use compounds/diffuser (wash-out period) * Cycle 3 (4 weeks): use diffused "Natural Compound A" (essential oil) in a diffuser every night when sleeping * Cycle 4 (4 weeks): will not use compounds/diffuser (post-intervention observation period) * Cycle 3 (4 weeks): use diffused "Natural Compound B" (essential oil) in a diffuser every night when sleeping * Cycle 4 (4 weeks): will not use compounds/diffuser (post-intervention observation period) There will be 3 natural compounds; the intervention compounds essential oils and are commercially available and there is a control compound (water). They will be used as intended with diffusers.
Group II: Group B- Natural Compound B to Natural Compound C to Natural Compound AExperimental Treatment3 Interventions
* Cycle 1 (4 weeks): use diffused "Natural Compound B" (essential oil) in a diffuser every night when sleeping * Cycle 2 (4 weeks): will not use compounds/diffuser (wash-out period) * Cycle 3 (4 weeks): use diffused "Natural Compound C" (control) in a diffuser every night when sleeping * Cycle 4 (4 weeks): will not use compounds/diffuser (post-intervention observation period) * Cycle 3 (4 weeks): use diffused "Natural Compound A" (essential oil) in a diffuser every night when sleeping * Cycle 4 (4 weeks): will not use compounds/diffuser (post-intervention observation period) There will be 3 natural compounds; the intervention compounds essential oils and are commercially available and there is a control compound (water). They will be used as intended with diffusers.
Group III: Group A- Natural Compound A to Natural Compound B to Natural Compound CExperimental Treatment3 Interventions
* Cycle 1 (4 weeks): use diffused "Natural Compound A" (essential oil) in a diffuser every night when sleeping * Cycle 2 (4 weeks): will not use compounds/diffuser (wash-out period) * Cycle 3 (4 weeks): use diffused "Natural Compound B" (essential oil) in a diffuser every night when sleeping * Cycle 4 (4 weeks): will not use compounds/diffuser (post-intervention observation period) * Cycle 3 (4 weeks): use diffused "Natural Compound C" (control) in a diffuser every night when sleeping * Cycle 4 (4 weeks): will not use compounds/diffuser (post-intervention observation period) There will be 3 natural compounds; the intervention compounds essential oils and are commercially available and there is a control compound (water). They will be used as intended with diffusers.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials
2,527
Recruited
17,430,000+

Findings from Research

Essential oils (EOs) have a wide range of potential health benefits, including support for digestive health, metabolic regulation, and immune system enhancement, as highlighted by recent clinical trials and preclinical research.
Specific EOs, such as green and black cumin, bergamot, and peppermint, show promise in managing conditions like irritable bowel syndrome, inflammatory bowel disease, and even neuroprotection, suggesting they could be valuable in functional foods and dietary supplements.
Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review.Matera, R., Lucchi, E., Valgimigli, L.[2023]
Essential oils (EOs) have a wide range of therapeutic activities, including anti-inflammatory, antimicrobial, and analgesic effects, which can work both individually and synergistically to promote health.
To ensure the safety and efficacy of EOs, it is crucial to analyze their complex chemical profiles using gas-chromatography-mass detection methods, which helps establish standards for their use.
Essential oils in medicine: principles of therapy.Pisseri, F., Bertoli, A., Pistelli, L.[2008]
Natural essential oil constituents from aromatic herbs and dietary plants have various mechanisms that contribute to cancer prevention and treatment, including antioxidant and antimutagenic properties, immune function enhancement, and modulation of drug resistance.
The review highlights the importance of these constituents' structural categories and their molecular anticancer mechanisms, suggesting their potential as effective chemopreventive agents.
Anticancer activity of essential oils: a review.Bhalla, Y., Gupta, VK., Jaitak, V.[2014]

References

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review. [2023]
Essential oils in medicine: principles of therapy. [2008]
Anticancer activity of essential oils: a review. [2014]
Essential Oils as Multicomponent Mixtures and Their Potential for Human Health and Well-Being. [2023]
[Nursing without and with essential oils: a controlled study of patients in an acute rheumatologic department]. [2019]
A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils. [2006]
Toxicological safety assessment of essential oils used as food supplements to establish safe oral recommended doses. [2022]
[Essential oils: good advice by the pharmacist is necessary]. [2018]
Essential oils: renewal of interest and toxicity. [2022]
[Aromatherapy - From Traditional and Scientific Evidence into Clinical Practice]. [2018]
Influence of Essential Oils on Infectious Agents. [2018]
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