ASL-MRI for Kidney Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a special type of MRI, called Arterial Spin Labeling (ASL), can track changes in kidney cancer before, during, and after treatment. Researchers aim to determine if this imaging can reveal changes in the cancer earlier than standard scans that focus on size. The trial includes several MRI sessions to monitor these changes over time. It suits individuals with advanced kidney cancer who are about to begin specific cancer treatments and can undergo MRI procedures without issues. As an unphased trial, this study provides a unique opportunity to contribute to innovative imaging research that could enhance cancer treatment monitoring.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot be on any other anti-angiogenic agents when you enroll.
What prior data suggests that this MRI technique is safe for kidney cancer patients?
Research has shown that using MRI with ASL (Arterial Spin Labeling) is generally safe for patients. MRI is a common imaging method that uses magnets and radio waves to capture images inside the body. ASL is a special technique that measures blood flow without requiring a contrast dye. Studies indicate that ASL's safety is comparable to that of a regular MRI, meaning there are no additional risks compared to a standard MRI scan.
Previous studies reported no significant adverse events with ASL MRI, suggesting it is well-tolerated. Therefore, for those considering joining this study, the ASL MRI component should be as safe as a typical MRI scan.12345Why are researchers excited about this trial?
Researchers are excited about using ASL-MRI for kidney cancer because it offers a new way to assess blood flow in tumors without the need for contrast agents, which are typically required in standard imaging techniques. Traditional treatments for renal cell carcinoma often rely on surgery, targeted therapy, and immunotherapy, but monitoring their effectiveness can be challenging. ASL-MRI stands out by providing a non-invasive and safer method to evaluate how well these treatments are working. This technique could improve how doctors track tumor progression and tailor treatments more effectively for individual patients.
What evidence suggests that MRI with ASL is effective for kidney cancer?
Research has shown that a special type of MRI called Arterial Spin Labeling (ASL) can detect changes in kidney tumors early during treatment. In this trial, patients with locally advanced or metastatic renal cell carcinoma will undergo ASL MRI to assess its effectiveness. One study found that ASL MRI helped check blood flow in kidney cancer that had spread, indicating how a tumor responded to treatment. Another study demonstrated that using ASL alongside other imaging methods improved the accuracy of tumor assessment. This suggests that ASL MRI might help doctors evaluate treatment effectiveness before the tumor changes in size. While ASL MRI isn't suitable for all types of kidney cancer, it provides important information about tumor blood flow and treatment progress.16789
Are You a Good Fit for This Trial?
This trial is for adults with advanced or spreading kidney cancer who are about to start anti-angiogenic treatment or immunotherapy. They must be able to consent, not pregnant, and have an ECOG status of 0-2 (which measures their level of functioning). People can't join if they're on other anti-angiogenic drugs, pregnant, have MRI-incompatible devices in their body, severe allergies to Gadolinium contrast agents, certain blood disorders or conditions that make lying still for an MRI impossible.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo MRI sessions including Arterial Spin Labeling (ASL) before, during, and after treatment to assess therapy response
Follow-up
Participants are monitored through standard clinical examinations for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- MRI with ASL
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas Southwestern Medical Center
Lead Sponsor