This trial is evaluating whether PF-07284892 will improve 5 primary outcomes and 8 secondary outcomes in patients with Cancer. Measurement will happen over the course of Baseline up to 30 days after last dose of study medication.
This trial requires 211 total participants across 11 different treatment groups
This trial involves 11 different treatments. PF-07284892 is the primary treatment being studied. Participants will be divided into 11 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
Common treatments are used in the treatment of cancer. Common treatments include chemotherapy, hormone therapy, radiation therapy, and hormone therapy combined with chemotherapy. Some cancer treatments, such as surgery and radiotherapy, may also be combined.\n
Current and historical explanations for cancer are confusing and often contradictory. This paper helps to highlight the complexity and interconnection of these issues and suggests a coherent chain of events. There is an urgent need to understand and reverse the cause of virtually all human cancer.
Cancer is a group of diseases that form when normal cells grow and divide in an uncontrolled manner. The most common type of cancer is lung cancer; it is the most frequently diagnosed form of cancer and the second leading cause of death in developed countries.
Nearly 5 million Americans were diagnosed in 2014 with a primary cancer of various types, and nearly 4 million had a recurrence. Among those with recurrent cancer, those with non-small cell lung cancer had the greatest number (n=2.3 million).
Signs of cancer can be divided into clinical signs observable by medical staff and the physical signs which patients experience themselves. Clinical signs include: the signs of pain and inflammation; systemic signs such as sweating, nausea and vomiting; and systemic symptoms which include weight loss, fatigue and anemia. The physical signs which patients experience include: feeling unwell, shortness of breath, dizziness, cough, and a feeling of abdominal pain. There are many types of cancer which present with similar signs and symptoms and therefore the presence of only one sign or symptom is not enough to establish the diagnosis. Many of these signs and symptoms occur with some other disorder which is the reason why they're present more than the cancer.
What do the public think about curing cancer? The public overwhelmingly think that cancer can be cured. The main reason most say otherwise is something people do not know about cancer – cancer is a disease that can spread quickly and is difficult to cure for those who receive treatment. The medical community is trying to do better by educating the public. However, medical advances do advance at a steady pace, and the number of cancer diagnoses will continue to increase. As of now there is not a single cure for all types of cancer. While we are in the phase of discovering how to cure the majority of all solid cancers, there is some progress being made with some aspects of cure which are not yet understood.
The side effects mentioned in this study are similar with that in patients treated with bevacizumab. Adverse effects mainly occurred in the first 3 weeks of treatment. Mild and moderate side effects occurred commonly during the first 6 weeks of treatment and were similar with that in patients treated with bevacizumab. Seizures occurred much less frequently during the initial 6 weeks when comparing to bevacizumab. Patients should make an early diagnosis of adverse effects if possible.
Results from a recent clinical trial suggests that PF-07284892 can be safely and effectively used to improve quality of life when compared with placebo in cancer patients.
The progress of treating cancer is slow and stopping cancer is still a distant hope. New techniques for finding new ways to fight cancer have been made; but most can’t get the resources to apply them. Cancer treatments are being made that should be able to be made available to patients that have already had their cancers. These treatments will help save people lives, and give many, many more more years with their lives. It is all this that is driving me, and millions of others towards becoming happier, healthier and of course - cancer free.
It’s almost 40 years old.\n\nThe disease was discovered by the German surgeon (1735 – 1803). His name is engraved in two places in Paris, one is the Jardin de la Medici, the other the Académie de médecine.\n\nKlaus Patau was a 19th century German physician, and surgeon who was born in Güssing (part of modern-day Zürich, Switzerland). He completed his secondary school education at his hometown, as did his parents. During his tertiary education he studied medicine at the University of Bern (1866–69).
PF07288892 is a small-molecule inhibitor of PI3Kδ selective to the active pool of autophagy and hence its potential as an autophagy-inducing drug warrants further development.
I was diagnosed with cancer in November 2017. My type is an unknown type. What we know is that early detection and an intense chemotherapy regimen is important to get cancer on time, that they do not have cures yet, and they are still alive. \nI had a surgery and chemo therapy the same day, which is the standard of care in my type of cancer. \nI felt like I was running a mile and a yard a second. Now, I'm more like a shadow.\n\nThere are a lot of different types of cancer, and some are deadly and some are not. Some are only detected quickly, while others are in painful stages.