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Treadmill Exercise for Coronavirus

N/A
Waitlist Available
Led By Noah Greenspan, DPT
Research Sponsored by Noah Greenspan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 24-weeks
Awards & highlights

Study Summary

This study is evaluating whether supplemental oxygen may help improve symptoms for individuals who have had carbon monoxide poisoning.

Eligible Conditions
  • Coronavirus
  • Viral Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24-weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24-weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Activity metabolic equivalent of task (MET) tolerated
Blood pressure response to exercise and positional changes
Breathlessness
+5 more
Secondary outcome measures
Depression
Anxiety
Improvement in quality of life
+3 more

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Treadmill Exercise with Supplemental OxygenExperimental Treatment2 Interventions
Participants will receive 24 sessions (2 x week for 12 weeks) of treadmill exercise combined with 6 liters per minute of supplemental oxygen via nasal cannula during exercise and 5-minutes of recovery. The first treadmill session will last 25% longer than the exercise tolerance test, but at a lower intensity, such that 80-100% of peak exercise intensity calculated from the exercise tolerance test MET is achieved within three sessions, after which time and intensity will be increased by no more than 0.5 METS, as tolerated based on symptoms and vitals. Heart rate, rhythm, and oxygen saturation will be continuously monitored, and blood pressure readings will be obtained every three to five minutes.
Group II: Treadmill Exercise with AirPlacebo Group3 Interventions
Participants will receive 8 sessions (2 x week for 4 weeks) of treadmill exercise combined with air delivered via nasal cannula during exercise and 5-minutes of recovery. They will then cross-over to 16 sessions of treadmill exercise combined with 6 liters per minute of supplemental oxygen via nasal cannula during exercise and 5-minutes of recovery. The first treadmill session will last 25% longer than the exercise tolerance test, but at a lower intensity, such that 80-100% of peak exercise intensity calculated from the exercise tolerance test MET is achieved within three sessions, after which time and intensity will be increased by no more than 0.5 METS, as tolerated based on symptoms and vitals. Heart rate, rhythm, and oxygen saturation will be continuously monitored, and blood pressure readings will be obtained every three to five minutes.
Group III: Supplemental Oxygen OnlyPlacebo Group2 Interventions
Participants will receive 8 treatment sessions (2 x week for 4 weeks) of 6 liters per minute of continuous oxygen via nasal cannula for 30 minutes at rest. Heart rate, rhythm, and oxygen saturation will be continuously monitored, and blood pressure readings will be obtained every three minutes. They will then cross-over to 16 sessions of treadmill exercise combined with 6 liters per minute of supplemental oxygen via nasal cannula during exercise and 5-minutes of recovery. The first treadmill session will last 25% longer than the exercise tolerance test, but at a lower intensity, such that 80-100% of peak exercise intensity calculated from the exercise tolerance test MET is achieved within three sessions, after which time and intensity will be increased by no more than 0.5 METS, as tolerated based on symptoms and vitals. Heart rate, rhythm, and oxygen saturation will be continuously monitored, and blood pressure readings will be obtained every three to five minutes.
Group IV: No InterventionPlacebo Group3 Interventions
Participants will receive 8 treatment sessions (2 x week for 4 weeks) of air via nasal cannula for 30 minutes at rest. Heart rate, rhythm, and oxygen saturation will be continuously monitored, and blood pressure readings will be obtained every three minutes. They will then cross-over to 16 sessions of treadmill exercise combined with 6 liters per minute of supplemental oxygen via nasal cannula during exercise and 5-minutes of recovery. The first treadmill session will last 25% longer than the exercise tolerance test, but at a lower intensity, such that 80-100% of peak exercise intensity calculated from the exercise tolerance test MET is achieved within three sessions, after which time and intensity will be increased by no more than 0.5 METS, as tolerated based on symptoms and vitals. Heart rate, rhythm, and oxygen saturation will be continuously monitored, and blood pressure readings will be obtained every three to five minutes.

Find a Location

Who is running the clinical trial?

Noah GreenspanLead Sponsor
University of DaytonOTHER
3 Previous Clinical Trials
148 Total Patients Enrolled
Noah Greenspan, DPTPrincipal Investigator - Pulmonary Wellness Foundation
Pulmonary Wellness Foundation

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Cardiopulmonary Rehabilitation in COVID-19 Longhaulers
Noah Greenspan 2021. "Cardiopulmonary Rehabilitation in COVID-19 Longhaulers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04898205.
~6 spots leftby Apr 2025
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