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Cardiac CT Arm for Coronary Artery Disease (CT-FIRST Trial)

N/A
Waitlist Available
Led By Todd C. Villines, M.D.
Research Sponsored by Walter Reed Army Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months
Awards & highlights

CT-FIRST Trial Summary

In patients with chest pain or shortness of breath who are referred for stress imaging tests (either stress echocardiography or stress nuclear testing), the investigators seek to compare impact of using cardiac CT scans of the heart arteries to the stress test that their doctors ordered.

Eligible Conditions
  • Coronary Artery Disease
  • Stress Test
  • Chest Pain

CT-FIRST Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rates of adverse cardiac events and resource utilization (rates of additional diagnostic tests that are performed for the initial complaint of angina/angina equivalent and clinical outpatient/inpatient/ED encounters for the initial cardiac complaint)
Secondary outcome measures
Avoidance of unnecessary cardiac catheterizations. An unnecessary cardiac catheterization is defined as a catheterization showing non-obstructive coronary disease and no cause for the symptoms.
Change in motivation for healthy behavioral change
Change in subject anxiety, as assessed by the State and Trait Anxiety Inventory
+5 more

CT-FIRST Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cardiac CT ArmExperimental Treatment1 Intervention
Patients referred for stress imaging due to complaints consistent with possible angina, randomized to receive an additional cardiac CT scan.
Group II: No CT ArmActive Control1 Intervention
Patients with symptoms consistent with possible angina, randomized to receive the type of stress imaging test ordered by their physician.

Find a Location

Who is running the clinical trial?

Walter Reed Army Medical CenterLead Sponsor
69 Previous Clinical Trials
20,699 Total Patients Enrolled
Todd C. Villines, M.D.Principal InvestigatorWalter Reed Army Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
CT-FIRST: Cardiac Computed Tomography Versus Stress Imaging For Initial Risk STratification
Todd C. Villines 2007. "CT-FIRST: Cardiac Computed Tomography Versus Stress Imaging For Initial Risk STratification". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01061398.
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~14 spots leftby Apr 2025
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