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CT Angiography for Coronary Heart Disease
N/A
Waitlist Available
Led By Joao AC Lima, MD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the day of procedure
Awards & highlights
Study Summary
This trial is testing whether a low-radiation dose dynamic myocardial CT perfusion is as accurate as a static CTP in detecting coronary artery disease.
Who is the study for?
This trial is for people with severe chest pain despite treatment, who have documented coronary artery disease and can sign consent. They must be able to undergo angiography or CT angiography. Exclusions include allergies to iodine contrast media, kidney issues, certain heart conditions like uncontrolled arrhythmias or severe heart failure, recent heart surgeries or interventions, high radiation exposure history, and intolerance to specific medications.Check my eligibility
What is being tested?
The study tests the safety and accuracy of low-radiation dynamic myocardial CT perfusion imaging versus static CTP in detecting significant coronary artery disease. Dynamic CTP involves serial imaging over time to measure blood flow changes using advanced scanners that reduce radiation dose.See study design
What are the potential side effects?
Potential side effects may include allergic reactions to the contrast dye used during imaging (for those not already excluded due to known allergies), kidney function impairment from the dye (excluded if pre-existing condition), and exposure to a low level of radiation.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 1-4 hours after initiation of test interpretation
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1-4 hours after initiation of test interpretation
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Incidence of treatment-emergent adverse events (Safety and tolerability)
Secondary outcome measures
Duration of exam (hours)
Frequency of interpretable images
Frequency of interpretable myocardial segments
+8 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Interventional GroupExperimental Treatment1 Intervention
Participants undergoing dynamic computed tomography myocardial perfusion imaging.
Intervention: Diagnostic Test: Dynamic Computed Tomography Angiography Imaging
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Computed Tomography Angiography
2013
N/A
~440
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Who is running the clinical trial?
Johns Hopkins UniversityLead Sponsor
2,269 Previous Clinical Trials
14,838,642 Total Patients Enrolled
27 Trials studying Coronary Artery Disease
56,579 Patients Enrolled for Coronary Artery Disease
Toshiba Medical Systems Corporation, JapanIndustry Sponsor
1 Previous Clinical Trials
59 Total Patients Enrolled
1 Trials studying Coronary Artery Disease
59 Patients Enrolled for Coronary Artery Disease
Joao AC Lima, MDPrincipal InvestigatorJohns Hopkins School of Medicine
1 Previous Clinical Trials
50 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My kidney function is reduced, with high creatinine or low clearance.I have severe heart failure or a serious heart valve problem.I have an irregular heartbeat or a severe heart block.You have a certain type of heart device called an implantable cardioverter-defibrillator that is within the area where the imaging will be done.I have had multiple myeloma or an organ transplant.I was hospitalized for unstable chest pain but have been stable for the last 48 hours.You are allergic to iodine-based contrast dye.I have had kidney issues after a dye was used for imaging tests.You have had a lot of radiation exposure from medical scans in the past 18 months.I have had heart surgery in the past.I have had a procedure to open my heart's arteries within the last 6 months.I've had severe chest pain or heart attack symptoms in the last 2 days.I have severe chest pain during normal activities despite treatment.If you need a special heart test called invasive coronary angiography or CT angiography, you cannot participate.You cannot participate if you have very low blood pressure, recently used certain medications, recently had a heart attack, have a very slow heart rate, or have a body mass index over 30.I have stable chest pain from heart disease and have been on treatment for it for at least a month.You have been diagnosed with coronary artery disease using a special type of heart imaging test.I am allergic to beta-blockers or have severe asthma or COPD.
Research Study Groups:
This trial has the following groups:- Group 1: Interventional Group
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is recruitment open to participants below the age of eighty?
"To qualify for this medical trial, individuals must be aged between 45 and 85. There are 50 clinical trials available to those under 18 years old and 875 options for people over the age of 65."
Answered by AI
What criteria do individuals need to satisfy in order to join the trial?
"Eligible applicants for this coronary artery disease clinical trial should be aged between 45 and 85, with about 10 patients needed."
Answered by AI
Is enrollment for this research study still open?
"Unfortunately, this healthcare trial is not presently in need of participants. This medical study was originally posted on March 30th 2018 and last updated on January 10th 2022. But luckily, there are still 910 other trials actively looking for patients at present."
Answered by AI
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