This trial is evaluating whether Vaginal Stent will improve 2 primary outcomes and 2 secondary outcomes in patients with Constriction, Pathologic. Measurement will happen over the course of 24 hours - 4 weeks from stent placement.
This trial requires 40 total participants across 4 different treatment groups
This trial involves 4 different treatments. Vaginal Stent is the primary treatment being studied. Participants will be divided into 4 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
The histopathologic findings for constriction, pathologic suggest that constriction is not a benign condition and consequently, there is a need for a surgical cure and for a medical treatment. The surgeon should treat constriction using local anesthesia and close follow-up of the patient. Constriction, pathologic may require a procedure to relieve the pressure and is probably justified in cases of acute decompression. In addition, the surgeon should take precaution whenever possible and avoid any unnecessary operations.
About 4% (913,990 persons) of men and 15% (1,931,060 persons) of women die of constriction, pathologic. These estimates are somewhat higher than those for all causes of death and suggest that constriction, pathologic is not a negligible cause of death. Deaths caused by constriction, pathologic may make contributions to the rates of suicide, accidental injury, and the overall mortality that would be expected if deaths caused by suicide and accidental deaths were excluded.
There is often a constricting lesion arising from a subepithelial space on the surface of an internal organ. The space is lined with mesenchyma. An intact capsule from a benign lesion of the same shape as the original lesion may be seen. If the lesion is not benign, it is often the first of a series of adenomas or carcinoma of the same shape and location. In those cases where the original lesion is not benign, it is often at a different site, and the capsule of the benign lesion surrounds the lesion in a way different from that of the original lesion.
Atherosclerotic lesions in the aorta involve intimal thickening caused by vasodilatation of the vessel wall. The lesions form as a result of the accumulation of collagen around the vessel lumen.
This is the first study to describe treatments for constriction, pathologic onlay/sublay, and anastomotic fistulae. Most people undergoing treatment were treated with constricted closure or no closure.
Constriction, pathologic, or the constriction-pathologic syndrome, is a broad array of medical problems spanning every anatomical and functional organ, and even specific symptoms and signs can be in and of themselves a diagnosis of constriction. As a pathophysiologic basis, it emphasizes the presence of physiological disturbances in all tissue layers which can influence the mechanics and elasticity of tissue. The constellation of symptoms and their relationship to specific bodily processes was outlined by Wiggers.
The use of vaginal stents is often advocated in the last decade. However, the indications for this procedure are not always justified. We found the following guidelines in the literature: 1. Patients with vaginal obstruction should have surgery; 2. Patients with intrauterine adhesions should have surgery, especially in case of severe prolapse, or stents should be placed in patients with large fistulas, or 3. Women with anorectal fistulas will do well if adequate stenting is used.
Vaginal stents have been widely used since the 1990s as an alternative mode of treatment for pathological conditions of the vagina. In spite of the wide body of literature on these devices and reports on their clinical applicability, vaginal stents have not gained widespread acceptance and their usage is constrained. This article provides a comprehensive review of available literature on vaginal stents and their clinical applicability. It also offers up-to-date reviews related to vaginal stents from an evidence-based perspective to guide women in selecting the best clinical applicability.
The use of vaginal stents in women with stress urinary incontinence is safe. More people prefer stent to conservative therapy. However, the high risk of stent migration warrants further study and caution with regard to stent removal, particularly if symptoms improves with stent removal.
When constriction causes severe discomfort, severe physical limitations such as pain, edema, and reduced functional abilities are common; however, constriction without significant discomfort is more likely to be overlooked even by experienced physicians.
The average age a patient is diagnosed with constriction, pathologic in South Korea is 71-years-old. It is a little bit older than the average age when patients begin to have constriction, pathologic. The reason for this phenomenon is probably because more women are diagnosed with constriction, pathologic as they are more often diagnosed with this disease. This phenomenon seems to be more common in the female sex.
A small number of new research studies have been published since the last review. The largest body of study was published two years ago by Cordero et al. from the Mayo Clinic in Minnesota: The authors examined the utility of MRI and CSF-based biomarkers to assist clinical diagnosis of constrictive pericarditis. While some findings from previously published studies were reproduced, the authors found there was insufficient evidence from any of the published studies to recommend clinical utility of biomarkers. The authors conclude that the role of biomarkers in clinical diagnosis of constrictive pericarditis is not robust or reliable enough to advise clinical decision making based on the available evidence.