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Behavioral Intervention

Participants With Obsessive-compulsive Disorder (OCD) for Obsessive-Compulsive Disorder

N/A
Waitlist Available
Led By Rachel Marsh, Ph.D.
Research Sponsored by New York State Psychiatric Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up single time point (baseline)
Awards & highlights

Study Summary

This trial looks at how well exposure and response prevention therapy works in treating OCD in children and adolescents.

Eligible Conditions
  • Obsessive-Compulsive Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~single time point: baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and single time point: baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brain Activation Associated With the Resolution of Cognitive Conflict
Secondary outcome measures
Brain Gray Matter Thickness
Functional Connectivity
Structural Connectivity (Streamline Counts)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Participants With Obsessive-compulsive Disorder (OCD)Experimental Treatment1 Intervention
Children and adolescents who meet DSM-IV diagnostic criteria for OCD and had clinically significant obsessive-compulsive symptoms (CY-BOCS score>15). Comorbid anxiety disorders, but no other lifetime psychiatric diagnoses, were permitted in the OCD group as long as OCD was the primary diagnosis. Participants were unmedicated and had not received a full course of CBT with exposure and response prevention for OCD prior to their participation in the study. Following baseline assessment and scan, patients with OCD underwent a course of manualized treatment of CBT with E/RP adapted for pediatric OCD delivered by a licensed clinical psychologist or advanced supervised graduate student in clinical psychology at the NYSPI.
Group II: Healthy Control (HC) ParticipantsActive Control1 Intervention
Healthy control (HC) participants matched on age and sex with the OCD group. HC participants had no lifetime psychiatric disorders. HC participants were assessed and scanned at baseline and again after 12-16 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CBT treatment for OCD based on Exposure & Response Prevention (EX/RP) and when indicated medication treatment
2014
N/A
~60

Find a Location

Who is running the clinical trial?

New York State Psychiatric InstituteLead Sponsor
475 Previous Clinical Trials
153,852 Total Patients Enrolled
24 Trials studying Obsessive-Compulsive Disorder
892 Patients Enrolled for Obsessive-Compulsive Disorder
National Institute of Mental Health (NIMH)NIH
2,784 Previous Clinical Trials
2,689,222 Total Patients Enrolled
65 Trials studying Obsessive-Compulsive Disorder
13,926 Patients Enrolled for Obsessive-Compulsive Disorder
Rachel Marsh, Ph.D.Principal InvestigatorNew York Psychiatric Institute

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Depression and AnxietyJournal
Subcortical Shape in Pediatric and Adult Obsessive‐compulsive Disorder
Wang, Zhishun, Martine Fontaine, Marilyn Cyr, Moira A. Rynn, Helen Blair Simpson, Rachel Marsh, and David Pagliaccio. 2022. “Subcortical Shape in Pediatric and Adult Obsessive‐compulsive Disorder”. Depression and Anxiety. Wiley. doi:10.1002/da.23261.
clinicaltrials.govStudy
Overlapping Neural Circuits in Pediatric OCD
Rachel Marsh 2014. "Overlapping Neural Circuits in Pediatric OCD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02421315.
~5 spots leftby Apr 2025
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