CLINICAL TRIAL

e-CBT for Obsessive-Compulsive Disorder

Recruiting · 18+ · All Sexes · Kingston, Canada

This study is evaluating whether an online cognitive behavioral therapy program can reduce brain activation levels in people with obsessive compulsive disorder.

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About the trial for Obsessive-Compulsive Disorder

Eligible Conditions
Compulsive Personality Disorder · Obsessive-Compulsive Disorder

Treatment Groups

This trial involves 2 different treatments. E-CBT is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
e-CBT
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
The reseacher diagnosed the individual with OCD by using the DSM-5. show original
Competence to consent to participate
is an advantage Being able to speak English fluently is an advantage in the job market show original
Consistent and reliable access to the internet
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Week 1, Week 8, Week 16, 6 months
Screening: ~3 weeks
Treatment: Varies
Reporting: Week 1, Week 8, Week 16, 6 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Week 1, Week 8, Week 16, 6 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether e-CBT will improve 5 primary outcomes in patients with Obsessive-Compulsive Disorder. Measurement will happen over the course of Week 1, Week 16.

Changes in Brain Structure and Activation: Functional Magnetic Resonance Imaging (fMRI)
WEEK 1, WEEK 16
fMRI will be administered to observe any changes in structure.
WEEK 1, WEEK 16
Changes in Quality of Life: Quality of Life and Enjoyment Questionnaire (Q-LES-Q)
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
Q-LES-Q will be administered to analyze changes in quality of life from treatment. Scale of 0-5 for each question with 0 being not at all and 5 being frequently
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
Changes in symptoms: Obsessive-Compulsive Inventory - Revised (OCI-R)
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
OCI-R will be administered to analyze changes in symptoms from treatment. Scale of 0-4 with 0 being not at all and 4 being extreme severity.
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
Changes in symptoms: Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
Y-BOCS will be administered to analyze changes in symptoms from treatment. Scale of 0-4 for each question with 0 being no symptom severity and 4 being high symptom severity
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
Changes in level of functioning: Sheehan Disability Scale (SDS0
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS
SDS will be administered to analyze changes in levels of functioning. Scale of 0-10, 10 being the worst.
WEEK 1, WEEK 8, WEEK 16, 6 MONTHS

Who is running the study

Principal Investigator
C. S.
Callum Stephenson, Principle Investigator, MSc Candidate
Queen's University

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can obsessive-compulsive disorder be cured?

Results from a recent clinical trial provides preliminary evidence (as of the start of publication) that OC and OCB patients can improve. However, it remains unproven whether OC patients were responding only to cognitive behavioural therapy and other'standard of care' medications in all cases. Thus further prospective investigations are needed to address the issue of "response bias" or'response bias in the placebo and treatment control groups'.

Anonymous Patient Answer

What are the signs of obsessive-compulsive disorder?

Symptoms and diagnoses of OCD include obsessions and compulsions, which can lead to significant anxiety. People may not recognise symptoms of OCD and may avoid or forget the symptoms. theme: brain question: Do frontal lobe lesions induce specific impairments in the retrieval of verbal episodic information? answer: The present findings suggest that frontal lobe lesions may cause memory dysfunction by disrupting processes for the retrieval of verbal episodic information from a semantic buffer.

Anonymous Patient Answer

What causes obsessive-compulsive disorder?

The presence of a personal or family history of OCD does not predispose to a later development of OCD. Further studies are needed to pinpoint the exact factors which account for susceptibility to OCD.

Anonymous Patient Answer

What are common treatments for obsessive-compulsive disorder?

Treatment in the first year depends on the individual and is based on symptoms, duration, and type of exposure. The first line is mostly pharmacotherapy for anxiety and depressive symptoms and second line is primarily cognitive and behavioural therapies for OCD. Second line treatment is ineffective. In more severe cases some of those affected go back to more typical pharmacotherapy, first line in more recent years, but also with relatively limited efficacy. The first line for OCD is typically either pharmacotherapy or CBT that are most effective. CBT for OCD is typically the least used, with a fairly limited and inconsistent effect. Pharmacotherapy has a modest effect on OCD. Antidepressant treatment is less effective for depression in OCD than for those with major depression alone.

Anonymous Patient Answer

How many people get obsessive-compulsive disorder a year in the United States?

There are more than 4.8 million new diagnoses of OCD annually from a population of approximately 300 million. The American Psychiatric Association and the CDC are encouraging increased public awareness of OCD, particularly by using a series of animated cartoon characters as an advertising tool.

Anonymous Patient Answer

What is obsessive-compulsive disorder?

Obsessive-compulsive disorder can be seen in all races/ethnic groups and all genders. There may be more variability in its presentation, course, and treatment among the different races/ethnicities.

Anonymous Patient Answer

How serious can obsessive-compulsive disorder be?

While OCD can be dangerous when not properly treated, it is a benign disorder with minimal effects. We recommend that OCD be diagnosed and treated when appropriate to prevent progression to serious medical problems.

Anonymous Patient Answer

What is e-cbt?

E-CBT is an effective and well-tolerated intervention for pediatric OCD in preschool children. E-CBT may be used to assist children with OCD get access to a treatment model that focuses on reinforcement learning theory.

Anonymous Patient Answer

Who should consider clinical trials for obsessive-compulsive disorder?

There are no medical reasons why someone with OCD would be considered for clinical trial. However, OCD is very difficult to treat by itself, and clinical trials can help researchers evaluate new treatments for this condition.

Anonymous Patient Answer

Does obsessive-compulsive disorder run in families?

Although some researchers found no evidence that the disease was inherited, we suggest that it is possible that an increase in the prevalence of the disease between generations in many cases is simply because of an increased exposure to the disorder.

Anonymous Patient Answer

Is e-cbt typically used in combination with any other treatments?

E-cbt used as a standalone therapy in OCD patients typically does not improve significantly on clinical measures of outcome compared to any other medication, and may even be worse than placebo in OCD patients.

Anonymous Patient Answer

Is e-cbt safe for people?

There are few studies to date, and our study was specifically conducted to give evidence of cbt's safety. The findings suggest cbt is not harmful when used appropriately over at least 3 months. The findings suggest cbt can be a legitimate tool in the management of OCD and that further research and guidelines should be developed.

Anonymous Patient Answer
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