This trial is evaluating whether KCI AbThera will improve 1 primary outcome and 2 secondary outcomes in patients with Hypertension. Measurement will happen over the course of admission to hospital discharge; expected average of hospital stay 4 weeks..
This trial requires 50 total participants across 2 different treatment groups
This trial involves 2 different treatments. KCI AbThera is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"There was a large variation in the prevalence of IAH among the states. These states ranged from low and moderate to high rates of IAH. One can find the incidence of IAH in each state by using Population Health Facts. To get specific numbers, one can use the table in the Population Health Facts. The most common causes of IAH were hypertension and intra-abdominal trauma. In this article, as IAH occurs mainly through hypertension, treatment of hypertension is a potential management of IAH." - Anonymous Online Contributor
"IAP is not always treated. In most cases, the goal of treatment is not to cure IAH, but rather to decrease further harm to the patient. Although conservative treatment often is the treatment of choice, the role of surgery as a treatment option is an important aspect. Further research is needed to understand the role of surgery as a treatment option." - Anonymous Online Contributor
"IAH is associated with increased mortality and short- and long-term morbidity due to increased catecholamine production and vasodilation, respectively. IAH is prevalent in critical patients in intensive care unit despite high hemodynamic and ventilation support or in patients without shock." - Anonymous Online Contributor
"It is difficult to determine whether intra-abdominal hypertension is not only relieved by decreasing intra-abdominal pressure, but also by reducing fluid resuscitation or by increasing blood pressure." - Anonymous Online Contributor
"IAH is a multifactorial condition where gastrointestinal motility, local perfusion and compliance effects with the intra-abdominal compartment play a substantial role. IAH can be attributed to many different causes e.g. intra-abdominal infections or mal-absorption with consequent mal-distribution of plasma volume (hypoperfusion)." - Anonymous Online Contributor
"The symptoms of severe intra-abdominal hypertension involve abdominal pain, vomiting and nausea and hypotension. Intra-abdominal hypertension may also result in acute kidney injury. The combination of the criteria of the ACCP/SCCM/RSST Intravenous Guidelines may also be clinically useful for the diagnosis of severe intra-abdominal hypertension." - Anonymous Online Contributor
"IAH is an important factor associated with morbidity and mortality in trauma patients. This information may help us plan protocols for management and prevent adverse consequences of IAH in trauma patients." - Anonymous Online Contributor
"The use of Kci AB in high risk patients with intra-abdominal hypertension can be beneficial after appropriate risk analysis. Further prospective, randomized studies are needed to establish its role as a complementary therapy to conventional treatments." - Anonymous Online Contributor
"Symptom scores were improved at 24 weeks, with no change in functional scores, in kci-treated patients when compared with baseline. No serious side effects were noted with kci treatment." - Anonymous Online Contributor
"This was the first clinical trial on abciximab. There were several other clinical trials involving abciximab using different dosing and injection routes, in combination with aspirin and with or without thrombolytic therapy." - Anonymous Online Contributor
"Kci ABThera is not associated with abdominal pain when given for the treatment of postmenopausal women who are not pregnant or have had no prior history of gastrointestinal or perianal pain." - Anonymous Online Contributor
"Patients with IAH on average are aged around 70 years, making them on average, the second oldest with IAH (only behind the elderly) in the world. While this population has an approximate 2:1 risk of mortality from other causes, mortality from IAAH is exceedingly rare compared to IAH from other causes." - Anonymous Online Contributor