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TST for Latent Tuberculosis Infection (LTBI Trial)

N/A
Waitlist Available
Led By James Mancuso, MD MPH
Research Sponsored by Uniformed Services University of the Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Any recruit, age 18 years or older, undergoing routine entry-level medical processing at Fort Jackson
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 48-72 hours
Awards & highlights

LTBI Trial Summary

This trial will test a targeted approach to screening for latent tuberculosis infection (LTBI) using interferon-gamma release assays (IGRA) in military recruits. The current policy of universal application of the Mantoux tuberculin skin test (TST) to screen for LTBI may result in many TST reactions among recruits who are at low risk for LTBI. The trial's hypotheses are that the targeted testing will reduce unnecessary testing of low-risk recruits without affecting the identification of higher-risk recruits, and that many discordant results between the TST and IGRA may be explained by cross-reactivity to non-t

Eligible Conditions
  • Latent Tuberculosis Infection

LTBI Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

LTBI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48-72 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48-72 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
TST Induration Will be Interpreted Relative to Risk, in Accordance With Published CDC Guidelines.
Secondary outcome measures
Positive QFT-GIT Result
Other outcome measures
Battey Skin Test Result
T-Spot Result
TST Results for the Population for Which All 4 Tests Have Valid Results and no Borderline Results

LTBI Trial Design

1Treatment groups
Experimental Treatment
Group I: All study participantsExperimental Treatment4 Interventions
Subjects administered the TB skin test, Battey skin test, QFT-GIT, and T-Spot
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
BST
2009
N/A
~2020
TST
2009
N/A
~2020

Find a Location

Who is running the clinical trial?

Uniformed Services University of the Health SciencesLead Sponsor
116 Previous Clinical Trials
89,399 Total Patients Enrolled
Henry M. Jackson Foundation for the Advancement of Military MedicineLead Sponsor
92 Previous Clinical Trials
90,575 Total Patients Enrolled
Infectious Diseases Clinical Research ProgramOTHER
8 Previous Clinical Trials
2,024 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
South Carolina
How old are they?
18 - 65
What site did they apply to?
Fort Jackson, SC
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits
James Mancuso 2009. "Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00804713.
~125 spots leftby Apr 2025
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