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Fructose Uptake by Colorectal Cancer

N/A

Recruiting

Led By Alessio Pigazzi, MD,PhD

Research Sponsored by Weill Medical College of Cornell University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal)

Awards & highlights

Study Summary

This trial is designed to study how human colorectal tumors absorb fructose. Subjects with colorectal cancer will drink a solution containing fructose or xylose, and then have surgery to remove the tumor. The trial will compare how much fructose and xylose the tumor absorbed with how much was absorbed by normal tissue. The hypothesis is that tumors will absorb more fructose than xylose.

Who is the study for?

This trial is for adults with non-hereditary invasive colonic adenocarcinoma who are set to have surgery. They must understand English and give informed consent. It's not for those on steroids, with inflammatory bowel disease, uncontrolled diabetes (A1C >7.0), or current infections.Check my eligibility

What is being tested?

The study tests how colorectal tumors absorb sugars by giving patients a sugar solution before surgery. Researchers will compare the uptake of fructose versus xylose in tumor tissues against normal tissues and liver to see if cancer directly absorbs these sugars.See study design

What are the potential side effects?

Since this trial involves consuming a sugar solution, side effects may be minimal but could include potential blood sugar spikes or digestive discomfort, especially relevant for individuals excluded due to conditions like uncontrolled diabetes.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal)

This trial's timeline: 3 weeks for screening, Varies for treatment, and morning after the consumption of oral sugar solutions(during surgery at the time of specimen removal) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

The abundance of fructose in tumor extracts

Secondary outcome measures

Abundance of Fructose and [13C]-Fructose in the intestine

Abundance of Fructose and [13C]-Fructose in the liver

Abundance of Fructose and [13C]-Fructose in the mesentery tissues

+8 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: Cohort 2: D-Xylose (xylose-fed)Experimental Treatment1 Intervention

On the day of Surgery, between two and three hours before surgery. Subjects will prepare the sugar solutions (Xylose-containing solution: 250 mL of water containing 41.25 g of D-Xylose and 33.75g of D-Glucose) by adding 250 ml water to the sugar powder provided by the study team and drink it betweentwo and three hours before surgery. Subjects will be reminded the day before the surgery to drink the solution.

Group II: Cohort 1: HFCS (fructose-fed)Experimental Treatment1 Intervention

On the day of Surgery, between two and three hours before surgery. Subjects will prepare the sugar solutions (Fructose-containing solution: 250 mL of water containing 41.25 g of D-Fructose and 33.75 g of D-Glucose) by adding 250 ml water to the sugar powder provided by the study team and drink it between two and three hours before surgery. Subjects will be reminded the day before the surgery to drink the solution.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor

1,054 Previous Clinical Trials

1,316,516 Total Patients Enrolled

Alessio Pigazzi, MD,PhDPrincipal InvestigatorWeill Medical College of Cornell University

1 Previous Clinical Trials

20 Total Patients Enrolled

Media Library

Fructose Uptake by Primary Human Colorectal Tumors (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05136092 — N/A

Colorectal Tumor Research Study Groups: Cohort 1: HFCS (fructose-fed), Cohort 2: D-Xylose (xylose-fed)

Colorectal Tumor Clinical Trial 2023: Fructose Uptake by Primary Human Colorectal Tumors Highlights & Side Effects. Trial Name: NCT05136092 — N/A

Fructose Uptake by Primary Human Colorectal Tumors (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05136092 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available openings in this research program for participants?

"According to clinicaltrials.gov, this investigation is currently recruiting patients and was initially published on February 16th 2022 with the most recent update taking place a week later on February 23rd."

Answered by AI

What is the aggregate number of participants in this clinical investigation?

"Affirmative. Clinicaltrials.gov reveals that the trial, which was initially posted on February 16th 2022 and last modified a week later, is actively seeking out enrollees at 1 medical site with 12 participants in total being sought after."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Pilot Study to Determine Fructose Uptake by Primary Human Colorectal Tumors

2022. "A Pilot Study to Determine Fructose Uptake by Primary Human Colorectal Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05136092.