CLINICAL TRIAL

Therasphere Therapy for Colorectal Cancer

Locally Advanced
Metastatic
Waitlist Available · 18+ · All Sexes · Baltimore, MD

This study is evaluating whether a pre-therapy scan can predict the amount of radiation to the liver from a therapy.

See full description

About the trial for Colorectal Cancer

Eligible Conditions
Metastatic Colorectal Cancer (CRC) · Colorectal Neoplasms · Colorectal Carcinoma (CRC)

Treatment Groups

This trial involves 2 different treatments. Therasphere Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Therasphere Therapy
OTHER
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
A patient with a performance status score of 0 to 2 is considered to have a mild functional impairment show original
The person can understand and agree to what is happening in the medical procedure they are consenting to show original
4 weeks ago, the person had radiation, surgery, or chemotherapy. show original
Patient is willing to participate in the study and has signed the study informed consent
Liver metastases are unresectable
The cancer has spread to the liver and is now considered a metastatic cancer show original
(stage IV) have a median survival of 12 months show original
Some tumors look more vascular than others, based on estimates made by the investigator show original
Age ≥18 years
This means that a patient has a life expectancy of three months or more. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Pre-Treatment and up to 6 hours Post-Treatment
Screening: ~3 weeks
Treatment: Varies
Reporting: Pre-Treatment and up to 6 hours Post-Treatment
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Pre-Treatment and up to 6 hours Post-Treatment.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Therasphere Therapy will improve 1 primary outcome in patients with Colorectal Cancer. Measurement will happen over the course of Pre-Treatment and up to 6 hours Post-Treatment.

Change in dose estimate of Therasphere treatment to liver target tumor
PRE-TREATMENT AND UP TO 6 HOURS POST-TREATMENT
Change in dose estimates of radioactivity from Therasphere treatment to liver tumor target, measured in Gray, will be compared at pre-treatment and up to 6 hours post-treatment.
PRE-TREATMENT AND UP TO 6 HOURS POST-TREATMENT

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for colorectal cancer?

For most people it involves either surgical resection with a curative intent or surgical adjuvants to reduce malignancy. For some others, it is a palliative operation with curative intent. Some of them maybe candidates for adjuvant treatment. For a few others curative treatment with curative intent is possible.

Anonymous Patient Answer

What causes colorectal cancer?

This is a very broad topic. A major change at the level of the individual leads to the development of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer). I haven’t covered everything, but the information will help make the link more clearer. The most common cause is intestinal cancer. There is no single disease; a colon cancer is invariably formed from many types of colon cancer.

Anonymous Patient Answer

What are the signs of colorectal cancer?

Patients should be asked what motivates them to seek medical help. Patients who present with signs of anemia, and for whom colonoscopies are scheduled, should be counseled on how to avoid bleeding with NSAIDs prior to colonoscopy, or if they cannot afford this, they may need to take a low dose aspirin to minimize the use of NSAIDs. Patients with signs of abdominal pain, diarrhea, constipation, weight loss or change in stools should be counseled that a colonoscopy is probably required for cancer. Cancer can be diagnosed at any age, but early screening should be encouraged for individuals who are at high risk for these cancers. summary: In a recent study, findings focuses on the signs of colorectal cancer.

Anonymous Patient Answer

Can colorectal cancer be cured?

This model suggests that an earlier diagnosis of [colorectal cancer](https://www.withpower.com/clinical-trials/colorectal-cancer) may be accompanied by a greater survival rate and a lower rate of death from cancer than in those diagnosed more recently. The earlier the treatment and the less radical the surgical removal of the tumor, the higher the survival rate, the better the prognosis.

Anonymous Patient Answer

What is colorectal cancer?

Colorectal Cancer is a cancer that begins in the colon or rectum and that typically occurs in men over the age of 50. Treatment is usually with surgery.

Anonymous Patient Answer

How many people get colorectal cancer a year in the United States?

The number of new CRC cases is about 2.8 cases per 100,000 people/year. This means there is about one new CRC case per 200 people per year. The incidence rate is 0.55 new CRCs per 100,000 people/year. We expect about 0.6 new CRC cases a year per 100,000 people. We expect about 50,000 new CRC cases annually in the United States with approximately 200 new CRCs for every 100,000 people. We expect more CRCs from the age of 70 and more from the age of 80. The age-adjusted CRC incidence rate for the entire country was 0.52 new CRCs per 100,000 people/year. Our age-adjusted lifetime risk is 0.

Anonymous Patient Answer

Have there been other clinical trials involving therasphere therapy?

Only 7 clinical trials involving therasphere were published to date. Further research is needed to determine the safety and usefulness of therasphere cancer therapy, and a standardized, standardized methodology in a clinical trial is needed that allows a broader range of results. For this reason, the therasphere therapy paradigm should be considered as a potential non-chemical adjunct to standard methods for the treatment of colon cancer.

Anonymous Patient Answer

What does therasphere therapy usually treat?

Therapists have been practicing for a very long time to provide this type of therapy to patients. It will, however, be difficult to determine if and the extent to which their therapy is actually effective as well as the efficacy of the treatment. The first question that patients ask themselves is why they are receiving this specific type of therapy, and that is what I argue is the proper question for research. The second, of course, is whether Therasphere therapy is truly a proper, and appropriate, method of treatment. It may possibly be, and it may not. It's definitely worth asking and looking into further. But, hopefully, research will one day be able to provide a definitive answer.

Anonymous Patient Answer

Does therasphere therapy improve quality of life for those with colorectal cancer?

Theraspheres are very effective in patients with colon cancers and have the potential to improve the patients' quality of life. The effects reported by patients were not explained by changes in tumor size.

Anonymous Patient Answer

How quickly does colorectal cancer spread?

The histological subtype of colorectal cancer (determined by biopsy) did not differ in the rate and extent of tumor spread; however, an increasing rate of metastatic spread in the synchronous tumors was observed. Tumors found in distant lymph nodes may represent a subset of primary tumors known as stage IV disease. These data support two key points: (1) in the absence of imaging findings or metastases, the TNM classification should be based solely on biopsy findings and (2) the AJCC/UICC staging system was found to be the best staging system for colorectal carcinoma.

Anonymous Patient Answer

Does colorectal cancer run in families?

There are family clustering patterns of colon and/or rectal cancer but these patterns do not provide evidence for a familial susceptibility. The data strongly suggest that environmental risk factors are the primary determinants of colorectal cancer risk.

Anonymous Patient Answer

What is the survival rate for colorectal cancer?

Almost all of the colorectal cancer patients in our centers survived for a very long time. There were hardly any differences between different age brackets except for patients being less than 40 years, they had longer lengths of survival compared to their more elderly counterparts.

Anonymous Patient Answer
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