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Outdoor vs Indoor Walking for Aging and Cognitive Health (SAGE Trial)
N/A
Waitlist Available
Led By Teresa Liu-Ambrose, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 12 weeks and 6 months
Awards & highlights
SAGE Trial Summary
This trialwill measure if outdoor walks can improve cognitive function, motor function, emotional well-being, health-related behaviors and quality of life in older adults with mild cognitive impairment better than indoor walking.
Who is the study for?
This trial is for older adults aged 65-80 living in the Greater Vancouver area, who can function daily without significant impairment and have mild cognitive issues but no dementia. They must be able to walk, start an exercise program, live independently, and not be on certain medications or involved in other cognitive trials.Check my eligibility
What is being tested?
The SAGE trial is testing whether walking outdoors has better effects on brain health compared to walking indoors for those with mild cognitive impairment. Participants will follow a structured walking program three times a week for 12 weeks and will be checked again after three months.See study design
What are the potential side effects?
While aerobic exercise like walking is generally safe, potential side effects may include muscle soreness, fatigue, falls or injuries especially if participants have pre-existing conditions that affect their mobility or balance.
SAGE Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline to 12 weeks and 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 12 weeks and 6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Digits Span Forwards and Backwards
Change in List Sorting Performance
Secondary outcome measures
5-level EuroQoL 5-dimension (EQ-5D-5L) questionnaire
Change in Blood Pressure
Change in Centre for Epidemiological Studies Depression Scale
+15 moreSAGE Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic Exercise OutdoorsExperimental Treatment1 Intervention
Each session will consist of 10 min of warm-up, 40 min of aerobic exercise, and 10 min of cool-down. Aerobic exercise will be progressive and of moderate intensity. During training, each participant will wear a heart rate monitor and will be asked to work initially at approximately 45% of his/her target heart rate (i.e., heart rate reserve (HRR)) and gradually progress to reach the target of 70% of HRR over the 12-week study period. Participants will also subjectively monitor workout intensity using the 20-point Borg's Rating of Perceived Exertion. participants will walk or jog pre-determined routes in trails of an urban forest (Pacific Spirit Park).
Group II: Aerobic Exercise IndoorsActive Control1 Intervention
Each session will consist of 10 min of warm-up, 40 min of aerobic exercise, and 10 min of cool-down. Aerobic exercise will be progressive and of moderate intensity. During training, each participant will wear a heart rate monitor and will be asked to work initially at approximately 45% of his/her target heart rate (i.e., heart rate reserve (HRR)) and gradually progress to reach the target of 70% of HRR over the 12-week study period. Participants will also subjectively monitor workout intensity using the 20-point Borg's Rating of Perceived Exertion. Participants will walk or jog on treadmills or cycle on stationary bikes in the Exercise Prescription Suite of the Centre for Hip Health and Mobility.
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Who is running the clinical trial?
University of British ColumbiaLead Sponsor
1,415 Previous Clinical Trials
2,466,944 Total Patients Enrolled
Teresa Liu-Ambrose, PhDPrincipal InvestigatorUniversity of British Columbia
4 Previous Clinical Trials
569 Total Patients Enrolled
Matthew Noseworthy, BScPrincipal InvestigatorUniversity of British Columbia
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have significant problems with your eyesight, hearing, or ability to move.You have a serious problem with your nerves, muscles, or joints.You need to score between 18 and 24 out of 30 on a test called the Montreal Cognitive Assessment to qualify.You have been regularly doing moderate to intense exercise in the past 3 months.You are currently planning to participate in another study or program that focuses on improving memory or thinking abilities.You recently had a head injury, like a concussion.You are currently undergoing therapy or treatment for cognitive improvement or using electromagnetic stimulation as prescribed by a healthcare professional.You have reported problems with your memory or thinking abilities during an interview.You have a serious neurological, brain blood vessel, or mental health condition, or another long-term medical condition that needs frequent and careful treatment.
Research Study Groups:
This trial has the following groups:- Group 1: Aerobic Exercise Outdoors
- Group 2: Aerobic Exercise Indoors
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Am I eligible to contribute to this research?
"For admittance into this medical trial, applicants must have been diagnosed with mild cognitive impairment and fall between the ages of 65 to 80. A total of 68 participants are being accepted for the study."
Answered by AI
What are the prime goals of this scientific experiment?
"This Baseline to 12 weeks trial has Change in List Sorting Performance as its primary goal. Secondary measurements include alterations of physical activity (measured via MotionWatch 8), sleep quality (assessed through the Pittsburgh Sleep Quality Index) and slumber patterns (again, observed by means of MotionWatch 8)."
Answered by AI
How many subjects are being examined in this clinical trial?
"Affirmative. According to records on clinicaltrials.gov, this medical trial is currently in the midst of recruiting participants, having been first posted on January 19th 2022 and recently updated November 5th 2022. 68 individuals are required for enrolment at a single site."
Answered by AI
Are there still vacancies available for those seeking to participate in this experiment?
"The data hosted on clinicaltrials.gov verifies that this experiment is actively recruiting participants, having been initially posted in January 19th 2021 and edited most recently on November 5th 2022."
Answered by AI
Is this research endeavor open to participants who are older than 20?
"This research necessitates that participants are aged 65-80. There is 25 trials available for minors and 746 specifically targeting seniors."
Answered by AI
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