PATH-MCI for Depression

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Depression+1 MorePATH-MCI - Behavioral
Eligibility
60 - 85
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare two therapies for people with mild cognitive impairment: Problem Adaptation Therapy (PATH) and Supportive Therapy (ST). The goal is to see which therapy improves cognitive, affective, and functional outcomes more.

Eligible Conditions
  • Cognitive Impairment
  • Depression

Treatment Effectiveness

Study Objectives

1 Primary · 4 Secondary · Reporting Duration: Baseline, 6, 12, 24, 36, and 52 Weeks

Week 52
Change in Episodic Memory assessed by subscale of RBANS
Change in Executive Function assessed by Trail Making Test
Change in Global Cognition assessed by RBANS
Week 52
Change in Depression assessed by MADRS
Change in Stress Reduction assessed by Perceived Stress Scale
Change in disability function assessed with WHODAS-II

Trial Safety

Trial Design

2 Treatment Groups

Supportive Therapy
1 of 2
PATH-MCI
1 of 2

Active Control

Experimental Treatment

80 Total Participants · 2 Treatment Groups

Primary Treatment: PATH-MCI · No Placebo Group · N/A

PATH-MCI
Behavioral
Experimental Group · 1 Intervention: PATH-MCI · Intervention Types: Behavioral
Supportive Therapy
Behavioral
ActiveComparator Group · 1 Intervention: Supportive Therapy · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 6, 12, 24, 36, and 52 weeks

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,414 Previous Clinical Trials
3,484,113 Total Patients Enrolled
28 Trials studying Depression
24,315 Patients Enrolled for Depression
Johns Hopkins UniversityOTHER
2,077 Previous Clinical Trials
31,020,158 Total Patients Enrolled
50 Trials studying Depression
27,569 Patients Enrolled for Depression
Montefiore Medical CenterOTHER
407 Previous Clinical Trials
553,223 Total Patients Enrolled
2 Trials studying Depression
241 Patients Enrolled for Depression
Weill Medical College of Cornell UniversityLead Sponsor
990 Previous Clinical Trials
1,339,289 Total Patients Enrolled
60 Trials studying Depression
15,752 Patients Enrolled for Depression
Dimitris Kiosses, PhDPrincipal InvestigatorWeill Medical College of Cornell University
6 Previous Clinical Trials
595 Total Patients Enrolled
4 Trials studying Depression
348 Patients Enrolled for Depression

Eligibility Criteria

Age 60 - 85 · All Participants · 5 Total Inclusion Criteria

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Who else is applying?

What state do they live in?
New York100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
Weill Cornell Medicine100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%