30 Participants Needed

Olfactory Training for Mild Cognitive Impairment

(OTMCI Trial)

JN
Overseen ByJeffrey N Motter, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: New York State Psychiatric Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline. Memory for new odors is particularly diminished in these individuals. Existing treatments for AD do not improve these symptoms. A targeted treatment for improving sense of smell, called 'Olfactory Training', has been used to improve sense of smell in people with various forms of smell loss, though it is not known whether it can improve smell abilities and thinking abilities in patients who are at high risk of developing Alzheimer's disease. The investigators will conduct a randomized clinical trial with patients who have mild cognitive impairment (MCI). This is an early phase of memory loss that is worse than normal aging and may precede Alzheimer's disease. Patients will be randomized to either olfactory memory training or visual memory training for 3 months, with a final follow-up visit at 6 months. This study will attempt to determine if olfactory training is a useful for improving smell abilities, thinking abilities, and everyday functioning by examining change in these outcomes over time.

Who Is on the Research Team?

JN

Jeffrey N Motter, PhD

Principal Investigator

Research Foundation for Mental Hygiene, Inc.

Are You a Good Fit for This Trial?

This trial is for individuals aged 55-89 with mild cognitive impairment (MCI), who have memory or other cognitive complaints and score below certain levels on a memory test. They must have an informant to provide updates on their functioning.

Inclusion Criteria

I have noticed problems with my memory or other thinking skills.
I have been diagnosed with mild cognitive impairment based on memory tests.
My thinking and memory test score is 17 or higher.
See 2 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo Olfactory Memory Training or Visual Memory Training for 3 months

12 weeks
48 training sessions at home

Follow-up

Participants are monitored for changes in cognitive, olfactory, and functional measures

3 months
Visits at baseline, 3 months, and 6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Olfactory Training
Trial Overview The study tests if 'Olfactory Training' can improve the sense of smell, thinking abilities, and daily function in MCI patients compared to 'Visual Memory Training'. Participants are randomly assigned to one of these two training methods for three months.
How Is the Trial Designed?
2Treatment groups
Active Control
Group I: Visual Memory TrainingActive Control1 Intervention
Group II: Olfactory Memory TrainingActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

New York State Psychiatric Institute

Lead Sponsor

Trials
481
Recruited
154,000+

Jeffrey Motter

Lead Sponsor

Trials
1
Recruited
30+

Alzheimer's Association

Collaborator

Trials
103
Recruited
44,300+
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