Exercise Training for Long-Term COVID-19 Effects

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Mayo Clinic

Disqualifiers: Obesity, Musculoskeletal conditions, Cardiac ischemia, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 1 Jurisdiction This treatment is already approved in other countries

Compensation: Varies

Number of Visits: Unknown

Duration: 8 weeks

27 Participants Needed

Trial Summary

What is the purpose of this trial?

This research study is being done to find out what the longer-term physiological consequences of COVID-19 are, and to determine if exercise therapy can help improve lung function, heart function and overall fitness, and reduce symptoms in people recovering from SARS-CoV-2.

Research Team

Bryan Taylor, PhD

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for adults aged 21-75 who have recovered from COVID-19, confirmed by RT-PCR test. Participants should not be clinically obese or have conditions limiting exercise. They must be free of heart issues during rest and exertion and able to consent in writing.

Inclusion Criteria

You have been declared as fully recovered from a SARS-CoV-2 infection.

You have had a confirmed SARS-CoV-2 infection detected by RT-PCR test in the past.

You are between 21 and 75 years old.

Exclusion Criteria

You are unable to participate in exercise training because of an injury or a condition that could make it risky for you to exercise.

You are younger than 21 or older than 75 years old.

Unable to provide written informed consent

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants complete exercise testing, lung function testing, and cardiac imaging

1 week

Treatment

Participants undergo 8 weeks of exercise training or continue standard medical care

8 weeks

Post-Treatment Assessment

Participants undergo detailed exercise testing, lung function testing, and cardiac imaging after the intervention

1 week

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Exercise Training

Trial Overview The study aims to assess the long-term effects of COVID-19 on physical health and whether exercise training can improve lung and heart function, fitness levels, and reduce lingering symptoms in those recovering from the virus.

Participant Groups

Group I: Interventional (exercise training) Group Experimental Treatment 1 Intervention

8 week home-based exercise training

Group II: Control Group Active Control 1 Intervention

Standard physician-guided medical care after COVID-19

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+