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Physical Activity for Cognitive Decline

N/A

Recruiting

Led By Neha P Gothe, MA, PhD

Research Sponsored by University of Illinois at Urbana-Champaign

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

TICS-M score of 32 or higher

Good or corrected vision and hearing

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 6 months, 12 months

Awards & highlights

Study Summary

This trial will compare the efficacy of yoga with aerobic exercise and stretching-toning exercises on cognitive function, brain structure and function, cardiorespiratory fitness, functional fitness, and inflammatory and molecular markers in adults ages 55-79.

Who is the study for?

This trial is for older adults aged 55-79 who are generally healthy, have good vision and hearing (with aids if needed), can move without assistance, and score above a threshold on a cognitive screening test. They should be low-active, right-handed, able to participate in fitness testing with their doctor's approval, and plan to stay in the Champaign-Urbana area during the study.Check my eligibility

What is being tested?

The study compares three types of exercise: yoga (Hatha), aerobic exercises, and stretching-toning activities. Participants will do these hour-long sessions three times weekly for six months. The goal is to see which activity best improves brain function and structure, physical fitness levels, as well as certain blood markers.See study design

What are the potential side effects?

Since this trial involves physical activity like yoga or aerobic exercises rather than medication or invasive procedures, side effects may include typical exercise-related issues such as muscle soreness or strain but no severe drug-like side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My thinking and memory test score is 32 or higher.

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My vision and hearing are good or corrected.

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I can walk on my own without help.

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I am between 55 and 79 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 6 months, 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 6 months, 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 months, 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in cognitive function

Secondary outcome measures

Change in brain function

Change in brain structure

Other outcome measures

Changes in cardiovascular fitness

Body Weight Changes

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Yoga GroupExperimental Treatment1 Intervention

Participants will be led through a beginner yoga course taught by a certified yoga instructor. Classes will meet three times a week for 60 minutes over the 6 month study duration. Sessions will focus on yoga postures, breathing, and meditative practices and may utilize mats, blocks, belts, and blankets.

Group II: Aerobic GroupExperimental Treatment1 Intervention

Trained exercise instructors will lead participants through an aerobic group exercise class. Sessions will begin with a 15-20 minute aerobics class and increase in duration over the 6 months capping off at 40-minutes per session. The prescribed intensity will be 50-60% of the maximum heart rate reserve for weeks one to six and 60-75% for the remainder of the program.

Group III: Stretching Toning GroupActive Control1 Intervention

Participants randomized to this group will meet three times a week for an hour-long structured group exercise session. This group will perform stretching and toning exercises using resistance bands, balance disks, and exercise mats.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Physical Activity

2019

Completed Phase 3

~4710

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Illinois at Urbana-ChampaignLead Sponsor

188 Previous Clinical Trials

37,167 Total Patients Enrolled

14 Trials studying Aging

1,687 Patients Enrolled for Aging

Wayne State UniversityOTHER

307 Previous Clinical Trials

108,315 Total Patients Enrolled

1 Trials studying Aging

186 Patients Enrolled for Aging

Neha P Gothe, MA, PhDPrincipal InvestigatorUniversity of Illinois at Urbana-Champaign

2 Previous Clinical Trials

117 Total Patients Enrolled

Media Library

Physical Activity Clinical Trial Eligibility Overview. Trial Name: NCT04323163 — N/A

Aging Clinical Trial 2023: Physical Activity Highlights & Side Effects. Trial Name: NCT04323163 — N/A

Aging Research Study Groups: Aerobic Group, Stretching Toning Group, Yoga Group

Physical Activity 2023 Treatment Timeline for Medical Study. Trial Name: NCT04323163 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who would be eligible to join this research project?

"This research study is currently accepting applications from right-handed individuals aged between 55 and 79. All potential recruits must have adequate hearing, vision, a TICS-M score of 32 or more, no history of mild cognitive impairment/dementia; and be low active exercisers (no more than two days per week). Furthermore, any health issues that may be exacerbated by physical activity should also be absent."

Answered by AI

Does this clinical trial permit participation from elderly individuals?

"This clinical trial has specified that the ideal patient demographic falls between 55 and 79 years of age. As a comparison, there are 25 studies for patients under 18 and 745 trials suitable for those above 65."

Answered by AI

Is enrollment for this experiment still ongoing?

"According to the information found on clinicaltrials.gov, this investigation is actively searching for volunteers as it was last modified on November 18th 2021 and posted initially on June 1st 2021."

Answered by AI

How many people are being enrolled in this medical research experiment?

"Affirmative. According to clinicaltrials.gov, this investigation is actively recruiting its participants. It was initially posted on June 1st 2021 and the most recent update took place on November 18th 2021 with a need for 168 subjects from one location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Yoga, Aerobic and Stretching Exercise Effects on Neurocognition

Neha P. Gothe 2021. "Yoga, Aerobic and Stretching Exercise Effects on Neurocognition". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04323163.