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Behavioral Intervention
Resistance Exercise for Cognitive Impairment
N/A
Waitlist Available
Led By Lindsay Nagamatsu, PhD
Research Sponsored by Western University, Canada
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10-15 minutes
Awards & highlights
Study Summary
This trial will test if resistance exercise can help improve cognition and brain structure in older adults at risk for type 2 diabetes.
Who is the study for?
This trial is for older adults aged 60-80 who are at risk for type 2 diabetes, meaning they're overweight or have higher than normal blood sugar levels. They should be generally healthy, with good vision (with glasses if needed), able to perform daily activities independently, and not currently doing regular exercise. They must speak English fluently and get a doctor's okay to start exercising.Check my eligibility
What is being tested?
The study is testing whether resistance exercise (like lifting weights) can help improve brain function and prevent cognitive decline in older adults who might develop diabetes. It builds on earlier research suggesting that this kind of physical activity could be beneficial for the brain.See study design
What are the potential side effects?
Resistance exercise is generally safe but can sometimes lead to muscle soreness, fatigue, or injury if not done correctly. The trial will likely monitor participants closely to minimize risks.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 10-15 minutes
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10-15 minutes
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Trail Making Test
Secondary outcome measures
Alzheimer's Disease Assessment Scale Cognitive Subscale 11
Nerve Growth Factors
Digit Span Test
+17 moreTrial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Resistance exerciseExperimental Treatment1 Intervention
Exercises will be completed in Kevin Shoemaker's (Co-I) exercise lab in the Health Sciences Building. Participants will use the programmable weight machines along with free weights to target the primary muscle groups. In addition, they will complete mini-squats, mini-lunges, and lunge walks. Participants will complete two sets of 6-8 reps. Training stimulus will be increased using the 7RM method - when 2 sets of 6-8 reps are completed with proper form and without discomfort. We will record the number of sets completed and the load lifted for each exercise for each participant at every class.
Group II: Control (balance and tone exercise)Active Control1 Intervention
Exercises will be completed in the Health Science Exercise lab. These will include stretching exercises, range of motion exercises, basic core-strength exercises, balance exercises, and relaxation techniques. Only bodyweight will be applied (i.e., no additional loading). This group controls for confounding variables such as physical training received by traveling to the training centres, social interaction, and changes in lifestyle secondary to study participation (Liu-Ambrose et al., 2010; Liu-Ambrose et al., 2012; Nagamatsu et al., 2012; Nagamatsu et al., 2013).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Resistance exercise
2000
Completed Phase 2
~1120
Find a Location
Who is running the clinical trial?
Western University, CanadaLead Sponsor
239 Previous Clinical Trials
57,423 Total Patients Enrolled
Lindsay Nagamatsu, PhDPrincipal InvestigatorWestern University
1 Previous Clinical Trials
216 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have been diagnosed with a neurodegenerative disease like dementia, Alzheimer's, or Parkinson's.I have untreated depression and a low score on a depression scale.I am currently using hormone replacement therapy.I cannot have blood drawn for medical reasons.I am between 60 and 80 years old and live in a community setting.You have a higher chance of developing diabetes because of one or more of the following: i) your blood glucose level is between 6.1-7 mmol/L, ii) your body mass index (BMI) is over 25, or iii) you scored more than 21 on the CANRISK diabetes questionnaire.I have severe nerve, muscle, or joint problems.I have been diagnosed with a mental health condition.I am currently taking medication for my mental health.You live independently in your own home or community.I am between 60 and 80 years old.
Research Study Groups:
This trial has the following groups:- Group 1: Control (balance and tone exercise)
- Group 2: Resistance exercise
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is eligibility for the clinical trial limited to those 18 years of age or older?
"This research requires that participants are aged between 60 and 80, in order to satisfy the inclusion criteria."
Answered by AI
Is a call for participants open in this research program?
"Clinicaltrials.gov confirms that this trial, which was posted on September 1st 2022 and updated most recently on 9th of the same month, is not presently looking for participants. However, there are 52 other medical studies currently recruiting patients at this time."
Answered by AI
Is it possible for me to participate in this clinical investigation?
"This trial is willing to accept 70 applicants who display cognitive alterations and fit within the acceptable age range of 60-80."
Answered by AI
Who else is applying?
What state do they live in?
Ontario
How old are they?
65+
What portion of applicants met pre-screening criteria?
Met criteria
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