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Nicotine

Cigarette Smoking for Cancer

N/A
Waitlist Available
Led By Theodore L Wagener, PhD
Research Sponsored by Ohio State University Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approx. 30 minutes
Awards & highlights

Study Summary

This trial is testing if different types of e-liquids have different effects on how much nicotine people get from smoking e-cigarettes, how much they like it, and how harmful it is.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approx. 30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and approx. 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Drug Effects Liking Questionnaire (DEQ)
Exhaled breath carbon monoxide (CO)
Minnesota Nicotine Withdrawal Scale
+7 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm I (pronated e-liquid, unprotonated e-liquidExperimental Treatment4 Interventions
VISIT 2: Patients receive 1 puff of tobacco flavored or unflavored protonated e-liquid and undergo 0-15 min head and 5 min chest PET?CT and then 0-15 min chest and 5 min head PET/CT. About 2 hours post initial PET/CT, patients receive a second puff of tobacco flavored or unflavored protonated e-liquid and undergo 0-15 min chest and 5 min head PET/CT and then 0-15 min head and 5 min chest PET/CT. VISIT 3: Patients receive 1 puff of tobacco flavored or unflavored unprotonated e-liquid and undergo 0-15 min head and 5 min chest PET/CT and then 0-15 min chest and 5 min head PET/CT. About 2 hours post initial PET/CT, patients receive a second puff of tobacco flavored or unflavored protonated e-liquid and undergo 0-15 min chest and 5 min head PET/CT and then 0-15 min head and 5 min chest
Group II: Arm II (unprotonated e-liquid, protonated e-liquidActive Control4 Interventions
VISIT 2: Patients receive 1 puff of tobacco flavored or unflavored unprotonated e-liquid and undergo 0-15 min head and 5 min chest PET/CT and then 0-15 min chest and 5 min head PET/CT. About 2 hours post initial PET/CT, patients receive a second puff of tobacco flavored or unflavored unprotonated e-liquid and undergo 0-15 min chest and 5 min head PET/CT and then 0-15 min head and 5 min chest. VISIT 3: Patients receive 1 puff of tobacco flavored or unflavored protonated e-liquid and undergo 0-15 min head and 5 min chest PET/CT and then 0-15 min chest and 5 min head PET/CT. About 2 hours post initial PET/CT, patients receive a second puff of tobacco flavored or unflavored protonated e-liquid and undergo 0-15 min chest and 5 min head PET/CT and then 0-15 min head and 5 min chest PET/CT.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cigarette Smoking
2022
N/A
~20
Computed Tomography
2017
Completed Phase 2
~2790
Positron Emission Tomography
2008
Completed Phase 2
~2260

Find a Location

Who is running the clinical trial?

Ohio State University Comprehensive Cancer CenterLead Sponsor
316 Previous Clinical Trials
289,666 Total Patients Enrolled
Theodore L Wagener, PhDPrincipal InvestigatorOhio State University Comprehensive Cancer Center
4 Previous Clinical Trials
2,057 Total Patients Enrolled

Media Library

Free-Base Nicotine (Nicotine) Clinical Trial Eligibility Overview. Trial Name: NCT05455086 — N/A
Cancer Research Study Groups: Arm I (pronated e-liquid, unprotonated e-liquid, Arm II (unprotonated e-liquid, protonated e-liquid
Cancer Clinical Trial 2023: Free-Base Nicotine Highlights & Side Effects. Trial Name: NCT05455086 — N/A
Free-Base Nicotine (Nicotine) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05455086 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being included in the research project?

"Affirmative, the clinical trial is still recruiting and this information can be found on clinicatrials.gov. This study has been active since March 23rd 2022 and was recently edited on July 8th 2022; 30 participants are needed from a single site of recruitment."

Answered by AI

Is it possible for me to enroll in this research project?

"This research study is seeking 30 volunteers with a cigarette smoking-related carcinoma, aged between 21 and 50. Participants must possess the aptitude to read and comprehend English, live within 20 miles of Wake Forest University if using study transport services, demonstrate exclusive eCigarette usage for 6 months (substantiated by NicAlert saliva testing strip), offer informed consent and abstain from tobacco or nicotine use in the 12 hours prior to visits two and three, acquiesce in 3 laboratory appointments."

Answered by AI

Is enrollment still open for this clinical experiment?

"Yes, this clinical trial is actively enrolling patients. The study was initiated on March 23rd 2022 and last edited July 8th 2022 according to the data supplied by clinicaltrials.gov"

Answered by AI

Does this clinical trial allow participants of any age?

"As specified in the study's eligibility requirements, patients must be between 21 and 50 years old to participate."

Answered by AI
~7 spots leftby Mar 2025