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Behavioral Intervention

Cognitive Bias Modification for Opioid Use Disorder (OABM Trial)

N/A

Recruiting

Led By David Pennington, PhD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Chronic pain (current pain lasting ≥ 90 days)

High risk for opioid-related adverse outcomes (≥ 20mg morphine equivalent daily dose)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to end of treatment, week 3

Awards & highlights

OABM Trial Summary

This trial is investigating whether a new treatment can reduce problematic opioid use by changing people's cognitive biases away from opioids.

Who is the study for?

This trial is for male and female veterans aged 18-69 who are eligible for VA services, have been prescribed opioids for chronic pain (lasting over 90 days) and are at high risk of opioid-related issues due to a daily dose equivalent to or exceeding 20mg of morphine. Pregnant women or those trying to conceive, individuals in other treatment studies, with severe opioid withdrawal symptoms, unstable psychiatric disorders, certain brain conditions or MRI contraindications cannot participate.Check my eligibility

What is being tested?

The study tests 'opioid approach bias modification' against sham training to see if it can alter the tendency towards prescription drug use by using ultra-high field MRI technology. The goal is to understand how the brain reacts during this process and potentially develop a new method to reduce harmful opioid use among veterans.See study design

What are the potential side effects?

Since this trial involves behavioral therapy and MRI scans rather than medication, traditional side effects like you might expect from drugs aren't applicable here. However, participants may experience discomfort from staying still during an MRI scan.

OABM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been experiencing pain for 90 days or more.

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I take a high dose of pain medication daily.

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I am between 18 and 69 years old.

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I have been on opioids for chronic pain for at least 90 days in the past year.

OABM Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to end of treatment, week 3

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to end of treatment, week 3

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to end of treatment, week 3 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in reaction time on an opioid approach-avoidance task across time, baseline to end of treatment, week 3

OABM Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: opioid approach bias trainingExperimental Treatment1 Intervention

Immediately following screening, patients will be randomly assigned to receive 6 sessions of opioid approach bias modification taking place over two weeks.

Group II: sham trainingPlacebo Group1 Intervention

Immediately following screening, patients will be randomly assigned to receive 6 sessions of sham training taking place over two weeks.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor

2,505 Previous Clinical Trials

15,237,535 Total Patients Enrolled

13 Trials studying Chronic Pain

1,781 Patients Enrolled for Chronic Pain

David Pennington, PhDPrincipal InvestigatorUniversity of California, San Francisco

1 Previous Clinical Trials

128 Total Patients Enrolled

Steven Batki, MDPrincipal InvestigatorUniversity of California, San Francisco

Media Library

Opioid Approach Bias Modification (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04436926 — N/A

Chronic Pain Research Study Groups: sham training, opioid approach bias training

Chronic Pain Clinical Trial 2023: Opioid Approach Bias Modification Highlights & Side Effects. Trial Name: NCT04436926 — N/A

Opioid Approach Bias Modification (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04436926 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research include any minors?

"Eligibility requirements for this particular trial state that patients must be aged 18 to 69. Out of the 45 clinical trials available for patients under 18, and the 464 clinical trials available to patients over the age of 65, this is the only one that they qualify for."

Answered by AI

Can people with the qualifying medical condition still join the trial?

"Correct. According to the information available on clinicaltrials.gov, this trial is currently open for enrolment. The trial was first posted on March 1, 2021 and was last updated on May 2, 2022. 20 participants are needed for the trial, which will be conducted at a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Opioid Approach Bias Modification

2021. "Opioid Approach Bias Modification". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04436926.

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