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CCTA first approach with Cardiac Link for Chest Pain (RESOLVE Trial)

N/A
Waitlist Available
Led By Elsie T Nguyen, MD, FRCPC
Research Sponsored by Elsie Nguyen
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, which may take up to 1 year
Awards & highlights

RESOLVE Trial Summary

This study will evaluate the ability of Coronary Computed Tomography Angiography (CCTA), used as a first-line diagnostic tool in women with stable chest pain and low risk for Coronary Artery Disease (CAD), to reduce the number of women requiring more than one diagnostic test to rule in or rule out CAD. Half of the participants will undergo CCTA as the first test to investigate stable chest pain, while the other half will undergo any test ordered by their family physician.

Eligible Conditions
  • Chest Pain

RESOLVE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, which may take up to 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, which may take up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total Number of Tests
Secondary outcome measures
Cumulative Radiation Dose Exposure (milliSieverts)
Hospital/ER visits
Number of Normal Invasive Diagnostic Angiograms
+3 more
Other outcome measures
Incidence of Cardiovascular Events
Incidence of Procedure Related Adverse Events

RESOLVE Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: CCTA first approach without Cardiac LinkExperimental Treatment1 Intervention
Patient will undergo Coronary Computed Tomography Angiography as the first test, but Cardiac Link pathway will not be activated.
Group II: CCTA first approach with Cardiac LinkExperimental Treatment2 Interventions
Patient will undergo Coronary Computed Tomography Angiography as the first test and have Cardiac Link pathway activated for expedited cardiology referral.
Group III: Usual Care without Cardiac LinkActive Control1 Intervention
Patient will undergo the usual diagnostic test ordered by their family physician as the first test, but Cardiac Link pathway will not be activated.
Group IV: Usual Care with Cardiac LinkActive Control2 Interventions
Patient will undergo the usual diagnostic test ordered by their family physician as the first test, and have Cardiac Link pathway activated for expedited cardiology referral.

Find a Location

Who is running the clinical trial?

Elsie NguyenLead Sponsor
Elsie T Nguyen, MD, FRCPCPrincipal InvestigatorWomen's College Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Risk Evaluation and Stratification of Low Risk for Cardiovascular Disease in Women
Elsie Nguyen 2019. "Risk Evaluation and Stratification of Low Risk for Cardiovascular Disease in Women". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03929341.
All > Cardiovascular
~21 spots leftby Apr 2025
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