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Different Exercise Intensities for Exercise Response in Muscle and Fat Tissue (3X Trial)

N/A
Waitlist Available
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age: 18-40
Women must have regularly occurring menses and must be premenopausal
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 minutes after exercise
Awards & highlights

3X Trial Summary

This trial will study how different intensities of exercise affect gene expression in skeletal muscle cells.

Who is the study for?
This trial is for healthy adults aged 18-40 with a BMI of 20-30 who regularly exercise at moderate to vigorous intensity. Women participants should have regular menstrual cycles and not be pregnant or breastfeeding. Smokers, those with recent weight fluctuations, cardiovascular or metabolic diseases, or on certain medications are excluded.Check my eligibility
What is being tested?
The study is examining how skeletal muscle and fat tissue respond to different exercise intensities: low, moderate, and high-intensity interval exercises. It aims to understand changes in gene expression and chromatin accessibility in these tissues after acute exercise sessions.See study design
What are the potential side effects?
Since the interventions involve physical exercise of varying intensities, potential side effects may include typical post-exercise symptoms such as muscle soreness, fatigue, shortness of breath during activity, and increased heart rate.

3X Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 40 years old.
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I am a woman who has regular periods and am not in menopause.

3X Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 minutes after exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 minutes after exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
mRNA expression of adipose tissue metabolic enzymes
mRNA expression of skeletal muscle oxidative enzymes
post-translational modifications of Adipose tissue metabolic proteins
+1 more

3X Trial Design

3Treatment groups
Experimental Treatment
Group I: moderate-intensity continuous exerciseExperimental Treatment1 Intervention
subjects will exercise at 65% maximal oxygen consumption (VO2max) for 30-45 minutes
Group II: low-intensity continuous exerciseExperimental Treatment1 Intervention
subjects will exercise at 30% maximal oxygen consumption (VO2max) for 45-60 minutes
Group III: high-intensity interval exerciseExperimental Treatment1 Intervention
subjects will completed 10x1minute exercise intervals at maximal oxygen consumption (VO2max) with 1 minute active recovery between

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,795 Previous Clinical Trials
6,373,891 Total Patients Enrolled

Media Library

High intensity exercise session Clinical Trial Eligibility Overview. Trial Name: NCT05365334 — N/A
Skeletal Muscle Adaptations to Exercise Research Study Groups: moderate-intensity continuous exercise, low-intensity continuous exercise, high-intensity interval exercise
Skeletal Muscle Adaptations to Exercise Clinical Trial 2023: High intensity exercise session Highlights & Side Effects. Trial Name: NCT05365334 — N/A
High intensity exercise session 2023 Treatment Timeline for Medical Study. Trial Name: NCT05365334 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for trial participants?

"As of the time of writing, this medical study is still recruiting. It was initially posted on December 13th 2021 and was last modified on May 6th 2022 according to clinicialtrials.gov."

Answered by AI

Would I be eligible to register for this investigation?

"For this study, 45 individuals aged 18-40 are requested who already present cellular responses in skeletal muscle due to varied levels of exercise. Furthermore, applicants must have a BMI ranging from 20-30 kg/m2 and regularly commit to aerobic activity for 30-60 minutes at least 3 times per week. Additionally, willing participants can opt into the Michigan Genomics Initiative Repository (MGI). Women need to confirm that their menstrual cycle is regular and premenopausal."

Answered by AI

What is the cohort size for this clinical trial?

"Indeed, clinicaltrials.gov data indicates that this medical study is actively looking for participants to enroll with the trial first posted on December 13th 2021 and most recently revised on May 6th 2022. At present, 45 patients are needed from a single facility."

Answered by AI

Does this investigation accept volunteers of a certain age or younger?

"This research initiative is seeking volunteers between the age of majority and 40 to participate in their trial."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities
Jeffrey F Horowitz 2021. "Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05365334.
~24 spots leftby Dec 2026
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