Your session is about to expire
← Back to Search
Antioxidant Cocktail for Stroke Prevention
N/A
Recruiting
Led By William G Schrage, PhD
Research Sponsored by University of Wisconsin, Madison
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age between ≥18 - ≤40 years
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 months
Awards & highlights
Study Summary
This trial will study the effects of ROS on CBF in 30 healthy adults aged 18-40, over two visits over 6 months.
Who is the study for?
Healthy adults aged 18-40 can join this study on reactive oxygen species and brain blood flow. Excluded are those with high blood pressure, glucose levels, or a history of heart, liver, kidney diseases; smokers; certain medication users; MRI contraindications; women with irregular menstrual cycles or using hormonal birth control (except copper IUDs).Check my eligibility
What is being tested?
The trial is testing an antioxidant cocktail against a placebo in 30 healthy participants to understand its effect on cerebral blood flow. The study spans over six months with two visits.See study design
What are the potential side effects?
Since the intervention includes antioxidants which are generally considered safe for most people when used appropriately, side effects might be minimal but could include potential allergic reactions or gastrointestinal discomfort.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 40 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cerebral Blood Flow: Hyperoxia
Cerebral Blood Flow: Normoxia
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Antioxidant CocktailExperimental Treatment1 Intervention
The first dose will be 500 mg vitamin C, 200 IU vitamin E, and 300 mg of alpha lipoic acid 120 minutes before MRI. The second dose will be 500 mg vitamin C, 400 IU vitamin E, and 300 mg of alpha lipoic acid 60 minutes before MRI.
Group II: PlaceboActive Control1 Intervention
Placebo 120 minutes before MRI, followed by another dose of placebo 60 minutes before MRI.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Antioxidant Cocktail
2011
Completed Phase 2
~290
Find a Location
Who is running the clinical trial?
University of Wisconsin, MadisonLead Sponsor
1,189 Previous Clinical Trials
3,169,501 Total Patients Enrolled
14 Trials studying Stroke
271,120 Patients Enrolled for Stroke
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,840 Previous Clinical Trials
47,852,094 Total Patients Enrolled
86 Trials studying Stroke
537,505 Patients Enrolled for Stroke
William G Schrage, PhDPrincipal InvestigatorUniversity of Wisconsin, Madison
2 Previous Clinical Trials
26 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You are sensitive to NSAIDs (non-steroidal anti-inflammatory drugs).I am taking medication for my heart condition.I have been diagnosed with sleep apnea.I have been diagnosed with diabetes.I have or had an autoimmune disease like lupus or inflammatory bowel disease.I have had a heart attack before.You are unable to have an MRI due to reasons like needing medication to stay calm during the scan.Women with irregular periods are not eligible.I am between 18 and 40 years old.I have been diagnosed with high blood pressure.You have smoked or used nicotine products more than 5 times in the last 30 days.I have or had liver disease.I have had heart surgery in the past or have been diagnosed with a condition requiring it.You have a body mass index (BMI) of 25 or higher.I am using a levonorgestrel IUD for birth control.I am a woman with excessive hair growth on my face, chest, or back.Your blood sugar level when you haven't eaten is higher than 100 milligrams per deciliter.I have or had peripheral vascular disease.I have a condition affecting my menstrual cycle.My blood pressure is higher than 125/80 mmHg.I have or had lung disease.I have or had stomach or intestinal problems that caused bleeding.I have had a stroke or currently have one.I have or had kidney disease.I have or had a blood disorder.Your LDL cholesterol is equal to or higher than 130 mg/dl.I have been diagnosed with or have a history of prediabetes.Your triglyceride levels are higher than 150 mg/dl.I have been diagnosed with polycystic ovary syndrome.I have or had coronary heart disease.I have been diagnosed with or have a history of heart failure.
Research Study Groups:
This trial has the following groups:- Group 1: Placebo
- Group 2: Antioxidant Cocktail
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is eligibility to participate in this experiment open?
"In order to be eligible for this research, applicants must have had a stroke and fall between the age of 18 and 40. The investigators are looking to enroll approximately 30 patients."
Answered by AI
Does the research involve participants aged 35 and over?
"The upper limit of the age requirement for eligibility is 40 years old, while a minimum age of 18 needs to be met."
Answered by AI
Is enrollment ongoing for this clinical trial?
"Presently, the clinical trial listed on clinicaltrials.gov is not seeking additional candidates. This research venture was initially announced August 1st of 2023 and has seen its last update on July 14th of the same year. While this particular study does not require applicants at present, there are 31 other trials actively recruiting patients."
Answered by AI
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger