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Aerobic training for Spinocerebellar Ataxias

N/A
Waitlist Available
Led By Scott Barbuto, MD PhD
Research Sponsored by Columbia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

Effect of Training on Brain Volume in Ataxia

Eligible Conditions
  • Spinocerebellar Ataxias

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cerebellar volume
Secondary outcome measures
Ataxia severity
Balance
Cognition
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic trainingExperimental Treatment1 Intervention
Participants will be given a stationary exercise bike for home use. They will be instructed to use the exercise bike five times a week for thirty-minute sessions. The exercise intensity prescription will be based on the subject's VO2max determined on pre-test day. The exercise program will start at 60% of intensity per session, and then will be increased by steps of 5% intensity every 2 sessions until participants reach 30 minutes of training at 80% intensity. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be instructed to log each training session. Subjects will record duration of exercise, perceived exertion, average heart rate, maximum heart rate, and distance.
Group II: Balance trainingActive Control1 Intervention
Balance Training A physical therapist will tailor a home balance training program for each participant based on pre- training capabilities. Subjects will be asked to perform exercises five times a week for thirty-minute sessions. Both dynamic and static exercises will be performed in sitting and standing positions. Exercises will start with stabilizing in a challenging static position and progress to dynamic arm and leg movements in the same or modified position. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be required to log their exercise effort in terms of frequency and level of balance challenge. Individuals will be instructed to perform more difficult exercises if balance
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic training
2016
Completed Phase 2
~1670

Find a Location

Who is running the clinical trial?

Columbia UniversityLead Sponsor
1,431 Previous Clinical Trials
2,460,795 Total Patients Enrolled
4 Trials studying Spinocerebellar Ataxias
316 Patients Enrolled for Spinocerebellar Ataxias
Scott Barbuto, MD PhDPrincipal InvestigatorColumbia University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effect of Training on Brain Volume in Ataxia
Scott Barbuto 2021. "Effect of Training on Brain Volume in Ataxia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04837027.
~10 spots leftby Apr 2025
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