Resistance Training for Hypertension

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Illinois at Chicago, Chicago, IL
Hypertension+2 More
Resistance Training - Other
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether aerobic exercise or resistance training may have positive impacts for individuals with multiple sclerosis.

See full description

Eligible Conditions

  • Hypertension
  • Cardiovascular Diseases
  • Vascular Diseases

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Resistance Training will improve 1 primary outcome and 2 secondary outcomes in patients with Hypertension. Measurement will happen over the course of Baseline (wk. 0), Pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24).

Baseline (wk. 0), Pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24)
Changes in arterial stiffness
Changes in endothelial function
Changes in peripheral and central blood pressure

Trial Safety

Trial Design

2 Treatment Groups

Aerobic Training
1 of 2
Resistance Training
1 of 2
Experimental Treatment

This trial requires 140 total participants across 2 different treatment groups

This trial involves 2 different treatments. Resistance Training is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Aerobic Training
Other
Participants will undergo a supervised endurance training program in accordance with established guidelines. Each session will be monitored by a physical therapist or exercise physiologist. Sessions will be carried out 3 times per week. During each session, participants will complete a 5 min warm-up followed by 30-45 min of endurance exercise using cycle ergometry. Intensity will be monitored using heart rate monitors during each exercise session, and each participant will receive an exercise prescription with a heart range equivalent to 65-85% of their heart rate max. Participants will be asked to complete 30 min of exercise during each session in week 1, 35 min in week 2 and 40-45 min weeks 3-8 with a 5 min cool down period.
Resistance Training
Other
Participants will undergo a supervised resistance training program in accordance with established guidelines. Each session will be monitored by a physical therapist or exercise physiologist. Sessions will be carried out 3 times per week, 45 min per session. Muscle strength will be determined once before and once after resistance training by measuring ten repetition maximum (10 RM) for each exercise. Eight exercises (three sets; 8-12 repetitions) will be used on each of the large muscle groups (leg press, leg extension, leg curl, chest press, shoulder extension, biceps curl, abdominal crunch and back extension). In addition, workloads will be progressively increased if the patients can lift the weight more than 12 repetitions.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline (wk. 0), pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline (wk. 0), pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24) for reporting.

Who is running the study

Principal Investigator
S. P.
Prof. Shane Phillips,, PhD
University of Illinois at Chicago

Closest Location

University of Illinois at Chicago - Chicago, IL

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Sedentary
A person with a BMI of 18.5-40 kg/m² is considered to be overweight. show original
Born in the United States of either two African-American or two non-Hispanic Caucasian parents
Blood pressure of at least 120/80 mmHg

Patient Q&A Section

What is hypertension?

"It is important for patients to understand that hypertension is a normal, normalising phenomenon in our society, which they can expect to keep in control if they take responsibility for their own prevention. Patients with hypertension may suffer a more gradual deterioration in their health than those who would not be suffering from hypertension. But it is not clear if hypertension patients have worse health outcome, compared to normotensive population." - Anonymous Online Contributor

Unverified Answer

How many people get hypertension a year in the United States?

"One in five persons (18%) meets the threshold of high blood pressure according to NCHD 2015 guidelines to be diagnosed with hypertension. Data from a recent study provides evidence for an increase in both prevalence and risk of hypertension across the lifespan among different demographic groups." - Anonymous Online Contributor

Unverified Answer

What are the signs of hypertension?

"Signs of hypertension are those that reflect sustained elevation of blood pressure over a period of weeks or longer. Many factors affect the amount and severity of signs experienced.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for hypertension?

"We found only a single (non-randomized) uncontrolled double-blind study comparing propranolol to propranolol plus captopril but did not find any well-controlled clinical studies. Given that the use of only three studies could only be justified based on the quality of the studies and methodological limitations within them, a more comprehensive evaluation is required." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving resistance training?

"There have been no previous trials on the role of a resistance exercise training programme in preventing cardiovascular events in patients with cardiovascular risk factors. However, the results of this study suggest that resistance exercise might be beneficial in preventing cardiovascular events through the improvement in left ventricular wall thinning and systolic function." - Anonymous Online Contributor

Unverified Answer

What is the latest research for hypertension?

"There is a lot of the latest research regarding hypertension in the last 10 years. There is very good research for antihypertensive agents. The study that is most recently published was about ACE inhibitor use, or angiotensin converting enzyme inhibitor use, in the treatment of hypertension in Asians. In the United States there is now good evidence that people treated with ACE inhibitor can have a greater improvement in their blood pressure. There is good evidence that people treated with calcium channel blockers, or calcium channel blockers, have a greater improvement in blood pressure." - Anonymous Online Contributor

Unverified Answer

Can hypertension be cured?

"Hypertension is a chronic disease that can lead to increased morbidity and mortality. Despite the fact that it cannot be prevented, it can be controlled through pharmacotherapy and lifestyle changes." - Anonymous Online Contributor

Unverified Answer

What causes hypertension?

"Numerous factors affect the occurrence of hypertension. These factors include both genetic and environmental factors, which may not all be explained by a single factor." - Anonymous Online Contributor

Unverified Answer

How serious can hypertension be?

"Hyper-tension can affect life expectancy even in middle aged individuals of moderate or less hypertensives. It has shown high mortality, coronary heart disease, heart attacks and stroke related morbidity. High SBP >160 and DBP 105-129 are not uncommon in the general population. It is important to avoid high blood pressure as it can prolong one's life expectancy." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of hypertension?

"We found that males were affected by hypertension more often than females ( p = 0.027), whereas there was a greater prevalence of males with a cardiovascular risk factor in this sample. Data from a recent study showed that the main determinant of hypertension is family history of the disease and is in accordance with the observation that males tended to have a higher rate of occurrence than females. Therefore, this should be taken into account in the study of blood pressure in future studies." - Anonymous Online Contributor

Unverified Answer

Is resistance training safe for people?

"Resistance training was well tolerated, with most of the participants gaining a sufficient number of lean tissues to reduce their body fat, whilst maintaining the same weight set-point. However, a number of subjects felt that their health improved with resistance training, and it is important that resistance training is well understood and accepted as a form of complementary treatment before starting." - Anonymous Online Contributor

Unverified Answer

Has resistance training proven to be more effective than a placebo?

"Resistance training over a four-week intervention was generally safe and effective, whereas a placebo had minimal impact on physical or psychological characteristics. Resistance training may be a useful intervention in the prevention of further cardiovascular damage associated with type 2 Diabetes, but clinical trials should be designed to address this important clinical issue as well as the long term benefits sustained by participants." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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