Web-Based Exercise Program for Obesity

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Overseen ByJacob Kariuki, PhD, NP
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Emory University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a web-based exercise program called the PATH intervention to help adults with obesity become more active. Participants will either use the PATH program or join an attention control group, which involves behavioral pain management strategies and later access to the program. The researchers aim to determine if this online approach can motivate people with obesity, who aren't meeting activity guidelines, to increase their physical activity. Ideal candidates for this trial have a BMI of 30 or higher, do not currently exercise for at least 150 minutes a week, and have regular internet access. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could lead to new ways to support healthier lifestyles.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research shows that the PATH program is safe for people with obesity. Studies have found that adults with overweight or obesity find the program easy to follow and acceptable. Participants in earlier trials did not report any major problems. The program encourages increased physical activity, which is generally safe for most adults. However, starting a new exercise routine can sometimes cause minor issues like sore muscles. Consulting a healthcare provider before beginning is always advisable. Overall, research suggests that the PATH program is well-tolerated and safe.12345

Why are researchers excited about this trial?

Researchers are excited about the PATH Intervention for obesity because it offers a web-based exercise program specifically tailored for individuals who are insufficiently active. Unlike traditional treatments like diet modifications, medication, or in-person fitness plans, PATH provides flexibility and accessibility through an online platform, making it easier for participants to integrate into their daily lives. This innovative approach empowers users to engage with the program on their own schedule, potentially increasing adherence and effectiveness. By combining digital convenience with personalized exercise guidance, PATH aims to tackle obesity in a way that fits seamlessly into modern lifestyles.

What evidence suggests that this trial's treatments could be effective for obesity?

Research has shown that online exercise programs, such as the PATH intervention included in this trial, can assist with weight management. One study found that these digital exercise programs help adults lose weight and reduce body fat. Another study demonstrated that online group programs significantly aid in weight loss. Additionally, people generally find these online programs easy to use and helpful. Overall, this suggests that the PATH intervention could be a promising method for helping individuals with obesity manage their weight. Participants in this trial may also join the Attention Control Group, which will receive access to the PATH program at the study's conclusion.678910

Who Is on the Research Team?

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Jacob Kariuki, PhD, NP

Principal Investigator

Emory University

Are You a Good Fit for This Trial?

This trial is for adults with obesity who are not very active, have a BMI of 30 or higher, and don't exercise much (less than 150 minutes of moderate activity per week). They must be able to use the internet regularly and track their physical activity. People can't join if they're pregnant, planning to get pregnant soon, have mobility issues, need supervised exercise due to certain conditions like stroke or heart disease unless cleared by a doctor.

Inclusion Criteria

Regular access to the Internet
Non-adherence to the PA Guidelines (<150 min of MVPA/wk)
BMI ≥30kg/m^2
See 1 more

Exclusion Criteria

Pregnancy or intention to become pregnant within 6 months
Individuals with history of heart disease, diabetes, or those who respond in affirmative to any question in the Physical Activity Readiness Questionnaire will be required to obtain Primary Care Provider (PCP) clearance before enrollment
I have a condition that limits my ability to move or requires supervised physical activity.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are assigned to either the PATH intervention or the attention control group for 6 months

24 weeks
Monthly virtual check-ins with a health coach

Follow-up

Participants are monitored for changes in physical activity and health metrics after the intervention

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Attention Control Intervention
  • Dietary education
  • PATH Intervention
  • Physical activity tracker
Trial Overview The study tests the PATH intervention—a web-based program designed to increase physical activity—against an attention control group that receives dietary education. Participants will also use a physical activity tracker to monitor their progress.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: PATH InterventionExperimental Treatment3 Interventions
Group II: Attention Control GroupActive Control3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Emory University

Lead Sponsor

Trials
1,735
Recruited
2,605,000+

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Trials
3,987
Recruited
47,860,000+

Citations

Effectiveness of a web-based real-life weight management ...Data on weight, diet, physical activity, and mood are collected online over the 12-month program. The participants are asked to provide their weight data at ...
Acceptability and Preliminary Efficacy of a Novel Web ...This study aimed to describe the protocol of a study that aims to examine the acceptability and preliminary efficacy of PATH intervention among ...
Guideline-Based Digital Exercise Interventions for Reducing ...This study aimed to evaluate the effectiveness of digital exercise interventions based on PA guidelines in reducing BW and fat in adults with ...
The effectiveness and usability of online, group-based ...A meta-analysis on four studies indicated that online, group-based interventions had a statistically significant impact on weight loss.
Effects of a Web-Based Lifestyle Intervention on Weight ...The web-based weight loss program was investigated both in an online questionnaire study [32] and regionally in southwest Germany with ...
Pathways: A school-based program for the primary prevention ...This report describes the proposed intervention and outcome measurement procedures for the Pathways study. Pathways is a multicenter school-based study ...
An overview of the “Positive Action for Today's Health ...The PATH trial is designed to examine a 24-month environmental intervention designed to improve safety and access for PA and trail use in three underserved ...
Feasibility and preliminary efficacy of a novel web-based ...The PATH intervention is feasible/acceptable and demonstrated preliminary efficacy for promoting PA among adults with overweight/obesity.
The range of outcomes and outcome measurement ...The most frequently collected outcomes from each of these domains included body mass index (89%), physical activity (73%), fruit and vegetable ...
10.researchprotocols.orgresearchprotocols.org/2025/1/e67972
Protocol for a Pilot Randomized Controlled TrialThe PATH intervention offers a promising, evidence-based approach to overcoming the barriers that have hindered previous PA programs for adults with obesity.
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