Treatment for Cardiovascular Diseases

Phase-Based Estimates
1
Effectiveness
1
Safety
Purdue University, West Lafayette, IN
Cardiovascular Diseases+2 More
Eligibility
18+
All Sexes
Eligible conditions
Cardiovascular Diseases

Study Summary

This study is evaluating whether a diet high in red meat and low in plant-based proteins may increase the risk of heart disease.

See full description

Eligible Conditions

  • Cardiovascular Diseases
  • Healthy Diet
  • Cardiovascular Risk

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 4 secondary outcomes in patients with Cardiovascular Diseases. Measurement will happen over the course of 5 weeks.

5 weeks
Change in consumer perception and satisfaction of the HEPs
Risk factors for cardiometabolic disease
Risk factors for cardiovascular disease
Week 15
Body weight

Trial Safety

Safety Estimate

1 of 3

Trial Design

3 Treatment Groups

Moderate RM, moderate NSS

This trial requires 60 total participants across 3 different treatment groups

This trial involves 3 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Moderate RM, moderate NSS
Other
Participants in this group will consume five 3-oz-eq servings of RM per week and 5-oz-eq servings of NSS per week.
Low RM, high NSS
Other
Participants in this group will consume one 3-oz-eq serving of RM per week and 8-oz-eq servings of NSS per week.
High RM, low NSS
Other
Participants in this group will consume nine 3-oz-eq servings of RM per week and 2-oz-eq servings of NSS per week.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: measures will be taken twice per week throughout the entire enrollment period (15 weeks)
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly measures will be taken twice per week throughout the entire enrollment period (15 weeks) for reporting.

Who is running the study

Principal Investigator
W. C.
Wayne Campbell, Principal Investigator
Purdue University

Closest Location

Purdue University - West Lafayette, IN

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
BMI: 25.0-37 kg/m2;
Have hypercholesterolemia (total and LDL cholesterol 200-259 and 130-189 mg/dL, respectively)
Systolic/diastolic blood pressure <140/90 mm Hg;
Triglycerides <399 mg/dL, fasting glucose <109 mg/dL
Body weight stable for 3 months prior (±3 kg);
Male or female;
Age 30-69 y;
Stable physical activity regimen 3 months prior;
Medication use stable for 6 months prior;
Non-smoking;

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is cardiovascular diseases?

Add answer

There is an increase in cardiovascular disease risk in both primary prevention (20%, 1.3 million U.S.-based adults) and secondary prevention (15% post-diagnosis, 5.5 million U.S.-based adults). While prevalence of premature death among men was lowest among Black men (8.1 per 1000), it is highest among Black women (52.3 per 1000). Women overall show a 6 times higher risk for premature death than men. These women have a disproportionately higher incidence of coronary heart disease, myocardial infarctions, and stroke.

Unverified Answer

What are the signs of cardiovascular diseases?

Add answer

Signs of cardiovascular disease include excessive drinking, high blood pressure, high cholesterol, increased resting heart rate, high blood fat levels, diabetes, heart attacks, and strokes. These conditions all require medical consultation.

Unverified Answer

What causes cardiovascular diseases?

Add answer

Coronary risk factors are important determinants of CVD but they are not causes or risk factors themselves. Other risk factors including diabetes, high blood pressure, lipid abnormalities, smoking and obesity are important modifiers of the effect of cholesterol on coronary risk. Physical activity protects against CVD events. Physical activity is highly effective at reducing the risk of diabetes and cardiovascular disease.

Unverified Answer

What are common treatments for cardiovascular diseases?

Add answer

The most common treatments for cardiovascular diseases are aspirin, beta blockers, and statins. For coronary heart disease patients, a low dose aspirin regimen is recommended. Statins are the most common medication for treating high blood cholesterol levels, but are rarely used to treat cardiovascular disease. In patients with peripheral arterial disease, cholesterol-lowering drug treatment is helpful.

Unverified Answer

Can cardiovascular diseases be cured?

Add answer

CVD is largely preventable if it is detected early. The risk of developing CVD and death can be reduced by a healthy lifestyle and regular screening for disease. Patients with CVD, especially who are hypertensives, should be assessed for risk of heart failure; those patients are more likely to develop heart failure than those without CVD.

Unverified Answer

How many people get cardiovascular diseases a year in the United States?

Add answer

Around 100,000 people in the United States die each year from cardiovascular disease. This represents 23.1% of all US deaths. The most common cause of death from cardiovascular diseases are coronary heart disease and cerebrovascular disease.

Unverified Answer

What is treatment?

Add answer

The [Heart Protection Initiative (HPI) trial (http://www.hpi.org.au) will assess whether patients with cardiovascular risk factors can receive some benefit from a medication regimen containing aspirin plus either clopidogrel or ticlopidine. A total of 25,000 patients will be recruited for the study over a period of five years.

Unverified Answer

How serious can cardiovascular diseases be?

Add answer

Heart attacks are [just as serious as cancer or diabetes<nowiki>]</nowiki> [heart disease is more important than all other diseases combined] (http://www.heart.org/). If you have high blood pressure, take pills to reduce your risk of dying. If you have a heart attack, see your doctor as soon as you can and tell them about any symptoms you may have. If you are older, take your pills at least two hours earlier than usual. People younger than 70 years old should also [take their pills at least two hours sooner than usual]. Follow your doctor's advice when you are thinking of having a child. Taking a shower [and avoiding water baths (i.e.

Unverified Answer

How does treatment work?

Add answer

The most common problem with clinical management of patients with HSCR was not recognizing the condition and not taking medication. In the future, new treatment concepts and approaches may focus on specific risk factors, such as early diagnosis and treatment with angiotensin converting enzyme (ACE) inhibitors to minimize arterial wall damage in patients with a history of hypertension.

Unverified Answer

Does cardiovascular diseases run in families?

Add answer

These data confirm the significance of familial factors in the development of CVD and provide important insights to justify early detection of CVD in the family members.

Unverified Answer

What is the average age someone gets cardiovascular diseases?

Add answer

Based on survey results, there are 2 main conclusions. \n1. For cardiovascular diseases, women are more likely to get it.\n2. For diabetes mellitus, the age for onset happens later for men, and the prevalence stays higher as the age increases.\n\nMany studies exist about risk factors of chronic diseases such as arthritis or [lung cancer](https://www.withpower.com/clinical-trials/lung-cancer). However, there are still little evidences of which gender can influence health risks more than others. Epidemiological data show that both male and female are equally affected by chronic diseases. However, female are more likely to get more types of cancers at younger ages (e.g. breast cancer, colorectal cancer, liver cancer).

Unverified Answer

Who should consider clinical trials for cardiovascular diseases?

Add answer

There is a significant underresearcher bias found in cardiovascular clinical trials, which is similar to previously reported data in pharmacology. Underresearchers were significantly more likely to encounter financial problems when they pursued these trials, and were also less likely to receive financial support from pharmaceutical companies.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Cardiovascular Diseases by sharing your contact details with the study coordinator.