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Radiation Therapy

Adaptive Radiation Therapy for Liver Cancer

N/A

Waitlist Available

Led By Theodore Lawrence, M.D., Ph.D.

Research Sponsored by University of Michigan Rogel Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 months

Awards & highlights

Study Summary

This trial is testing a new way to do radiation therapy for liver cancer that is customized to each patient. The goal is to improve safety and efficacy. If this new approach is promising, the investigators will proceed to a phase II randomized study.

Eligible Conditions

Liver Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Median Time to Local Progression

Percentage of Patients With Change in Child Pugh Score >= 2

The Proportion of Patients for Whom the Intended Treatment Was Feasible

Secondary outcome measures

Change in ALBI Scores

Incidence of Grade 3 Gastrointestinal (GI) Bleeding Toxicities

Median Time to Progression

+1 more

Other outcome measures

Incidence of Radiation Induced Liver Disease (RILD)

Trial Design

1Treatment groups

Experimental Treatment

Group I: Adaptive Radiation TherapyExperimental Treatment1 Intervention

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Adaptive Radiation Therapy

2016

N/A

~80

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Michigan Rogel Cancer CenterLead Sponsor

293 Previous Clinical Trials

24,020 Total Patients Enrolled

4 Trials studying Liver Cancer

866 Patients Enrolled for Liver Cancer

National Institutes of Health (NIH)NIH

2,693 Previous Clinical Trials

6,951,515 Total Patients Enrolled

6 Trials studying Liver Cancer

1,936 Patients Enrolled for Liver Cancer

Theodore Lawrence, M.D., Ph.D.Principal InvestigatorRogel Cancer Center

1 Previous Clinical Trials

34 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there currently any open enrollment opportunities for this research project?

"According to data available on clinicaltrials.gov, this medical trial is not currently searching for new participants. Originally posted on 26 January 2016 and last updated 11 May 2022, the study has since concluded but 2609 other studies are now actively enrolling."

Answered by AI

What hopes are investigators pursuing with this experiment?

"The primary endpoint of this trial, which will be evaluated during a period starting at baseline and ending 6 months after the commencement of SBRT treatment, is whether or not the proposed intervention was feasible in terms of patient numbers. Secondary benchmarks include median time to progression (duration from start of treatment until observed growth), change in ALBI scores (liver decompensation assessed by 0.5+ shift from initial measurement) and overall survival rate (amount of time between beginning therapy and death)."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Pilot Study of Individualized Adaptive Radiation Therapy for Hepatocellular Carcinoma

2016. "A Pilot Study of Individualized Adaptive Radiation Therapy for Hepatocellular Carcinoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02460835.