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CT Perfusion Scans for Liver Cancer

N/A

Recruiting

Led By Steven Y Huang, MD

Research Sponsored by M.D. Anderson Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline up to 6 weeks post pve

Awards & highlights

Study Summary

This trial uses CT scans to measure blood flow to the liver after portal vein embolization in patients with liver cancer. This may help predict the rate and amount of growth of new, healthy tissue on one side of the liver after the procedure.

Who is the study for?

This trial is for patients who need a major liver surgery for cancer and require Portal Vein Embolization (PVE) to increase healthy liver tissue before the operation. Participants must understand and agree to join the study. It's not suitable for pregnant or nursing individuals, those allergic to iodinated contrast without safe pre-medication, or with severe kidney issues.Check my eligibility

What is being tested?

The trial is examining how well CT perfusion scans can detect changes in blood flow in the liver after PVE. These scans use a standard contrast agent injected into veins to measure this flow, which may help predict new tissue growth and tumor size changes post-PVE.See study design

What are the potential side effects?

Potential side effects include reactions to the contrast agent used during CT perfusion imaging such as nausea, vomiting, warmth or pain at injection site, itching or rash. Kidney function might also be affected especially in those with pre-existing conditions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline up to 6 weeks post pve

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline up to 6 weeks post pve

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 6 weeks post pve for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Perfusion changes to the liver following portal vein embolization (PVE)

Secondary outcome measures

Changes to tumor cellular proliferation following PVE

Trial Design

1Treatment groups

Experimental Treatment

Group I: Diagnostic (CT perfusion scans, liver biopsy)Experimental Treatment2 Interventions

Prior to PVE, patients undergo CT perfusion scan of the liver and liver biopsy over 15 minutes. Patients undergo a second CT perfusion scan immediately after PVE and a third CT perfusion scan 3-6 weeks post PVE.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Computed Tomography Perfusion Imaging

2016

Completed Phase 2

~90

Liver Biopsy

2015

N/A

~270

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor

2,973 Previous Clinical Trials

1,789,299 Total Patients Enrolled

22 Trials studying Liver Cancer

9,411 Patients Enrolled for Liver Cancer

National Cancer Institute (NCI)NIH

13,664 Previous Clinical Trials

40,925,984 Total Patients Enrolled

104 Trials studying Liver Cancer

26,668 Patients Enrolled for Liver Cancer

Steven Y Huang, MDPrincipal InvestigatorM.D. Anderson Cancer Center

Media Library

Liver Cancer Research Study Groups: Diagnostic (CT perfusion scans, liver biopsy)

Liver Biopsy 2023 Treatment Timeline for Medical Study. Trial Name: NCT03990623 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people are involved in the research endeavor?

"Affirmative, the clinicaltrials.gov website shows that this experiment is currently looking for volunteers. This trial was initially posted on July 21st 2018 and underwent its most recent update around September 28th 2022. 22 study participants are required at 1 research centre."

Answered by AI

Is there a possibility to enroll in this clinical research at present?

"Yes, the information provided on clinicaltrials.gov alludes to this medical study being actively recruiting participants since July 21st 2018 and was recently updated on September 28th 2022. The research is aiming for a total of 22 volunteers at one single location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization

2018. "CT Perfusion Scans in Detecting Changes in Blood Flow to the Liver After Portal Vein Embolization". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03990623.